Explanipedia

Synthesis of carbon dots from spent coffee grounds: transforming waste into potential biomedical tools Open

Yingru Zhou, Adalberto Camisasca, Sofia Dominguez‐Gil, Michał Bartkowski, Keith D. Rochfort , et al. · 2025

Carbon dots were synthesised from spent coffee grounds via a novel acetone precipitation approach, featuring superior physico-chemical properties for potential biomedical applications. Created in BioRender. Zhou, Y. (2025) https://BioRende…

Covalent Modification of p53 by (E)-1-(4-Methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one Open

Katie M. Brown, Marco Robello, Andrew J. Perciaccante, Jerry C. Dinan, Tapan K. Maity , et al. · 2024

TP53 is commonly mutated in cancer, giving rise to loss of wild-type tumor suppressor function and increases in gain-of-function oncogenic roles. Thus, inhibition of mutant p53 and reactivation of wild-type function represents a pot…

Evidence-based recommendations for gene-specific ACMG/AMP variant classification from the ClinGen ENIGMA BRCA1 and BRCA2 Variant Curation Expert Panel Open

Michael T. Parsons, Miguel de la Hoya, Marcy E. Richardson, Emma Tudini, Michael G. Anderson , et al. · 2024

The ENIGMA research consortium develops and applies methods to determine clinical significance of variants in hereditary breast and ovarian cancer genes. An ENIGMA BRCA1/2 classification sub-group, formed in 2015 as a ClinGen external expe…

IMPROVER (Involving Men with Prostate Cancer in Engaged Research): Assessing Patient Experience With Testing, Diagnosis, And Surveillance Open

M. C. Walsh, Asia Jordan, Lea Schäfer, Jana Joha, Ben Heapes , et al. · 2024

Greater public awareness and education around prostate cancer, as well as clear and accessible written information for patients at the beginning of their cancer journey is needed. Further research is needed into alternative, less invasive …

Challenges and approaches to calibrating patient phenotype as evidence for cancer gene variant classification under ACMG/AMP guidelines Open

Cristina Fortuño, Kyriaki Michailidou, Michael T. Parsons, Jill S. Dolinsky, Tina Pesaran , et al. · 2024

Since first publication of the American College of Medical Genetics and Genomics/Association for Medical Pathology (ACMG/AMP) variant classification guidelines, additional recommendations for application of certain criteria have been relea…

Evidence-based recommendations for gene-specific ACMG/AMP variant classification from the ClinGen ENIGMA BRCA1 and BRCA2 Variant Curation Expert Panel Open

Michael T. Parsons, Miguel de la Hoya, Marcy E. Richardson, Emma Tudini, Michael G. Anderson , et al. · 2024

The ENIGMA research consortium ( https://enigmaconsortium.org/ ) develops and applies methods to determine clinical significance of variants in Hereditary Breast and Ovarian Cancer genes. An ENIGMA BRCA1/2 classification sub-group, origina…

Impact of the COVID-19 pandemic on cancer care in Ireland – Perspectives from a COVID-19 and Cancer Working Group Open

Séamus O’Reilly, Hailey Carroll, Deirdre M. Murray, Louise Burke, Triona McCarthy , et al. · 2023

Alteration in Levels of Specific miRNAs and Their Potential Protein Targets between Human Pancreatic Cancer Samples, Adjacent Normal Tissue, and Xenografts Derived from These Tumors Open

Fiona O’Neill, Taylor-Jade Allen-Coyle, Sandra Roche, Justine Meiller, Neil T. Conlon , et al. · 2023

Herein, we describe the global comparison of miRNAs in human pancreatic cancer tumors, adjacent normal tissue, and matched patient-derived xenograft models using microarray screening. RNA was extracted from seven tumor, five adjacent norma…

Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and Their Prodrugs Open

Jung‐Eun Park, Hobin Lee, Paola Oliva, Klara Kirsch, Bo-Ra Kim , et al. · 2023

Polo-like kinase 1 (Plk1), a mitotic kinase whose activity is widely upregulated in various human cancers, is considered an attractive target for anticancer drug discovery. Aside from the kinase domain, the C-terminal noncatalytic polo-box…

P076: The ClinGen ENIGMA BRCA1/2 expert panel: A dynamic framework for evidence-based recommendations to improve classification criteria for variants in BRCA1/2* Open

Michael Parsons, Michael C. Anderson, Windy Berkofsky‐Fessler, Sandrine M. Caputo, Raymond C. K. Chan , et al. · 2023

Prioritising Informed Health Choices Key Concepts for those impacted by cancer: a protocol Open

Mengqi Li, Declan Devane, Claire Beecher, Austin G. Duffy, Caitríona Duggan , et al. · 2022

Background: Few areas of health have been as insidiously influenced by misinformation as cancer. Thus, interventions that can help people impacted by cancer reduce the extent to which they are victims of misinformation are necessary. The I…

Prioritising Informed Health Choices Key Concepts for those impacted by cancer: a protocol_Appendix Open

Mengqi Li, Declan Devane, Claire Beecher, Austin G. Duffy, Caitríona Duggan , et al. · 2022

We are developing an online education programme called Informed Health Choices-Cancer (IHC-C) based on the Informed Health Choices (IHC) initiative Key Concepts. We will provide those impacted by cancer with the knowledge and skills necess…

