Robert Pecoraro
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View article: RNA sequence design and protein–DNA specificity prediction with NA-MPNN
RNA sequence design and protein–DNA specificity prediction with NA-MPNN Open
RNA sequence design and protein–DNA binding specificity prediction can both be framed as nucleic acid inverse-folding problems: finding the most likely nucleic acid sequences given a fixed three-dimensional structure of a nucleic acid or n…
View article: De novo design of RNA and nucleoprotein complexes
De novo design of RNA and nucleoprotein complexes Open
Nucleic acids fold into sequence-dependent tertiary structures and carry out diverse biological functions, much like proteins. However, while considerable advances have been made in the de novo design of protein structure and function, the…
View article: Atomic context-conditioned protein sequence design using LigandMPNN
Atomic context-conditioned protein sequence design using LigandMPNN Open
Protein sequence design in the context of small molecules, nucleotides and metals is critical to enzyme and small-molecule binder and sensor design, but current state-of-the-art deep-learning-based sequence design methods are unable to mod…
View article: Atomic context-conditioned protein sequence design using LigandMPNN
Atomic context-conditioned protein sequence design using LigandMPNN Open
Protein sequence design in the context of small molecules, nucleotides, and metals is critical to enzyme and small molecule binder and sensor design, but current state-of-the-art deep learning-based sequence design methods are unable to mo…
View article: Computational design of sequence-specific DNA-binding proteins
Computational design of sequence-specific DNA-binding proteins Open
Sequence-specific DNA-binding proteins (DBPs) play critical roles in biology and biotechnology, and there has been considerable interest in the engineering of DBPs with new or altered specificities for genome editing and other applications…