Justin R. Cross
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View article: Supplementary Data TS1-4 from Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets
Supplementary Data TS1-4 from Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets Open
Supplementary Table S1-S4
View article: Dietary fiber intake improves survival in allogeneic HCT patients and exhibits synergistic effects with taurine supplementation in preclinical models
Dietary fiber intake improves survival in allogeneic HCT patients and exhibits synergistic effects with taurine supplementation in preclinical models Open
Background Dietary fiber modulates the intestinal microbiome, enhancing production of short-chain fatty acids (SCFAs) and bile acids (BAs), which support intestinal homeostasis. To assess its impact on acute graft-versus-host disease (aGVH…
View article: Identifying Mycobacterium tuberculosis-derived MR1 ligands and the MAIT cell response 2826
Identifying Mycobacterium tuberculosis-derived MR1 ligands and the MAIT cell response 2826 Open
Description Tuberculosis caused by Mycobacterium tuberculosis (Mtb) is the leading cause of infectious disease-related deaths. Mtb has evolved resistance to antimicrobials necessitating new approaches to anti-TB therapy. Our study focuses …
View article: Macropinocytosis enables metabolic recycling of extracellular DNA in cancer cells
Macropinocytosis enables metabolic recycling of extracellular DNA in cancer cells Open
Avid nutrient consumption is a metabolic hallmark of cancer and leads to regional depletion of key metabolites within the tumor microenvironment (TME). Cancer cells consequently employ diverse strategies to acquire the fuels needed for gro…
View article: Intracellular acidification by bacteria-derived valeric acid is a mechanism of trans-kingdom ecology against <i>Candida parapsilosis</i> colonization
Intracellular acidification by bacteria-derived valeric acid is a mechanism of trans-kingdom ecology against <i>Candida parapsilosis</i> colonization Open
In hematopoietic cell transplant patients, intestinal Candida parapsilosis expansion and translocation cause life-threatening candidemia, yet how commensal intestinal bacteria prevent Candida expansion remains incompletely defined. Here, w…
View article: Author Correction: Autotaxin–lysolipid signaling suppresses a CCL11–eosinophil axis to promote pancreatic cancer progression
Author Correction: Autotaxin–lysolipid signaling suppresses a CCL11–eosinophil axis to promote pancreatic cancer progression Open
View article: Publisher Correction: Metabolic adaptations direct cell fate during tissue regeneration
Publisher Correction: Metabolic adaptations direct cell fate during tissue regeneration Open
View article: Metabolic adaptations direct cell fate during tissue regeneration
Metabolic adaptations direct cell fate during tissue regeneration Open
Although cell-fate specification is generally attributed to transcriptional regulation, emerging data also indicate a role for molecules linked with intermediary metabolism. For example, α-ketoglutarate (αKG), which fuels energy production…
View article: A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity via engineered Gro3P-Glycerol shunt
A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity via engineered Gro3P-Glycerol shunt Open
Dihydroxyacetone phosphate (DHAP), glycerol-3-phosphate (Gro3P) and reduced/oxidized nicotinamide adenine dinucleotide (NADH/NAD + ) are key metabolites of the Gro3P shuttle system that forms a redox circuit, allowing transfer of reducing …
View article: MEK-dependent bioenergetic demand drives terminal CD8<sup>+</sup>T cell exhaustion
MEK-dependent bioenergetic demand drives terminal CD8<sup>+</sup>T cell exhaustion Open
SUMMARY Loss of mitochondrial function contributes to CD8 + T cell dysfunction during persistent antigen encounter. How chronic antigen leads to this metabolic dysfunction remains unclear. Here, we show that TCR-dependent mitochondrial NAD…
View article: Intratumoral amino acid insufficiency limits CD8<sup>+</sup>T-cell effector function
Intratumoral amino acid insufficiency limits CD8<sup>+</sup>T-cell effector function Open
Loss of effector function is a hallmark of tumor-infiltrating CD8 + T-cells that have lost therapeutic efficacy. This impaired capacity occurs despite expression of transcripts encoding cytotoxic proteins, raising the possibility that post…
View article: A High-Fiber Plant-Based Intervention in Precursor Plasma Cell Disorders Improves Dietary Quality and Microbiome
A High-Fiber Plant-Based Intervention in Precursor Plasma Cell Disorders Improves Dietary Quality and Microbiome Open
View article: Sperm meet the elevated energy demands to attain fertilization competence by increasing flux through aldolase
Sperm meet the elevated energy demands to attain fertilization competence by increasing flux through aldolase Open
Prior to ejaculation, sperm are stored in the epididymis in a ‘resting’ metabolic state. Upon ejaculation, sperm must alter their metabolism to generate the energy needed to support the motility and maturation process known as capacitation…
View article: Fission yeast metabolome dynamics during phosphate starvation and replenishment
Fission yeast metabolome dynamics during phosphate starvation and replenishment Open
Inorganic phosphate is an essential nutrient acquired by cells from their environment and assimilated into myriad intracellular metabolites and macromolecules. Here, we characterize the metabolic responses of fission yeast to a 24 h interv…