1002 Calcium administration in Major haemorrhage Protocol Open

Aemal Akhtar, Robert O’Connor, Jules Rosen, Anne Brooks · 2021

Introduction Calcium gluconate is an essential part of the major haemorrhage protocol (MHP). It minimizes the exacerbation of transfusion coagulopathies due to the citrate preservative. As fifty percent of trauma patients present with hypo…

Establishing a taxonomy of potential hazards associated with communicating medical science in the age of disinformation Open

David Robert Grimes, Laura Brennan, Robert O’Connor · 2020

Objectives Disinformation on medical matters has become an increasing public health concern. Public engagement by scientists, clinicians and patient advocates can contribute towards public understanding of medicine. However, depth of feeli…

P383 Exploring the need for enhanced mental health services in a paediatric cystic fibrosis clinic Open

Susan Hunt, Andrea Kench, Sharon Simonds, Camilla Boyton, Anna Middleton , et al. · 2020

P299 Use of the Polar™ H10 Heart Rate Sensor during the Modified Shuttle Walk Test in children with cystic fibrosis: can we demonstrate maximal response? Open

Robert O’Connor, Emma Raywood, Helen Douglas, Eleanor Main, C.S. Pao · 2020

Establishment and Characterisation by Expression Microarray of Patient-Derived Xenograft Panel of Human Pancreatic Adenocarcinoma Patients Open

Sandra Roche, Fiona O’Neill, Jean Murphy, Niall Swan, Justine Meiller , et al. · 2020

Pancreatic cancer remains among the most lethal cancers worldwide, with poor early detection rates and poor survival rates. Patient-derived xenograft (PDX) models have increasingly been used in preclinical and clinical research of solid ca…

Dasatinib Treatment Increases Sensitivity to c-Met Inhibition in Triple-Negative Breast Cancer Cells Open

Patricia Gaule, Nupur Mukherjee, B. Corkery, Alex J. Eustace, Kathy Gately , et al. · 2019

In pre-clinical studies, triple-negative breast cancer (TNBC) cells have demonstrated sensitivity to the multi-targeted kinase inhibitor dasatinib; however, clinical trials with single-agent dasatinib showed limited efficacy in unselected …

Issue Information Open

Editor-In-Chief Sanneke, Daniel P. Aldrich, Christopher Ansell, Erik Bækkeskov, Thomas A. Birkland , et al. · 2018

P138 Sampling methods used in non-expectorating children ≤3 years of age with cystic fibrosis in a London CF centre Open

Jacqueline Miller, Robert O’Connor, C.S. Pao · 2018

Issue Information Open

Editor-In-Chief Sanneke, Daniel P. Aldrich, Christopher Ansell, Erik Bækkeskov, Thomas A. Birkland , et al. · 2018

Bariatric Surgery–Induced Cardiac and Lipidomic Changes in Obesity‐Related Heart Failure with Preserved Ejection Fraction Open

Deana Mikhalkova, Sujata R. Holman, Hui Jiang, Sultan Ayesh Mohammed Saghir, Eric Novak , et al. · 2017

Objective To determine the effects of gastric bypass on myocardial lipid deposition and function and the plasma lipidome in women with obesity and heart failure with preserved ejection fraction (HFpEF). Methods A primary cohort ( N = 12) w…

Issue Information Open

Editor-In-Chief Sanneke, Daniel P. Aldrich, Christopher Ansell, Erik Bækkeskov, Thomas A. Birkland , et al. · 2017

Identification of potential new treatment response markers and therapeutic targets using a Gaussian process-based method in lapatinib insensitive breast cancer models Open

Tapesh Santra, Sandra Roche, Neil T. Conlon, Norma O’Donovan, John Crown , et al. · 2017

Molecularly targeted therapeutics hold promise of revolutionizing treatments of advanced malignancies. However, a large number of patients do not respond to these treatments. Here, we take a systems biology approach to understand the molec…

A non-contrast CMR index for assessing myocardial fibrosis Open

Qian Yin, Dana R. Abendschein, David Muccigrosso, Robert O’Connor, Thomas Goldstein , et al. · 2017

Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles Open

Vanessa Lopes-Rodrigues, Alessio Di Luca, Justyna Mleczko, Paula Meleady, Michael Henry , et al. · 2017

Issue Information Open

Scott T. Robinson, Daniel P. Aldrich, Thomas A. Birkland, Arjen Boin, Warren S. Eller , et al. · 2016

Structure-Based Screening of Uncharted Chemical Space for Atypical Adenosine Receptor Agonists Open

David Rodríguez, Saibal Chakraborty, Eugene Warnick, Steven Crane, Zhan‐Guo Gao , et al. · 2016

Small molecule screening libraries cover only a small fraction of the astronomical number of possible drug-like compounds, limiting the success of ligand discovery efforts. Computational screening of virtual libraries representing unexplor…

ePS02.6 Improving efficiency in an outpatient setting – Experience from a paediatric CF centre in East London Open

Amand F. Schmidt, Nanna Christiansen, Laplante Alice, Robert O’Connor, Catherine Lambert , et al. · 2016

Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3Adenosine Receptor Agonists Open

Dilip K. Tosh, Antonella Ciancetta, Eugene Warnick, Robert O’Connor, Zhoumou Chen , et al. · 2016

Purine (N)-methanocarba-5'-N-alkyluronamidoriboside A3 adenosine receptor (A3AR) agonists lacking an exocyclic amine resulted from an unexpected reaction during a Sonogashira coupling and subsequent aminolysis. Because the initial C6-Me an…

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