Explanipedia

Notch signaling is a driver of glandular stem cell activity and regenerative migration after damage Open

Davide Cinat, Rufina Maturi, Jeremy P Gunawan, Anne L. Jellema-de Bruin, Laura Kracht , et al. · 2025

Organoid models have significantly enhanced our understanding of adult stem cell function, however, uncovering regulatory mechanisms governing rare and often quiescent stem cells in glandular organs remains challenging. Here, we employ an …

Role of Klhl14 in senescence and epithelial-to-mesenchymal transition via TGF-[beta] modulation Open

Rufina Maturi, Abel Soto-Gamez, Anne L. Jellema-de Bruin, Matteo Esposito, Schelto Kruijff , et al. · 2025

KLHL14, a component of an E3-ubiquitin ligase complex, has emerged as a context-dependent oncogene or tumor suppressor, particularly important for thyroid development. Yet its role in thyroid biology remains largely unexplored. In this stu…

Patient-derived medullary thyroid cancer organoids: a potential model for mechanistic studies on diagnostics and therapy Open

Eline C. Jager, Luc Sondorp, Rufina Maturi, Inês F. Antunes, Bettien M. van Hemel , et al. · 2025

Objective Medullary thyroid carcinoma (MTC) is a rare neuroendocrine thyroid tumor, with only 30 new patients annually in the Netherlands. PET imaging provides information on distant metastases, after which tyrosine kinase inhibitors (TKIs…

Selection of patients for proton therapy to reduce risk of second primary lung and breast cancer Open

Liesbeth Boersma, Arno C. Hessels, Sander Roberti, Enrica Seravalli, Nina Bijker , et al. · 2025

ABS0128 GENERATION OF PLURIPOTENT STEM CELL-DERIVED SALIVARY GLAND PROGENITOR CELLS FOR TRANSPLANTATION IN SJÖGREN'S DISEASE Open

Abel Soto-Gamez, Janneke H. Terpstra, C. Tesa, Hendrika Bootsma, F. G. M. Kroese , et al. · 2025

Establishment of salivary tissue-organoid biorepository: characterizing salivary gland stem/progenitor cells and novel differentiation marker PSMA/FOLH1 Open

Syed Mohammed Musheer Aalam, Ana Rita Varela, Aalim Khaderi, Ronsard J Mondesir, Dong‐Gi Mun , et al. · 2025

Development and validation of cost-effective multi-sample hypoxia chambers for proton ultra-high dose rate organoid irradiations Open

Ralf Köster, Jeremy P Gunawan, Hans Peters, Johan Bussink, Lara Barazzuol , et al. · 2025

Clinical applications of human organoids Open

Monique M.A. Verstegen, Robert P. Coppes, Anne Béghin, Paolo De Coppi, M Gerli , et al. · 2025

Notch Signaling Drives Pro-Regenerative and Migratory Traits in Glandular Stem/Progenitor cells Open

Davide Cinat, Rufina Maturi, Jeremy P Gunawan, Anne L. Jellema-de Bruin, Laura Kracht , et al. · 2024

Organoid models have advanced our understanding of adult stem/progenitor cell dynamics and function. However, uncovering the regulatory mechanisms of scarce and often quiescent stem cells in organs like the salivary glands remains challeng…

Driving innovation in radiation oncology in a changing world: The Green Journal’s roadmap for the next decade Open

Pierre Blanchard, Dietmar Georg, Robert P. Coppes, Birgitte Vrou Offersen · 2024

Future of Team-based Basic and Translational Science in Radiation Oncology Open

Robert P. Coppes, Lisanne V. van Dijk · 2024

Pursuing New Horizons With New Collaborators: This Is the Future of Radiation Oncology Open

David A. Jaffray, Robert P. Coppes, H. McNair, Akila N. Viswanathan · 2024

Sparing of the Heart Facilitates Recovery From Cardiopulmonary Side Effects After Thoracic Irradiation Open

Julia Wiedemann, Sai K Paruchuru, Lisette E. den Boef, Uilke Brouwer, Herman H.W. Silljé , et al. · 2024

Combined irradiation of lung and heart leads to an intensified, persistent reduction of cardiopulmonary function. Recovery of the pulmonary vasculature and RV function requires heart sparing.

Small Molecule MIF Modulation Enhances Ferroptosis by Impairing DNA Repair Mechanisms Open

Deng Chen, Chunlong Zhao, Jianqiu Zhang, Catharina W. J. Knol, Angelina Osipyan , et al. · 2024

Ferroptosis is a form of regulated cell death that can be modulated by small molecules and has the potential for the development of therapeutics for oncology. Although excessive lipid peroxidation is the defining hallmark of ferroptosis, D…

Radiation-induced DNA double-strand breaks in cortisol exposed fibroblasts as quantified with the novel foci-integrated damage complexity score (FIDCS) Open

Wilhelmina E. Radstake, Alessio Parisi, Silvana Miranda, Kiran Gautam, Randy Vermeesen , et al. · 2024

Radiation-induced Xerostomia is Related to Stem Cell Dose-dependent Reduction of Saliva Production Open

Maria I. van Rijn–Dekker, Sacha la Bastide‐van Gemert, Monique A. Stokman, Arjan Vissink, Robert P. Coppes , et al. · 2024

