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View article: Distinct Cellular Immune Responses to SARS-CoV-2 in Pregnant Women
Distinct Cellular Immune Responses to SARS-CoV-2 in Pregnant Women Open
Pregnant women are at increased risk of adverse outcomes, including preeclampsia and preterm birth, that may result from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Pregnancy imprints specific maternal immune re…
View article: IL-22 Plays a Dual Role in the Amniotic Cavity: Tissue Injury and Host Defense against Microbes in Preterm Labor
IL-22 Plays a Dual Role in the Amniotic Cavity: Tissue Injury and Host Defense against Microbes in Preterm Labor Open
IL-22 is a multifaceted cytokine with both pro- and anti-inflammatory functions that is implicated in multiple pathologies. However, the role of IL-22 in maternal-fetal immunity in late gestation is poorly understood. In this study, we fir…
View article: A single-cell atlas of the myometrium in human parturition
A single-cell atlas of the myometrium in human parturition Open
Parturition is a well-orchestrated process characterized by increased uterine contractility, cervical ripening, and activation of the chorioamniotic membranes; yet, the transition from a quiescent to a contractile myometrium heralds the on…
View article: The Distinct Immune Nature of the Fetal Inflammatory Response Syndrome Type I and Type II
The Distinct Immune Nature of the Fetal Inflammatory Response Syndrome Type I and Type II Open
Fetal inflammatory response syndrome (FIRS) is strongly associated with neonatal morbidity and mortality and can be classified as type I or type II. Clinically, FIRS type I and type II are considered as distinct syndromes, yet the molecula…
View article: Betamethasone as a potential treatment for preterm birth associated with sterile intra-amniotic inflammation: a murine study
Betamethasone as a potential treatment for preterm birth associated with sterile intra-amniotic inflammation: a murine study Open
Objectives Preterm birth remains the leading cause of perinatal morbidity and mortality worldwide. Preterm birth is preceded by spontaneous preterm labor, which is commonly associated with sterile intra-amniotic inflammation; yet, no appro…
View article: Maternal-Fetal Immune Responses in Pregnant Women Infected with SARS-CoV-2
Maternal-Fetal Immune Responses in Pregnant Women Infected with SARS-CoV-2 Open
Pregnant women are a high-risk population for severe/critical COVID-19 and mortality. However, the maternal-fetal immune responses initiated by SARS-CoV-2 infection, and whether this virus is detectable in the placenta, are still under inv…
View article: Resolution of acute cervical insufficiency after antibiotics in a case with amniotic fluid sludge
Resolution of acute cervical insufficiency after antibiotics in a case with amniotic fluid sludge Open
Cervical insufficiency generally refers to a condition in which there is mid-trimester cervical dilatation or protruding chorioamniotic membranes in the absence of uterine contractions. Such condition is a risk factor for spontaneous mid-t…
View article: Resolution of acute cervical insufficiency after antibiotics in a case with amniotic fluid sludge
Resolution of acute cervical insufficiency after antibiotics in a case with amniotic fluid sludge Open
Cervical insufficiency generally refers to a condition in which there is mid-trimester cervical dilatation or protruding chorioamniotic membranes in the absence of uterine contractions. Such condition is a risk factor for spontaneous mid-t…
View article: Cellular immune responses in amniotic fluid of women with a sonographic short cervix
Cellular immune responses in amniotic fluid of women with a sonographic short cervix Open
Objectives A sonographic short cervix is one of the strongest predictors of preterm delivery. However, the cellular immune composition of amniotic fluid in women with a short cervix has not yet been described. Herein, we determined cellula…
View article: Intra-Amniotic Infection with <i>Ureaplasma parvum</i> Causes Preterm Birth and Neonatal Mortality That Are Prevented by Treatment with Clarithromycin
Intra-Amniotic Infection with <i>Ureaplasma parvum</i> Causes Preterm Birth and Neonatal Mortality That Are Prevented by Treatment with Clarithromycin Open
Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. Multiple etiologies are associated with preterm birth; however, 25% of preterm infants are born to a mother with intra-amniotic infection, most commonly due …
View article: Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes
Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes Open
Background Preterm birth is the leading cause of perinatal morbidity and mortality. Preterm prelabor rupture of membranes (pPROM) occurs in 30% of preterm births; thus, this complication is a major contributor to maternal and neonatal morb…
View article: Maternal circulating concentrations of soluble Fas and Elabela in early- and late-onset preeclampsia
Maternal circulating concentrations of soluble Fas and Elabela in early- and late-onset preeclampsia Open
The Fas/Fas ligand (FASL) system and Elabela-apelin receptor signaling pathways are implicated in the pathophysiology of preeclampsia. The aim of the current study was to investigate whether a model combining the measurement of sFas and El…
View article: Microbial burden and inflammasome activation in amniotic fluid of patients with preterm prelabor rupture of membranes
Microbial burden and inflammasome activation in amniotic fluid of patients with preterm prelabor rupture of membranes Open
Background Intra-amniotic inflammation, which is associated with adverse pregnancy outcomes, can occur in the presence or absence of detectable microorganisms, and involves activation of the inflammasome. Intra-amniotic inflammasome activa…
View article: Fetal T Cell Activation in the Amniotic Cavity during Preterm Labor: A Potential Mechanism for a Subset of Idiopathic Preterm Birth
Fetal T Cell Activation in the Amniotic Cavity during Preterm Labor: A Potential Mechanism for a Subset of Idiopathic Preterm Birth Open
Prematurity is the leading cause of perinatal morbidity and mortality worldwide. In most cases, preterm birth is preceded by spontaneous preterm labor, a syndrome that is associated with intra-amniotic inflammation, the most studied etiolo…
View article: Cellular immune responses in amniotic fluid of women with preterm labor and intra‐amniotic infection or intra‐amniotic inflammation
Cellular immune responses in amniotic fluid of women with preterm labor and intra‐amniotic infection or intra‐amniotic inflammation Open
Problem Preterm birth is commonly preceded by preterm labor, a syndrome that is causally linked to both intra‐amniotic infection and intra‐amniotic inflammation. However, the stereotypical cellular immune responses in these two clinical co…
View article: Gasdermin D:<i>in vivo</i>evidence of pyroptosis in spontaneous labor at term
Gasdermin D:<i>in vivo</i>evidence of pyroptosis in spontaneous labor at term Open
Objective: Pyroptosis is an inflammatory form of programmed cell death that is mediated by the activation of the inflammasome and depends on the pore-forming function of gasdermin D. Therefore, the detection of gasdermin D represents in vi…
View article: Human β-defensin-3 participates in intra-amniotic host defense in women with labor at term, spontaneous preterm labor and intact membranes, and preterm prelabor rupture of membranes
Human β-defensin-3 participates in intra-amniotic host defense in women with labor at term, spontaneous preterm labor and intact membranes, and preterm prelabor rupture of membranes Open
Objective: Human β-defensin-3 (HBD-3) has a broad spectrum of antimicrobial activity, and activity and, therefore, plays a central role in host defense mechanisms against infection. Herein, we determined whether HBD-3 was a physiological c…