Explanipedia

Improving Virtual Contrast Enhancement using Longitudinal Data Open

Pierre Fayolle, Alexandre Bône, Noëlie Debs, Philippe Robert, Pascal Bourdon , et al. · 2025

Gadolinium-based contrast agents (GBCAs) are widely used in magnetic resonance imaging (MRI) to enhance lesion detection and characterisation, particularly in the field of neuro-oncology. Nevertheless, concerns regarding gadolinium retenti…

Overall Gadolinium Exposure Within the First 5 Months After Injection of Human Equivalent Doses of Gadopiclenol, Gadoterate, or Gadobutrol in Healthy Rats Open

Marlène Rasschaert, Emilie Couloumy, Elisabeth Renard, Claire Hollenbeck, Nathalie Fretellier , et al. · 2025

Introduction: Gadopiclenol is a high relaxivity macrocyclic and nonionic Gadolinium-Based Contrast Agent (GBCA) for central nervous system (CNS) and Body MRI, approved in September 2022 by the Food and Drug Administration and in December 2…

Micro-CT and histological assessment of renal arterial embolization with Glubran®2 cyanoacrylate: a medium-term follow-up study in a rabbit model Open

Romaric Loffroy, Kévin Guillen, Olivier Chevallier, Mohamed Fouad, Emilie Couloumy , et al. · 2025

Background Cyanoacrylate glues are widely used in interventional radiology as effective embolic agents due to their rapid polymerization and ability to achieve vessel occlusion. Nonetheless, concern remains regarding cast stability and pot…

Micro-CT and Histological Assessment of Renal Arterial Embolization with Glubran®2 Cyanoacrylate: A Medium-Term Follow-Up Study in a Rabbit Model Open

Romaric Loffroy, Kévin Guillen, Olivier Chevallier, Mohamed Fouad, Emilie Couloumy , et al. · 2025

Background Cyanoacrylate glues are widely used in interventional radiology as effective embolic agents due to their rapid polymerization and ability to achieve vessel occlusion. Nonetheless, concern remains regarding cast stability and pot…

Detecting childhood trauma in MDD patients through automated speech and language analysis Open

Alexandra König, Éric Ettore, Holly Lindsay, Johannes Tröger, Michel Benoît , et al. · 2025

Introduction Speech patterns offer valuable insights into cognitive and emotional states, particularly in mental health conditions such as Major Depressive Disorder (MDD). Traditional assessments often fail to capture its full severity, pr…

Evaluation of the Contrast Enhancement Performance of Gadopiclenol for Magnetic Resonance Angiography in Healthy Rabbits and Pigs Open

Gaëlle Hugon, Hans Adriaensen, Mélody Wintrebert, Laurent Arnould, Jean‐Michel Serfaty , et al. · 2024

Objectives Unexpected accumulations of gadolinium in various organs were reported after the administration of gadolinium-based contrast agents, making desirable to reduce the dose while maintaining equivalent diagnostic performance. The ai…

Antitumoral effect of local injection of TLR-9 agonist emulsified in Lipiodol with systemic anti-PD-1 in a murine model of colorectal carcinoma Open

Anne-Laure Grindel, Nathalie Fretellier, Miguel Luz Soares, Nabiha Bouzakher, Vincent Millot Maysounabe , et al. · 2024

Introduction Local treatments of cancer, including transarterial chemoembolization, could enhance responses to systemic immune checkpoint inhibitors such as anti-PD-1 antibodies. Lipiodol, a radiopaque oil, is widely used for transarterial…

Blocked-flow vs. free-flow cyanoacrylate glue embolization: Histological differences in an in vivo rabbit renal artery model Open

Pierre‐Olivier Comby, Kévin Guillen, Olivier Chevallier, Emilie Couloumy, Anne Dencausse , et al. · 2023

From Dose Reduction to Contrast Maximization Open

Alexandre Bône, Samy Ammari, Y. Menu, Corinne Balleyguier, Eric Moulton , et al. · 2022

Objectives The aim of this study was to evaluate a deep learning method designed to increase the contrast-to-noise ratio in contrast-enhanced gradient echo T1-weighted brain magnetic resonance imaging (MRI) acquisitions. The processed imag…

Small Brain Lesion Enhancement and Gadolinium Deposition in the Rat Brain: Comparison Between Gadopiclenol and Gadobenate Dimeglumine. Open