View article: Gut microbiota-derived hexa-acylated lipopolysaccharides enhance cancer immunotherapy responses
Gut microbiota-derived hexa-acylated lipopolysaccharides enhance cancer immunotherapy responses Open
View article: α-Ketoglutarate dehydrogenase is a therapeutic vulnerability in acute myeloid leukemia
α-Ketoglutarate dehydrogenase is a therapeutic vulnerability in acute myeloid leukemia Open
Perturbations in intermediary metabolism contribute to the pathogenesis of acute myeloid leukemia (AML) and can produce therapeutically actionable dependencies. Here, we probed whether α-ketoglutarate (αKG) metabolism represents a specific…
View article: 602 High fiber dietary intervention in plasma cell disorders improves microbiome and immune biomarkers and delays progression to myeloma
602 High fiber dietary intervention in plasma cell disorders improves microbiome and immune biomarkers and delays progression to myeloma Open
View article: 1271 Hexa-acylated lipopolysaccharides from the gut microbiota enhance cancer immunotherapy responses
1271 Hexa-acylated lipopolysaccharides from the gut microbiota enhance cancer immunotherapy responses Open
View article: Supplementary Data TS1-4 from Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets
Supplementary Data TS1-4 from Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets Open
Supplementary Table S1-S4
View article: Supplementary fig 1 from Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets
Supplementary fig 1 from Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets Open
Supplementary Figure S1. Volcano plot showing the difference in the relative abundance of butyrate producers between sustained MRD negative and MRD positive/non-sustained MRD negative.
View article: Supplementary fig 1 from Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets
Supplementary fig 1 from Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets Open
Supplementary Figure S1. Volcano plot showing the difference in the relative abundance of butyrate producers between sustained MRD negative and MRD positive/non-sustained MRD negative.
View article: Supplementary Data TS1-4 from Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets
Supplementary Data TS1-4 from Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets Open
Supplementary Table S1-S4
View article: Characterization, Structure, and Inhibition of the Human Succinyl-CoA:glutarate-CoA Transferase, a Putative Genetic Modifier of Glutaric Aciduria Type 1
Characterization, Structure, and Inhibition of the Human Succinyl-CoA:glutarate-CoA Transferase, a Putative Genetic Modifier of Glutaric Aciduria Type 1 Open
Glutaric Aciduria Type 1 (GA1) is a serious inborn error of metabolism with no pharmacological treatments. A novel strategy to treat this disease is to divert the toxic biochemical intermediates to less toxic or nontoxic metabolites. Here,…
View article: Hexa-acylated lipopolysaccharides from the gut microbiota enhance cancer immunotherapy responses
Hexa-acylated lipopolysaccharides from the gut microbiota enhance cancer immunotherapy responses Open
Immune checkpoint inhibitors (ICI), such as anti-PD-1, have revolutionized cancer treatment, but they are only effective for a minority of patients. The gut microbiome plays a crucial role in modulating immunotherapy treatment responses, a…
View article: Plasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells
Plasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells Open
Professional phagocytes like neutrophils and macrophages tightly control what they consume, how much they consume, and when they move after cargo uptake. We show that plasma membrane abundance is a key arbiter of these cellular behaviors. …
View article: Altered microbial bile acid metabolism exacerbates T cell-driven inflammation during graft-versus-host disease
Altered microbial bile acid metabolism exacerbates T cell-driven inflammation during graft-versus-host disease Open
View article: Characterization, structure and inhibition of the human succinyl-CoA:glutarate-CoA transferase, a genetic modifier of glutaric aciduria type 1
Characterization, structure and inhibition of the human succinyl-CoA:glutarate-CoA transferase, a genetic modifier of glutaric aciduria type 1 Open
Glutaric Aciduria Type 1 (GA1) is a serious inborn error of metabolism with no pharmacological treatments. A novel strategy to treat this disease is to divert the toxic biochemical intermediates to less toxic or non-toxic metabolites. Here…
View article: Autotaxin–lysolipid signaling suppresses a CCL11–eosinophil axis to promote pancreatic cancer progression
Autotaxin–lysolipid signaling suppresses a CCL11–eosinophil axis to promote pancreatic cancer progression Open
Lipids and their modifying enzymes regulate diverse features of the tumor microenvironment and cancer progression. The secreted enzyme autotaxin (ATX) hydrolyzes extracellular lysophosphatidylcholine to generate the multifunctional lipid m…
View article: A High-Fiber Dietary Intervention (NUTRIVENTION) in Precursor Plasma Cell Disorders Improves Disease Biomarkers and Delays Progression to Myeloma
A High-Fiber Dietary Intervention (NUTRIVENTION) in Precursor Plasma Cell Disorders Improves Disease Biomarkers and Delays Progression to Myeloma Open
View article: In Celebration of Women in Molecular and Cellular Reproduction
In Celebration of Women in Molecular and Cellular Reproduction Open
it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed.The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge.Front…