Robert Ritch
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View article: Ab-Externo MicroShunt versus Trabeculectomy in Primary Open-Angle Glaucoma
Ab-Externo MicroShunt versus Trabeculectomy in Primary Open-Angle Glaucoma Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Homocysteine and Glaucoma
Homocysteine and Glaucoma Open
Elevated levels of homocysteine (Hcy), a non-proteinogenic amino acid, may lead to a host of manifestations across the biological systems, particularly the nervous system. Defects in Hcy metabolism have been associated with many neurodegen…
View article: Vascular parameters and endothelin-1 measurements in glaucoma patients with low- and high-tension optic disc hemorrhages
Vascular parameters and endothelin-1 measurements in glaucoma patients with low- and high-tension optic disc hemorrhages Open
This prospective study aimed to compare vascular parameters (endothelin-1 [ET-1] blood levels, laser Doppler imaging [LDI] of distal phalanxes, and nailfold capillaroscopy) between open-angle glaucoma patients with low- and high-tension op…
View article: Vascular Parameters and Endothelin 1 Measurements in Glaucoma Patients With Low and High-tension Optic Disc Hemorrhages
Vascular Parameters and Endothelin 1 Measurements in Glaucoma Patients With Low and High-tension Optic Disc Hemorrhages Open
Purpose: To compare vascular parameters, assessed by endothelin-1 (ET-1) blood levels, Laser Doppler Imaging (LDI) of distal phalanx, and nailfold capillaroscopy (NC), between open-angle glaucoma (OAG) patients with low (LTDH) and high-ten…
View article: Parapapillary choroidal microvascular density in acute primary angle-closure and primary open-angle glaucoma: an optical coherence tomography angiography study
Parapapillary choroidal microvascular density in acute primary angle-closure and primary open-angle glaucoma: an optical coherence tomography angiography study Open
Back ground/aims To determine whether parapapillary choroidal microvasculature (PPCMv) density, measured by optical coherence tomography angiography, differed between acute primary angle-closure (APAC), primary open-angle glaucoma (POAG) a…
View article: Distinguishing Healthy From Glaucomatous Eyes With Optical Coherence Tomography Global Circumpapillary Retinal Nerve Fiber Thickness in the Bottom 5th Percentile
Distinguishing Healthy From Glaucomatous Eyes With Optical Coherence Tomography Global Circumpapillary Retinal Nerve Fiber Thickness in the Bottom 5th Percentile Open
Précis: Two novel, quantitative metrics, and 1 traditional metric were able to distinguish between many, but not all healthy and glaucomatous eyes in the bottom 5th percentile of global circumpapillary retinal nerve fiber layer (cpRNFL) th…
View article: Blood pressure control and glaucoma risk in postmenopausal women: an analysis from the Women's Health Initiative
Blood pressure control and glaucoma risk in postmenopausal women: an analysis from the Women's Health Initiative Open
Objective: Individuals with elevated systolic blood pressure (BP) or low diastolic BP, whether or not on antihypertensive treatment, may be at higher risk for developing glaucoma. We aimed to investigate BP levels in relation to glaucoma r…
View article: Genome-Wide Association Study Identifies Two Common Loci Associated with Pigment Dispersion Syndrome/Pigmentary Glaucoma and Implicates Myopia in its Development
Genome-Wide Association Study Identifies Two Common Loci Associated with Pigment Dispersion Syndrome/Pigmentary Glaucoma and Implicates Myopia in its Development Open
Common SNPs relating to the GSAP and GRM5/TYR genes are associated risk factors for the development of PDS and PG. Although myopia is a known risk factor, this study uses genetic data to demonstrate that myopia is, in part, a cause of PDS …
View article: Association of Non-Melanoma Skin Carcinomas and UV Exposure with Exfoliation Syndrome in Utah
Association of Non-Melanoma Skin Carcinomas and UV Exposure with Exfoliation Syndrome in Utah Open
Background: Prior data suggest an association between non-melanoma skin cancer, i.e., basal and squamous cell cancers most often located in areas of sun exposure, and pseudoexfoliation syndrome. This study aimed to evaluate the association…
View article: Summary of Utah Project on Exfoliation Syndrome (UPEXS): using a large database to identify systemic comorbidities
Summary of Utah Project on Exfoliation Syndrome (UPEXS): using a large database to identify systemic comorbidities Open
The purpose of the Utah Project on Exfoliation Syndrome (UPEXS) is to identify associations between exfoliation syndrome (XFS) and other diseases that share the commonality of abnormalities in elastin and Lysyl Oxidase-Like 1 gene regulati…
View article: Distribution of rare <i>LOXL1</i> missense alleles, haplotypes and diplotypes suggests association with reduced risk of glaucoma-related exfoliation syndrome
Distribution of rare <i>LOXL1</i> missense alleles, haplotypes and diplotypes suggests association with reduced risk of glaucoma-related exfoliation syndrome Open
Purpose Common LOXL1 protein-altering variants are significant genetic risk factors for exfoliation syndrome (XFS) and the related secondary glaucoma (XFG). A rare LOXL1 missense allele has been associated with protective effects in a Japa…
View article: Investigation of Known Genetic Risk Factors for Primary Open Angle Glaucoma in Two Populations of African Ancestry
Investigation of Known Genetic Risk Factors for Primary Open Angle Glaucoma in Two Populations of African Ancestry Open
Multiple genes have been associated with primary open angle glaucoma (POAG) in Caucasian populations. We now examine the association of these loci in populations of African ancestry, populations at particularly high risk for POAG.
