Robert Nickl
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View article: P01.08.B CAPTURING FUNCTIONAL INTRATUMORAL HETEROGENEITY IN GLIOBLASTOMA: MAPPING REGIONAL METHYLOME AND TEMOZOLOMIDE RESPONSE USING PATIENT-DERIVED ORGANOIDS
P01.08.B CAPTURING FUNCTIONAL INTRATUMORAL HETEROGENEITY IN GLIOBLASTOMA: MAPPING REGIONAL METHYLOME AND TEMOZOLOMIDE RESPONSE USING PATIENT-DERIVED ORGANOIDS Open
BACKGROUND Glioblastoma (GBM) is the most common malignant primary brain tumor in adults and characterized by marked inter- and intratumoral heterogeneity, contributing to poor therapeutic response and high recurrence rates. In this study,…
View article: P01.07.A ESTABLISHING A SCREENING PLATFORM ON PATIENT-DERIVED ORGANOIDS TO IDENTIFY EFFECTIVE AGENTS TO TREAT GLIOBLASTOMA
P01.07.A ESTABLISHING A SCREENING PLATFORM ON PATIENT-DERIVED ORGANOIDS TO IDENTIFY EFFECTIVE AGENTS TO TREAT GLIOBLASTOMA Open
BACKGROUND Despite aggressive treatments, encompassing surgery, radiotherapy, and chemotherapy, glioblastoma (GBM) presents with poor prognosis and regular recurrence. To improve outcome for recurrent GBM, we established a translational pi…
View article: P02.05.B MAPPING MICROGLIAL DIVERSITY AND TUMOR HETEROGENEITY IN PRIMARY GLIOBLASTOMA AND PATIENT-DERIVED ORGANOIDS
P02.05.B MAPPING MICROGLIAL DIVERSITY AND TUMOR HETEROGENEITY IN PRIMARY GLIOBLASTOMA AND PATIENT-DERIVED ORGANOIDS Open
BACKGROUND Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, marked by extensive inter- and intratumoral heterogeneity and pronounced therapy resistance. Microglia is a major contributor to this complexity…
View article: P18.10.B INTER- AND INTRATUMORAL DRUG RESPONSE HETEROGENEITY IN GLIOBLASTOMA: A COMPARATIVE ORGANOID-BASED ANALYSIS OF TEMOZOLOMIDE AND VORTIOXETINE
P18.10.B INTER- AND INTRATUMORAL DRUG RESPONSE HETEROGENEITY IN GLIOBLASTOMA: A COMPARATIVE ORGANOID-BASED ANALYSIS OF TEMOZOLOMIDE AND VORTIOXETINE Open
BACKGROUND Inter- and intratumoral heterogeneity represents a major obstacle to the effective treatment of glioblastoma (GBM), contributing to therapy resistance and tumor recurrence. Vortioxetine, a multimodal antidepressant, has recently…
View article: Probabilistic mapping of gait changes after STN-DBS for Parkinson's disease
Probabilistic mapping of gait changes after STN-DBS for Parkinson's disease Open
Probabilistic mapping showed a strong correlation with therapy outcomes, especially gait improvement, and provided predictive value at the individual level. While the concept of sweet- or sourspots was insufficient to explain individual va…
View article: Quantifying physical degradation alongside recording and stimulation performance of 980 intracortical microelectrodes chronically implanted in three humans for 956-2246 days
Quantifying physical degradation alongside recording and stimulation performance of 980 intracortical microelectrodes chronically implanted in three humans for 956-2246 days Open
Motivation The clinical success of brain-machine interfaces depends on overcoming both biological and material challenges to ensure a long-term stable connection for neural recording and stimulation. Therefore, there is a need to quantify …
View article: Analysis of tumor microenvironment composition in vestibular schwannomas: insights into NF2-associated and sporadic variations and their clinical correlations
Analysis of tumor microenvironment composition in vestibular schwannomas: insights into NF2-associated and sporadic variations and their clinical correlations Open
Objective Vestibular schwannomas (VS), benign tumors stemming from the eighth cranial nerve’s Schwann cells, are associated with Merlin gene mutations, inflammation, and the tumor microenvironment (TME), influencing tumor initiation, maint…
View article: Characterization and Optimization of the Tumor Microenvironment in Patient-Derived Organotypic Slices and Organoid Models of Glioblastoma
Characterization and Optimization of the Tumor Microenvironment in Patient-Derived Organotypic Slices and Organoid Models of Glioblastoma Open
While glioblastoma (GBM) is still challenging to treat, novel immunotherapeutic approaches have shown promising effects in preclinical settings. However, their clinical breakthrough is hampered by complex interactions of GBM with the tumor…
View article: Probabilistic mapping of gait changes after STN-DBS for Parkinson’s disease
Probabilistic mapping of gait changes after STN-DBS for Parkinson’s disease Open
Objective. Gait disturbances causing impaired mobility are common in Parkinson’s disease after bilateral deep brain stimulation of the subthalamic nucleus. We describe subthalamic subregions where neurostimulation had a positive effect on …
View article: Malignant transformation of a cerebral dermoid cyst into a squamous cell carcinoma with malignant intraperitoneal spreading along a ventriculoperitoneal shunt: illustrative case
Malignant transformation of a cerebral dermoid cyst into a squamous cell carcinoma with malignant intraperitoneal spreading along a ventriculoperitoneal shunt: illustrative case Open
BACKGROUND Malignant progression of intracranial dermoid cysts into squamous cell carcinoma is extremely rare with only three reports published so far. Intracranial dermoid cysts are uncommon benign tumors lined by stratified squamous epit…