Organoid-based personalized medicine: from tumor outcome prediction to autologous transplantation Open

Abel Soto-Gamez, Jeremy P Gunawan, Lara Barazzuol, Sarah Pringle, Robert P. Coppes · 2024

Inter-individual variation largely influences disease susceptibility, as well as response to therapy. In a clinical context, the optimal treatment of a disease should consider inter-individual variation and formulate tailored decisions at …

Optimization of the Production Process of Clinical-Grade Human Salivary Gland Organoid-Derived Cell Therapy for the Treatment of Radiation-Induced Xerostomia in Head and Neck Cancer Open

Jacoba van Zanten, Annelies Jorritsma‐Smit, Hans H. Westra, Mirjam Baanstra, Anne de Bruin-Jellema , et al. · 2024

Head and neck cancer is a common cancer worldwide. Radiotherapy has an essential role in the treatment of head and neck cancers. After irradiation, early effects of reduced saliva flow and hampered water secretion are seen, along with cell…

Proton therapy induces a local microglial neuroimmune response Open

Daniëlle C. Voshart, Myrthe Klaver, Yuting Jiang, Hilmar R. J. van Weering, Fleur van Buuren-Broek , et al. · 2024

The Mayo Clinic Salivary Tissue-Organoid Biobanking: A Resource for Salivary Regeneration Research Open

Syed Mohammed Musheer Aalam, Ana Rita Varela, Aalim Khaderi, Ronsard J Mondesir, Dong‐Gi Mun , et al. · 2024

The salivary gland (SG) is an essential organ that secretes saliva, which supports versatile oral function throughout life, and is maintained by elusive epithelial stem and progenitor cells (SGSPC). Unfortunately, aging, drugs, autoimmune …

Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome Open

Felix Broghammer, Irina Korovina, Mahesh Gouda, Martina Celotti, Johan H. van Es , et al. · 2024

Background Focal adhesion signaling involving receptor tyrosine kinases (RTK) and integrins co-controls cancer cell survival and therapy resistance. However, co-dependencies between these receptors and therapeutically exploitable vulnerabi…

Transposable Element Derepression-mediated IFN-I Signaling Enhances Stem/Progenitor Cell Activity After Irradiation Open

Davide Cinat, Ryan van der Wal, Mirjam Baanstra, Abel Soto-Gamez, Anne L. Jellema-de Bruin , et al. · 2024

Radiotherapy is a mainstay in cancer treatment, aiming to maximize DNA damage in tumors while minimizing harm to surrounding healthy tissues. However, the collateral damage to normal tissues, especially stem/progenitor cells essential for …

Radiotherapy induces persistent innate immune reprogramming of microglia into a primed state Open

Daniëlle C. Voshart, Takuya Oshima, Yuting Jiang, Gideon P. van der Linden, Anna Ainslie , et al. · 2024

Clinical research for global needs of radiation oncology Open

Michaël Baumann, Carol Bacchus, Marianne Aznar, Robert P. Coppes, Éric Deutsch , et al. · 2023

MET-receptor targeted fluorescent imaging and spectroscopy to detect multifocal papillary thyroid cancer Open

Madelon J. H. Metman, Pascal Jonker, Luc Sondorp, Bettien M. van Hemel, Mark Sywak , et al. · 2023

Purpose Multifocal disease in PTC is associated with an increased recurrence rate. Multifocal disease (MD) is underdiagnosed with the current gold standard of pre-operative ultrasound staging. Here, we evaluate the use of EMI-137 targeted …

Mitophagy induction improves salivary gland stem/progenitor cell function by reducing senescence after irradiation Open

Davide Cinat, Anna Lena De Souza, Abel Soto-Gamez, Anne L. Jellema-de Bruin, Robert P. Coppes , et al. · 2023

Mesenchymal stem cell-derived HGF attenuates radiation-induced senescence in salivary glands via compensatory proliferation Open

Abel Soto-Gamez, Michael A. van Es, Elizabeth Hageman, Sandra Serna Salas, Han Moshage , et al. · 2023

ADSCs may positively influence radiation recovery through HGF secretion and can promote the ex vivo expansion of salivary gland stem/progenitor cells to enhance the effects of co-transplanted SGSC.

Patient-Derived Medullary Thyroid Cancer Organoids; a Model for Patient-tailored Drug and PET-Tracer Screening Open

Luc Sondorp, Eline Jager, Inês F. Antunes, Rufina Maturi, Liesbeth Jansen , et al. · 2023

Background Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor derived from the parafollicular C-cells of the thyroid gland. PET imaging, with various PET tracers, is performed when distant metastatic disease is suspected. After th…

Contents Open

M Baumann, Carol Bacchus, Marianne Aznar, Robert P. Coppes, E Deutsch , et al. · 2023

Radiotherapy induces persistent innate immune reprogramming of microglia into a primed state Open

Daniëlle C. Voshart, Takuya Oshima, Yuting Jiang, Gideon P. van der Linden, Anna Ainslie , et al. · 2023

Summary More than half of all brain tumour survivors experience debilitating and often progressive cognitive decline after treatment with radiotherapy. Microglia, the resident macrophages in the brain, have been implicated in this decline.…

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