Robert Morrison
YOU?
Author Swipe
View article: Identification of Plasmodium falciparum VAR2CSA peptides differentially recognized by IgG of multigravidae through epitope excision
Identification of Plasmodium falciparum VAR2CSA peptides differentially recognized by IgG of multigravidae through epitope excision Open
Background Placental malaria is associated with adverse outcomes for both mothers and their newborn children. During pregnancy, Plasmodium falciparum –infected erythrocytes (IEs) that surface-express VAR2CSA can bind chondroitin sulfate (C…
View article: Transcript-Capture sequencing enriches mRNA of <i>Mycobacterium tuberculosis</i> from host samples
Transcript-Capture sequencing enriches mRNA of <i>Mycobacterium tuberculosis</i> from host samples Open
Bacterial gene expression from sites of infection are poorly studied due to low levels of bacterial mRNA present in clinical samples. Here, we develop Transcript-Capture Seq, which uses customizable biotinylated probes generated in-house t…
View article: SARS-CoV-2 Receptor Binding Domain (RBD) Protein–Protein Conjugate Induces Similar or Better Antibody Responses as Spike mRNA in Rhesus Macaques
SARS-CoV-2 Receptor Binding Domain (RBD) Protein–Protein Conjugate Induces Similar or Better Antibody Responses as Spike mRNA in Rhesus Macaques Open
Background/Objectives: Rapid development of vaccines against SARS-CoV-2 was pivotal to controlling the COVID-19 pandemic. The emergency also provided a rare opportunity to test novel vaccine platforms such as mRNA in large clinical trials.…
View article: High Prevalence of Pfdhps and Pfdhfr Resistance Markers to Sulfadoxine-pyrimethamine During Subpatent Parasitemia in Doneguebougou, Mali
High Prevalence of Pfdhps and Pfdhfr Resistance Markers to Sulfadoxine-pyrimethamine During Subpatent Parasitemia in Doneguebougou, Mali Open
View article: A novel locus in CSMD1 gene is associated with increased susceptibility to severe malaria in Malian children
A novel locus in CSMD1 gene is associated with increased susceptibility to severe malaria in Malian children Open
Background Plasmodium falciparum malaria is still a leading cause of child mortality in sub-Saharan Africa. The clinical manifestations of malaria range from asymptomatic infection to severe disease. The variation in clinical presentation …
View article: Sanger sequencing and deconvolution of polyclonal infections: a quantitative approach to monitor drug-resistant Plasmodium falciparum
Sanger sequencing and deconvolution of polyclonal infections: a quantitative approach to monitor drug-resistant Plasmodium falciparum Open
View article: Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine
Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine Open
Placental accumulation of Plasmodium falciparum infected erythrocytes results in maternal anemia, low birth weight, and pregnancy loss. The parasite protein VAR2CSA facilitates the accumulation of infected erythrocytes in the placenta thro…
View article: MtrA modulates Mycobacterium tuberculosis cell division in host microenvironments to mediate intrinsic resistance and drug tolerance
MtrA modulates Mycobacterium tuberculosis cell division in host microenvironments to mediate intrinsic resistance and drug tolerance Open
View article: Malaria transmission-blocking vaccines Pfs230D1-EPA and Pfs25-EPA in Alhydrogel in healthy Malian adults; a phase 1, randomised, controlled trial
Malaria transmission-blocking vaccines Pfs230D1-EPA and Pfs25-EPA in Alhydrogel in healthy Malian adults; a phase 1, randomised, controlled trial Open
View article: Preclinical evaluations of Pfs25-EPA and Pfs230D1-EPA in AS01 for a vaccine to reduce malaria transmission
Preclinical evaluations of Pfs25-EPA and Pfs230D1-EPA in AS01 for a vaccine to reduce malaria transmission Open
Malaria transmission-blocking vaccine candidates Pfs25-EPA and Pfs230D1-EPA target sexual stage development of Plasmodium falciparum parasites in the mosquito host, thereby reducing mosquito infectivity. When formulated on Alhydroge…
View article: Quantification of False Vocal Fold Hyperfunction During Quiet Breathing in Muscle Tension Dysphonia
Quantification of False Vocal Fold Hyperfunction During Quiet Breathing in Muscle Tension Dysphonia Open
Background/Objectives False vocal fold (FVF) hyperfunction during phonation is thought to be a diagnostic sign of primary muscle tension dysphonia (pMTD). However, hyperfunctional patterns with phonation are also observed in typical speake…
View article: <i>Mycobacterium tuberculosis</i> Gene Expression Associated With Fluoroquinolone Resistance and Efflux Pump Inhibition
<i>Mycobacterium tuberculosis</i> Gene Expression Associated With Fluoroquinolone Resistance and Efflux Pump Inhibition Open
Background We evaluated the relationship between response to efflux pump inhibition in fluoroquinolone-resistant Mycobacterium tuberculosis (Mtb) isolates and differences in gene expression and expression quantitative trait loci (eQTL). Me…
View article: Pregnancy outcomes in a malaria-exposed Malian cohort of women of child-bearing age
Pregnancy outcomes in a malaria-exposed Malian cohort of women of child-bearing age Open
In Sub-Saharan Africa, malaria continues to be associated with adverse pregnancy outcomes including stillbirth, early neonatal death, preterm delivery, and low birth weight. Current preventive measures are insufficient and new intervention…
View article: 605 Neoadjuvant vidutolimod (vidu) and nivolumab (nivo) results in MPR and immune activation in high-risk resectable melanoma (MEL): final phase II clinical trial results
605 Neoadjuvant vidutolimod (vidu) and nivolumab (nivo) results in MPR and immune activation in high-risk resectable melanoma (MEL): final phase II clinical trial results Open