View article: Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries Open
Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide association studies on a total of 34,179 cases and 349,321 control…
View article: Peripapillary Perfused Capillary Density in Acute Angle-Closure Glaucoma: An Optical Coherence Tomography Angiography Study
Peripapillary Perfused Capillary Density in Acute Angle-Closure Glaucoma: An Optical Coherence Tomography Angiography Study Open
The degree of microvascular attenuation in AAC eyes was not different from that in POAG eyes.
View article: Early-onset Exfoliation Syndrome: A Literature Synthesis
Early-onset Exfoliation Syndrome: A Literature Synthesis Open
Precis: We conducted a literature review of younger patients with exfoliation syndrome (XFS) in an attempt to identify case similarities and better understand disease etiology. Purpose: XFS that predisposes to secondary glaucoma is a stron…
View article: Automated Evaluation of Parapapillary Choroidal Microvasculature in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma
Automated Evaluation of Parapapillary Choroidal Microvasculature in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma Open
A progressive decrease in outer PPCMv from the control group to those with PXS without glaucoma to those with PXS and glaucoma (PXG) showed deep peripapillary vasculopathy in pseudoexfoliation syndrome. Choroidal vessel density may be affe…
View article: High-Resolution Ocular Imaging: Combining Advanced Optics and Microtechnology
High-Resolution Ocular Imaging: Combining Advanced Optics and Microtechnology Open
Recent developments in imaging technologies offer great potential for the assessment of retinal ganglion cell disorders, with particular relevance to glaucoma. In particular, advances in this field have allowed unprecedented in vivo access…
View article: Reasons why OCT Global Circumpapillary Retinal Nerve Fiber Layer Thickness is a Poor Measure of Glaucomatous Progression
Reasons why OCT Global Circumpapillary Retinal Nerve Fiber Layer Thickness is a Poor Measure of Glaucomatous Progression Open
Local defects and segmentation errors are easily identified by viewing OCT circumpapillary images, which should be part of the standard protocol for detecting glaucomatous progression.
View article: CLINICAL PROFILES OF GLAUCOMATOUS PATIENTS WITH HIGH- AND LOW-TENSION OPTIC DISC HEMORRHAGES: A COMPARATIVE STUDY
CLINICAL PROFILES OF GLAUCOMATOUS PATIENTS WITH HIGH- AND LOW-TENSION OPTIC DISC HEMORRHAGES: A COMPARATIVE STUDY Open
Background/Aims Optic disc hemorrhage (DH) is an important glaucoma risk factor, and occurs in a wide intraocular pressure (IOP) range. We sought to characterize distinct clinical subtypes of patients with high- (HTDH) and low-tension DHs …
View article: Optical coherence tomography angiography in glaucoma
Optical coherence tomography angiography in glaucoma Open
Assessment of the vasculature within the optic nerve, peripapillary superficial retina, macula, and peripapillary choroid can be determined in glaucoma using optical coherence tomography angiography (OCTA). Decreased perfusion within the p…
View article: Optical Coherence Tomography Can Be Used to Assess Glaucomatous Optic Nerve Damage in Most Eyes With High Myopia
Optical Coherence Tomography Can Be Used to Assess Glaucomatous Optic Nerve Damage in Most Eyes With High Myopia Open
Precis: It is generally assumed that optical coherence tomography (OCT) cannot be used to diagnose glaucomatous optic neuropathy (GON) in high myopes. However, this study presents evidence that there is sufficient information in OCT scans …
View article: Plateau iris syndrome and angle-closure glaucoma in a patient with nail-patella syndrome
Plateau iris syndrome and angle-closure glaucoma in a patient with nail-patella syndrome Open
NPS has been associated with ocular hypertension (OHTN) and open-angle glaucoma (OAG); however, to our knowledge, no association between NPS and angle-closure has previously been reported. The case described here, of a patient with a rare …
View article: Local Glaucomatous Defects of the Circumpapillary Retinal Nerve Fiber Layer Show a Variety of Patterns of Progression
Local Glaucomatous Defects of the Circumpapillary Retinal Nerve Fiber Layer Show a Variety of Patterns of Progression Open
Precis: The region of glaucomatous progression, seen on optical coherence tomography (OCT) images of the circumpapillary retinal nerve fiber layer (cRNFL), increases in width and depth in all eyes, but shows a variety of different patterns…