View article: War-related traumatic brain injuries during the Syrian armed conflict in Damascus 2014-2017: a cohort study and a literature review
War-related traumatic brain injuries during the Syrian armed conflict in Damascus 2014-2017: a cohort study and a literature review Open
Background: The decade-long Syrian armed conflict killed or injured more than 11% of the Syrian population. Head and neck injuries are the most frequent cause of war-related trauma, about half of which are brain injuries. Reports about Syr…
View article: Optimal deep brain stimulation sites and networks for cervical vs. generalized dystonia
Optimal deep brain stimulation sites and networks for cervical vs. generalized dystonia Open
Significance We studied deep brain stimulation effects in two types of dystonia and conclude that different specific connections between the pallidum and thalamus are responsible for optimal treatment effects. Since alternative treatment o…
View article: Differential Deep Brain Stimulation Sites and Networks for Cervical vs. Generalized Dystonia
Differential Deep Brain Stimulation Sites and Networks for Cervical vs. Generalized Dystonia Open
Dystonia is a debilitating disease with few conservative treatment options but many types of isolated dystonia can be effectively treated using deep brain stimulation (DBS) to the internal pallidum. While cervical and generalized forms of …
View article: Combined Frameless Stereotactical Biopsy and Intraoperative Cerebral Angiography by 3D-Rotational Fluoroscopy with Intravenous Contrast Administration. A Feasibility Study.
Combined Frameless Stereotactical Biopsy and Intraoperative Cerebral Angiography by 3D-Rotational Fluoroscopy with Intravenous Contrast Administration. A Feasibility Study. Open
Purpose: Mobile 3-dimensional fluoroscopes are available in a number of neurosurgical departments and can be used in combination with simple image post processing to depict cerebral vessels. In preparation of stereotactic surgery, preopera…
View article: Directional Leads for Deep Brain Stimulation: Technical Notes and Experiences
Directional Leads for Deep Brain Stimulation: Technical Notes and Experiences Open
Objective: Deep brain stimulation (DBS) is an approved treatment for movement disorders. Despite high precision in electrode placement, side effects do occur by current spread to adjacent fibers or nuclei. Directional leads (D-leads) are d…
View article: Probabilistic mapping of the antidystonic effect of pallidal neurostimulation: a multicentre imaging study
Probabilistic mapping of the antidystonic effect of pallidal neurostimulation: a multicentre imaging study Open
Deep brain stimulation of the internal globus pallidus is a highly effective and established therapy for primary generalized and cervical dystonia, but therapeutic success is compromised by a non-responder rate of up to 25%, even in carefu…
View article: Facial Nerve Function in a Series of 494 Vestibular Schwannomas: Improvement by Technological Amendments?
Facial Nerve Function in a Series of 494 Vestibular Schwannomas: Improvement by Technological Amendments? Open
Background and Objective As a consequence of conservative strategies such as watchful waiting or radiosurgical management, surgeons are faced mainly with medium to large vestibular schwannomas. Preservation of facial nerve function still r…
View article: Contrast-Enhanced CISS MRI Improves Visualization and Planning in Vestibular Schwannomas
Contrast-Enhanced CISS MRI Improves Visualization and Planning in Vestibular Schwannomas Open
Background Preoperative visualization is essential in planning of vestibular schwannoma operations. Still, there is often a considerable discrepancy between measured tumor size in MRI and intraoperative findings, especially regarding the i…
View article: Facial Nerve Elongation in Vestibular Schwannomas: A Useful Aspect with Regard to Functional Preservation
Facial Nerve Elongation in Vestibular Schwannomas: A Useful Aspect with Regard to Functional Preservation Open
Background The facial nerve is mostly displaced and stretched in an anterior direction in vestibular schwannomas. Preoperative visualization may be partially achieved by Gadolinium-enhanced CISS MRI (Gd-Ciss). The individual tumor shape an…
View article: Connectivity Predicts deep brain stimulation outcome in <scp>P</scp>arkinson disease
Connectivity Predicts deep brain stimulation outcome in <span>P</span>arkinson disease Open
Objective The benefit of deep brain stimulation (DBS) for Parkinson disease (PD) may depend on connectivity between the stimulation site and other brain regions, but which regions and whether connectivity can predict outcome in patients re…
View article: Short pulse width widens the therapeutic window of subthalamic neurostimulation
Short pulse width widens the therapeutic window of subthalamic neurostimulation Open
We explored the impact of pulse durations <60 μsec on the therapeutic window of subthalamic neurostimulation in Parkinson's disease. Current thresholds for full rigidity control and first muscle contractions were evaluated at pulse duratio…