Background Neoadjuvant PD-1 blockade produces major pathological responses (MPR) in ~30% of patients (pts) with high-risk resectable MEL with durable relapse-free benefit, and increased circulating activated CD8+ T cells.1,2 Vid…
View article: RNA editing in Mycobacterium tuberculosis
RNA editing in Mycobacterium tuberculosis Open
View article: Author Correction: Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity
Author Correction: Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity Open
View article: Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains
Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains Open
View article: Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity
Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity Open
View article: IFN-λ4 is associated with increased risk and earlier occurrence of several common infections in African children
IFN-λ4 is associated with increased risk and earlier occurrence of several common infections in African children Open
Genetic polymorphisms within the IFNL3 / IFNL4 genomic region, which encodes type III interferons, have been strongly associated with clearance of hepatitis C virus. We hypothesized that type III interferons might be important for the immu…
View article: MtrA regulation of essential peptidoglycan cleavage in<i>Mycobacterium tuberculosis</i>during infection
MtrA regulation of essential peptidoglycan cleavage in<i>Mycobacterium tuberculosis</i>during infection Open
The success of Mycobacterium tuberculosis (Mtb) is largely due to its ability to withstand multiple stresses encountered in the host. Here, we present a data-driven model that captures the dynamic interplay of environmental cues and genome…
View article: Transcriptional regulator-induced phenotype screen reveals drug potentiators in Mycobacterium tuberculosis
Transcriptional regulator-induced phenotype screen reveals drug potentiators in Mycobacterium tuberculosis Open
View article: Antimalarial antibody repertoire defined by plasma IG proteomics and single B cell IG sequencing
Antimalarial antibody repertoire defined by plasma IG proteomics and single B cell IG sequencing Open
Plasma antimalarial Ab can mediate antiparasite immunity but has not previously been characterized at the molecular level. Here, we develop an innovative strategy to characterize humoral responses by integrating profiles of plasma immunogl…
View article: Forensic Techniques for Establishing the Origin and Timing of a Contaminant Release
Forensic Techniques for Establishing the Origin and Timing of a Contaminant Release Open
View article: ODELAM, rapid sequence-independent detection of drug resistance in isolates of Mycobacterium tuberculosis
ODELAM, rapid sequence-independent detection of drug resistance in isolates of Mycobacterium tuberculosis Open
Antimicrobial-resistant Mycobacterium tuberculosis (Mtb) causes over 200,000 deaths each year. Current assays of antimicrobial resistance need knowledge of mutations that confer drug resistance, or long periods of culture time to test grow…
View article: Author response: ODELAM, rapid sequence-independent detection of drug resistance in isolates of Mycobacterium tuberculosis
Author response: ODELAM, rapid sequence-independent detection of drug resistance in isolates of Mycobacterium tuberculosis Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Antimicrobial-resistant Mycobacterium tube…
View article: ODELAM: Rapid sequence-independent detection of drug resistance in clinical isolates of Mycobacterium tuberculosis
ODELAM: Rapid sequence-independent detection of drug resistance in clinical isolates of Mycobacterium tuberculosis Open
Antimicrobial-resistant Mycobacterium tuberculosis (Mtb) causes over 200,000 deaths each year. Current assays of antimicrobial resistance need knowledge of mutations that confer drug resistance, or long periods of culture time to test grow…
View article: Daily Incentive and Jump-base in a Non-Real-Time Apparel Manufacturing Context
Daily Incentive and Jump-base in a Non-Real-Time Apparel Manufacturing Context Open
This study summarizes piecework incentive systems and examines two apparel manufacturing factories that used daily incentive calculations at one time and weekly incentive calculations at another. In addition, one factory implemented a mult…
View article: IFN-λ4 is associated with increased risk and earlier occurrence of gastrointestinal, respiratory and malarial infections in Malian children
IFN-λ4 is associated with increased risk and earlier occurrence of gastrointestinal, respiratory and malarial infections in Malian children Open
Genetic polymorphisms within the IFNL3 / IFNL4 genomic region, which encodes type III interferons, have been strongly associated with impaired clearance of hepatitis C virus (HCV) infection. We hypothesized that type III interferons might …
View article: US COMMUNITY BANK PROFITABILITY: A CROSS- SECTIONAL AND DYNAMIC PANEL ANALYSIS OF RURAL AND METROPOLITAN BANKS
US COMMUNITY BANK PROFITABILITY: A CROSS- SECTIONAL AND DYNAMIC PANEL ANALYSIS OF RURAL AND METROPOLITAN BANKS Open
This study compares 5,286 community banks operating in rural and metropolitan counties from 2000 through the end of 2013 on the variables contributing to bank profitability using pooled OLS, pooled time-series OLS, and dynamic panels metho…
View article: Analysis of Common Infections in Malian Children Under Five: IFNL4-dG Allele Is Associated with Higher Risk and Earlier Episodes of Gastrointestinal Infections
Analysis of Common Infections in Malian Children Under Five: IFNL4-dG Allele Is Associated with Higher Risk and Earlier Episodes of Gastrointestinal Infections Open