Robert Ortmann
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View article: Influence of the beam power on the density of pure copper samples in PBF-EB/M using a spot melting strategy
Influence of the beam power on the density of pure copper samples in PBF-EB/M using a spot melting strategy Open
Pure copper is well-suited for the powder bed fusion of metals using an electron beam. The main reason is that the high reflectivity of the copper powder is non-critical for the energy coupling of the electron beam compared to the laser be…
View article: Powder bed fusion of pure copper using an electron beam: a comparative study on the material properties obtained using vector- and spot-based exposure
Powder bed fusion of pure copper using an electron beam: a comparative study on the material properties obtained using vector- and spot-based exposure Open
Additive manufacturing of pure copper is of interest due to the materials thermal and electrical conductivity, corrosion resistance and ductility, as well as the possibility of creating value through the production of complex structures. P…
View article: Powder bed fusion of pure copper using an electron beam – achieving high conductivity by real-time process monitoring and control
Powder bed fusion of pure copper using an electron beam – achieving high conductivity by real-time process monitoring and control Open
Powder bed fusion of metals using an electron beam (PBF-EB/M) has reached market maturity. While most parts manufactured with PBF-EB/M are titanium-based, the rising interest in highly conductive pure copper is attracting attention from bo…
View article: Immunomodulatory effects of Simvastatin in Toll-like receptor-2 stimulated Rheumatoid arthritis synoviocytes
Immunomodulatory effects of Simvastatin in Toll-like receptor-2 stimulated Rheumatoid arthritis synoviocytes Open
Fibroblast-like synoviocytes (FLS) are major effector cells in Rheumatoid arthritis (RA). Toll-like receptor-2 (TLR2) activation of FLS plays a key role in RA pathogenesis. Recently, statins have been shown to modulate RA. We investigated …
View article: Powder bed fusion of AlSi10Mg using an electron beam: Processability, microstructure and mechanical properties
Powder bed fusion of AlSi10Mg using an electron beam: Processability, microstructure and mechanical properties Open
Powder bed fusion additive manufacturing processes of metals using an electron beam (PBF-EB/M) and laser beam (PBF-LB/M) are methods for producing complex near-net-shape parts layer upon layer, which are standardized in DIN EN ISO/ASTM 529…
View article: Immunomodulatory effects of Simvastatin in Toll-like receptor-2 stimulated Rheumatoid arthritis synoviocytes
Immunomodulatory effects of Simvastatin in Toll-like receptor-2 stimulated Rheumatoid arthritis synoviocytes Open
Fibroblast-like synoviocytes (FLS) are major effector cells in Rheumatoid arthritis (RA). Toll-like receptor-2 (TLR2) activation of FLS plays a key role in RA pathogenesis. Recently, statins have been shown to modulate RA. We investigated …
View article: Real-world burden of systemic lupus erythematosus in the USA: a comparative cohort study from the Medical Expenditure Panel Survey (MEPS) 2016–2018
Real-world burden of systemic lupus erythematosus in the USA: a comparative cohort study from the Medical Expenditure Panel Survey (MEPS) 2016–2018 Open
Objective SLE is a chronic, multiorgan, autoimmune disease; however, current prevalence estimates are dated and often from non-generalisable patient populations, and quality of life and patient-reported outcomes in the real-world SLE popul…
View article: Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations
Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations Open
Different JAKis modulated distinct cytokine pathways to varying degrees, and no agent potently or continuously inhibited an individual cytokine signaling pathway throughout the dosing interval. Notably, baricitinib inhibited JAK1/3 signali…
View article: Low rates of radiographic progression of structural joint damage over 2 years of baricitinib treatment in patients with rheumatoid arthritis
Low rates of radiographic progression of structural joint damage over 2 years of baricitinib treatment in patients with rheumatoid arthritis Open
Objectives To evaluate radiographic progression of structural joint damage over 2 years in patients with rheumatoid arthritis from baricitinib clinical trials who were disease-modifying antirheumatic drug (DMARD)–naïve or had an inadequate…
View article: Clinical outcomes in patients switched from adalimumab to baricitinib due to non-response and/or study design: phase III data in patients with rheumatoid arthritis
Clinical outcomes in patients switched from adalimumab to baricitinib due to non-response and/or study design: phase III data in patients with rheumatoid arthritis Open
NCT01710358, NCT01885078.
View article: Efficacy and safety of tabalumab, an anti-BAFF monoclonal antibody, in patients with moderate-to-severe rheumatoid arthritis and inadequate response to TNF inhibitors: results of a randomised, double-blind, placebo-controlled, phase 3 study
Efficacy and safety of tabalumab, an anti-BAFF monoclonal antibody, in patients with moderate-to-severe rheumatoid arthritis and inadequate response to TNF inhibitors: results of a randomised, double-blind, placebo-controlled, phase 3 study Open
Background Tabalumab is a human monoclonal antibody that neutralises B-cell activating factor. Objectives To evaluate tabalumab efficacy and safety in patients with rheumatoid arthritis (RA). Methods This phase 3, randomised, double-blind,…