Xavier Violas, Marlène Rasschaert, Robin Santus, Cécile Factor, Claire Corot , et al. · 2022

In the small brain lesion rat model, gadopiclenol provides significantly higher enhancement of brain lesions compared with gadobentate dimeglumine at the same dose. After repeated IV injections, as expected for a macrocyclic GBCA, Gd reten…

Small Brain Lesion Enhancement and Gadolinium Deposition in the Rat Brain Open

Xavier Violas, Marlène Rasschaert, Robin Santus, Cécile Factor, Claire Corot , et al. · 2021

Objectives The aim of the set of studies was to compare gadopiclenol, a new high relaxivity gadolinium (Gd)–based contrast agent (GBCA) to gadobenate dimeglumine in terms of small brain lesion enhancement and Gd retention, including T1 enh…

BiPSim: a flexible and generic stochastic simulator for polymerization processes Open

Stephan Fischer, Marc Dinh, Vincent Henry, Philippe Robert, Anne Goelzer , et al. · 2021

Reduced nontarget embolization and increased targeted delivery with a reflux-control microcatheter in a swine model Open

Silvia Rizzitelli, Nir Holtzman, Geert Maleux, Thierry de Baère, Fei Sun , et al. · 2021

In an animal model, RCM microcatheters reduce the risk of non-target embolization from 11% to 1.7%, increasing the delivery of microspheres of 98% to the target vessels, compared to SEHM microcatheters.

Speciation Analysis of Gadolinium in the Water-Insoluble Rat Brain Fraction After Administration of Gadolinium-Based Contrast Agents Open

Izabela Strzeminska, Cécile Factor, Philippe Robert, Joanna Szpunar, Claire Corot , et al. · 2021

Purpose To date, the analysis of gadolinium (Gd) speciation in the brain of animals administered with macrocyclic and linear Gd-based contrast agents (GBCAs) has been limited to Gd soluble in mild buffers. Under such conditions, less than …

Long-Term Evaluation of Gadolinium Retention in Rat Brain After Single Injection of a Clinically Relevant Dose of Gadolinium-Based Contrast Agents Open

Izabela Strzeminska, Cécile Factor, Philippe Robert, Anne-Laure Grindel, Pierre‐Olivier Comby , et al. · 2020

Purpose The aim of this study was to investigate the presence and chemical forms of residual gadolinium (Gd) in rat brain after a single dose of Gd-based contrast agent. Methods Four groups of healthy rats (2 sacrifice time-points, n = 10/…

Application of Virtual Travel for Alzheimer’s Disease Open

Hamdi Ben Abdessalem, Alexie Byrns, Marc Cuesta, Valéria Manera, Philippe Robert , et al. · 2020

Effect of Long-Term Retention of Gadolinium on Metabolism of Deep Cerebellar Nuclei After Repeated Injections of Gadodiamide in Rats Open

Dounia El Hamrani, Véronique Vivès, Rebecca Buchholz, William Même, Cécile Factor , et al. · 2019

Objectives The aim of this study was to determine potential metabolism and histological modifications due to gadolinium retention within deep cerebellar nuclei (DCN) after linear gadolinium-based contrast agent injection (gadodiamide) in r…

Contrast-to-Dose Relationship of Gadopiclenol, an MRI Macrocyclic Gadolinium-based Contrast Agent, Compared with Gadoterate, Gadobenate, and Gadobutrol in a Rat Brain Tumor Model Open

Philippe Robert, Véronique Vivès, Anne-Laure Grindel, Stéphane Kremer, Guillaume Bierry , et al. · 2019

Background Detection of cerebral lesions at MRI may benefit from a chemically stable and more sensitively detected gadolinium-based contrast agent (GBCA). Gadopiclenol, a macrocyclic GBCA with at least twofold higher relaxivity, is current…

Assessment and Staging of Care for People with Dementia: The IDEAL Schedule and its User Manual Open

Maya Semrau, Alistair Burns, António Lobo, Marcel G. M. Olde Rikkert, Philippe Robert , et al. · 2019

Assessment and Staging of Care for Dementia: The IDEAL schedule and its user manual is a unique resource containing a global clinical staging schedule for dementia alongside essential, practical information on how to use it. The Internatio…

