Robert Middlewick
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Differential remodeling in small and large murine airways revealed by novel whole lung airway analysis Open
Airway remodeling occurs in chronic asthma leading to increased airway smooth muscle (ASM) mass and extracellular matrix (ECM) deposition. Although extensively studied in murine airways, studies report only selected larger airways at one t…
Differential remodelling in small and large murine airways revealed by novel whole lung airway analysis Open
Airway remodelling occurs in chronic asthma leading to increased airway smooth muscle (ASM) mass and extra-cellular matrix (ECM) deposition. Whilst extensively studied in murine airways; studies report only selected larger airways at one t…
Investigating a role for heterotrimeric G-proteins in activating TGFβ in asthma Open
Asthma is a chronic inflammatory disease of the airways, affecting 5.4 million people in the UK. Asthma pathology is characterised by airway hyper-responsiveness, bronchoconstriction, and airway remodelling. Airway remodelling is particula…
View article: LOXL2 Mediates Airway Smooth Muscle Cell Matrix Stiffness and Drives Asthmatic Airway Remodelling
LOXL2 Mediates Airway Smooth Muscle Cell Matrix Stiffness and Drives Asthmatic Airway Remodelling Open
Airway smooth muscle cells (ASM) are fundamental to asthma pathogenesis, influencing bronchoconstriction, airway hyper-responsiveness, and airway remodelling. Extracellular matrix (ECM) can influence tissue remodelling pathways, however, t…