Explanipedia

Cognitively Unimpaired Older Adults with Type 2 Diabetes have Higher Levels of Plasma <i>p</i> ‐tau217 Open

Darian A. Napoleon, Bernadette A. Fausto, Wiktoria Piaszczynska, Ashley Powell, Stanley Romain , et al. · 2025

Medicine Psychology

Background Alzheimer's disease (AD) and type 2 diabetes (T2D) share common pathophysiological mechanisms and cognitive sequelae. A potential mechanism by which T2D raises AD risk among aging adults relates to alterations in the medial temp…

Lower plasma p‐tau levels and larger hippocampi may protect African American SuperAgers from age‐related cognitive decline and Alzheimer’s disease Open

Wiktoria Piaszczynska, Miray Budak, Bernadette A. Fausto, Pamela J. White, Robert Perna , et al. · 2024

Medicine Psychology Biology

Background Advancing age is typically associated with a decline in memory capacity and increased risk of Alzheimer’s disease (AD) 1 . However, there is a subgroup of the older adult population defined as SuperAgers that presents excellent …

Emotional, Behavioral, and Cognitive Symptom Associations With Community Participation in Chronic Traumatic Brain Injury Open

Shannon B. Juengst, Brittany Wright, Leia Vos, Robert Perna, Michael Williams , et al. · 2023

Psychology Medicine Biology

Objectives: To determine the association between self-reported emotional and cognitive symptoms and participation outcomes in chronic traumatic brain injury (TBI) and to explore the relative contribution of self-reported versus performance…

Anti-NMDA Encephalitis Cases Secondary to Teratoma and Pregnancy Open

Robert Perna · 2018

Medicine Biology

Anti-NMDA receptor (anti-NMDAR) encephalitis frequently develops in young women [1] and can be related to an autoimmune reaction to pregnancy or an ovarian teratoma. Severe new onset psychiatric symptoms and/or seizures in young adult wome…

Psychosocial issues associated with stroke Open

Robert Perna, Jessica Le · 2018

Psychology Medicine Engineering

physical impairments such as hemiplegia or language problems such as aphasia, but over time the stress and burden of the situation often takes a toll on the individual's mood and caregivers.

Race and Post-acute Stroke Recovery: More Similarities than Differences Open

Robert Perna · 2017

Medicine Psychology Biology

Race is a significant variable in terms of some health outcomes.Research has produced mixed findings in regards to the influence of race membership and rehabilitation outcomes from cardiovascular insults.More extensive research focused on …

Nature (Genes), Nurture (Epigenetics), and Brain Development Open

Robert Perna · 2017

Medicine Biology

Behavioral geneticists commonly claim that DNA accounts for 30 to 50 percent of our behaviors, 3 which leaves 50 to 70 percent explained by environment.It is now clear that there is a dynamic interplay between genes and environmental influ…

Case series of adults with Moyamoya-related stroke and rehabilitation outcomes. Open

Robert Perna, Joanne McGee · 2017

Medicine Engineering

Moyamoya disease is a rare cerebrovascular syndrome characterized by progressive stenosis and occlusion of the internal carotid arteries and other circle of Willis blood vessels. There is a growing body of research on Moyamoya, but very li…

C-30Caregiver Training to Facilitate Improved Brain Injury Rehabilitation Open

Robert Perna, Joshua E. McGee, J Pundlike · 2016

Psychology Medicine Geography

Objective: Caregiving after acquired brain injury is challenging, can correlate with long-term outcome and may require training to be effective.Some brain injury rehabilitation programs offer support groups/training as a resource for careg…

Recovery from Pediatric Acquired Brain Injury: A Guarded Prognosis Open

Robert Perna · 2016

Medicine

injury.

Limbic Encephalitis: Complex Presentation and Course Open

Robert Perna · 2016

Medicine Physics

Limbic encephalitis is often associated with NMDA antibodies.NMDA receptors are highly expressed in the forebrain, limbic system, and hypothalamus, and play a role in synaptic transmission and plasticity. 3,4In NMDA receptor encephalitis, …

Comorbidity and Diagnosing Developmental Disorders Open

Robert Perna · 2016

Medicine

Neurodevelopmental disorders are now known to have a higher incidence and higher rate of comorbidities than conditions more frequently than would be expected by chance.In the past, comorbidity was thought to be the exception whereas it now…

Editorial: Post-stroke Angiogenesis and Treatment Potential Open

Robert Perna · 2016

Medicine Engineering Biology

Vascular science is progressing rapidly and current research methodologies are facilitating the testing of many potential treatments for vascular disease. One fascinating area of research with great potential for clinical implications is a…

Internal Memory Rehabilitation Strategies in the Context of Post-acute Brain Injury: A Pilot Study Open

Robert Perna, Hana Perkey · 2016

Psychology Medicine Biology

Memory impairments are one of the most common consequences of acquired brain injury. Poor memory can have a severe impact on a person’s daily functioning and his/her quality of life. While research provides some support for using external,…

Treatment of Depression Following a Traumatic Brain Injury Open

Robert Perna · 2015

Psychology Medicine Economics

Brief overview of Depression Associated with Brain InjuryBrain injury can and often does carry heavy cost for its survivors in terms of physical impairments, cognitive difficulties, and psychosocial dysfunction. 1 One of the most common ps…

Rehabilitation Outcomes: Ischemic versus Hemorrhagic Strokes Open

Robert Perna, Jessica Temple · 2015

Medicine Engineering

Background . Ischemic and hemorrhagic strokes have different pathophysiologies and possibly different long-term cerebral and functional implications. Hemorrhagic strokes expose the brain to irritating effects of blood and ischemic strokes …

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