Language Modelling for the Clinical Semantic Verbal Fluency Task Open

Nicklas Linz, Johannes Tröger, Hali Lindsay, Alexandra König, Philippe Robert , et al. · 2019

International audience

Does Age Interfere With Gadolinium Toxicity and Presence in Brain and Bone Tissues? Open

Nathalie Fretellier, Agnès Granottier, Marlène Rasschaert, Anne-Laure Grindel, Fannie Baudimont , et al. · 2018

Objectives The main objective of the study was to assess the effect of age on target tissue total gadolinium (Gd) retention after repeated administration of gadodiamide (linear) or gadoterate (macrocyclic) Gd-based contrast agent (GBCA) in…

One-year Retention of Gadolinium in the Brain: Comparison of Gadodiamide and Gadoterate Meglumine in a Rodent Model Open

Philippe Robert, Stefanie Fingerhut, Cécile Factor, Véronique Vivès, Justine Letien , et al. · 2018

Purpose To compare the long-term brain elimination kinetics and gadolinium species in healthy rats after repeated injections of the contrast agents gadodiamide (a linear contrast agent) or gadoterate (a macrocyclic contrast agent). Materia…

Methodological Aspects for Preclinical Evaluation of Gadolinium Presence in Brain Tissue Open

Philippe Robert, Thomas Frenzel, Cécile Factor, Gregor Jošt, Marlène Rasschaert , et al. · 2018

Gadolinium (Gd)-based contrast agents (GBCAs) are pharmaceuticals that have been approved for 30 years and used daily in millions of patients worldwide. Their clinical benefits are indisputable. Recently, unexpected long-term presence of G…

Gadolinium Retention, Brain T1 Hyperintensity, and Endogenous Metals Open

Marlène Rasschaert, Andréa Emerit, Nathalie Fretellier, Cécile Factor, Philippe Robert , et al. · 2018

Objectives This preclinical study was designed to compare gadolinium (Gd) brain uptake after repeated injections of a macrocyclic Gd-based contrast agent (GBCA) (gadoterate meglumine) or 2 linear GBCAs (L-GBCAs) (gadobenate dimeglumine or …

Alzheimer’s Disease Modelling and Staging Through Independent Gaussian Process Analysis of Spatio-Temporal Brain Changes Open

Clément Abi Nader, Nicholas Ayache, Philippe Robert, Marco Lorenzi · 2018

Molecular Magnetic Resonance and Ultra Sound Imaging of Tumor Angiogenesis Open

Marie Poirier‐Quinot, Ingrid Leguerney, Ludovic de Rochefort, Stéphanie Pitre-Champagnat, Xavier Violas , et al. · 2017

Seeking out and identifying imaging biomarkers for early cancer diagnosis and the evaluation of patient response to therapy requires an improvement in the specificity of imaging techniques. This study explores in vivo neo-angiogenesis asse…

Predicting Dementia Screening and Staging Scores from Semantic Verbal Fluency Performance Open

Nicklas Linz, Johannes Tröger, Jan Alexandersson, Maria Wolters, Alexandra König , et al. · 2017

International audience

Molecular Magnetic Resonance and Ultrasound Imaging of Tumor Angiogenesis Open

Marie Poirier‐Quinot, Ingrid Leguerney, Ludovic de Rochefort, Stéphanie Pitre-Champagnat, Xavier Violas , et al. · 2017

International audience

Molecular Imaging to Predict Response to Targeted Therapies in Renal Cell Carcinoma Open

Ingrid Leguerney, Ludovic de Rochefort, Marie Poirier‐Quinot, Alexandre Ingels, Xavier Violas , et al. · 2017

Molecular magnetic resonance imaging targeted to an endothelial integrin involved in neoangiogenesis was compared to DCE-US and immunochemistry to assess the early response of three different therapeutic agents in renal cell carcinoma. Hum…

Moderate Renal Failure Accentuates T1 Signal Enhancement in the Deep Cerebellar Nuclei of Gadodiamide-Treated Rats Open

Marlène Rasschaert, Jean‐Marc Idée, Philippe Robert, Nathalie Fretellier, Véronique Vivès , et al. · 2016

Objectives The purpose of this preclinical study was to investigate whether moderate chronic kidney disease is a factor in potentiating gadolinium (Gd) uptake in the brain. Materials and Methods A comparative study was performed on renally…

Philippe Robert YOU? Author Swipe