Robert N. Correll
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View article: Oral supplementation of fucoxanthin regulates gene expression in the brain of middle-aged rats
Oral supplementation of fucoxanthin regulates gene expression in the brain of middle-aged rats Open
Age is the main risk factor for many neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and frontotemporal dementia. Despite our limited understanding of cellular mechanisms of ageing-associated neuronal loss, an i…
View article: ATF6β is not essential for the development of physiological cardiac hypertrophy
ATF6β is not essential for the development of physiological cardiac hypertrophy Open
Physiological cardiac hypertrophy is a compensatory remodeling of the heart in response to stimuli such as exercise training or pregnancy that is reversible and well-tolerated. We previously described how the activating transcription facto…
View article: Transcriptomic analysis of coxsackievirus B3 infection in induced pluripotent stem cell-derived brain-like endothelial cells
Transcriptomic analysis of coxsackievirus B3 infection in induced pluripotent stem cell-derived brain-like endothelial cells Open
Viral aseptic meningitis is a neuroinflammatory condition that occurs when viruses gain access to the central nervous system (CNS) and induce inflammation. The blood–brain barrier (BBB) is comprised of brain endothelial cells (BECs) that s…
View article: Maternal Nitrate Supplementation As Adjuvant Therapy During a Hypertensive Pregnancy on Body Composition and Oxidative Stress
Maternal Nitrate Supplementation As Adjuvant Therapy During a Hypertensive Pregnancy on Body Composition and Oxidative Stress Open
Objectives: Hypertension during pregnancy leads to excessive oxidative stress (OS), risk for fetal growth restriction, and altered body composition throughout life partially due to inadequate placental perfusion resulting from OS. Dietary …
View article: Dietary Nitrate as an Adjuvant Therapy for Hypertensive Pregnancies and a Nutritional Modifier of Cardiovascular Programming in Offspring
Dietary Nitrate as an Adjuvant Therapy for Hypertensive Pregnancies and a Nutritional Modifier of Cardiovascular Programming in Offspring Open
Objectives: Hypertension during pregnancy is the leading cause of pregnancy-related mortality in the United States leading to long-term cardiovascular perturbations for both offspring and mothers. Although dietary nitrate is known to decre…
View article: Regulation of cardiac fibroblast cell death by unfolded protein response signaling
Regulation of cardiac fibroblast cell death by unfolded protein response signaling Open
The endoplasmic reticulum (ER) is a tightly regulated organelle that requires specific environmental properties to efficiently carry out its function as a major site of protein synthesis and folding. Embedded in the ER membrane, ER stress …
View article: Assessing wound closure in mice using skin-punch biopsy
Assessing wound closure in mice using skin-punch biopsy Open
Defects in myofibroblast function may cause wound healing defects in a variety of tissue types. Here we describe a simple skin-punch biopsy approach to screen mouse models for defects in wound closure that does not require extensive surgic…
View article: CIB1 is a regulator of pathological cardiac hypertrophy
CIB1 is a regulator of pathological cardiac hypertrophy Open
Hypertrophic heart disease is a leading health problem facing the Western world. Here we identified the small EF-hand domain-containing protein CIB1 (Ca2+ and integrin binding protein 1) in a screen for novel regulators of cardiomyocyte hy…
View article: Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart
Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart Open
Collagen production in the adult heart is thought to be regulated by the fibroblast, although cardiomyocytes and endothelial cells also express multiple collagen mRNAs. Molecular chaperones are required for procollagen biosynthesis, includ…
View article: Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis
Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis Open
Valosin-containing protein (VCP), also known as p97, is an ATPase with diverse cellular functions, although the most highly characterized is targeting of misfolded or aggregated proteins to degradation pathways, including the endoplasmic r…
View article: Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis
Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis Open
The master cytokine TGF-β mediates tissue fibrosis associated with inflammation and tissue injury. TGF-β induces fibroblast activation and differentiation into myofibroblasts that secrete extracellular matrix proteins. Canonical TGF-β sign…
View article: Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart
Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart Open
Our results indicate that LTCCs in the caveolae microdomain do not affect cardiac function and are not necessary for the regulation of hypertrophic signaling in the adult mouse heart.