Robert S. Viger
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View article: Brain‐Specific <i>Gata4</i> Downregulation in <i>Greywick</i> Female Mice Models the Metabolic Subtype of Polycystic Ovary Syndrome
Brain‐Specific <i>Gata4</i> Downregulation in <i>Greywick</i> Female Mice Models the Metabolic Subtype of Polycystic Ovary Syndrome Open
Polycystic ovary syndrome (PCOS) is a heterogenous disorder characterized by reproductive and metabolic abnormalities. PCOS etiology remains poorly understood, although the hypothalamus is suspected to play a central role in many cases. Hu…
View article: Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells
Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells Open
Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin rem…
View article: Brain-specific<i>Gata4</i>downregulation in<i>Greywick</i>female mice models the metabolic subtype of polycystic ovary syndrome
Brain-specific<i>Gata4</i>downregulation in<i>Greywick</i>female mice models the metabolic subtype of polycystic ovary syndrome Open
Polycystic ovary syndrome (PCOS) is a heterogenous disorder characterized by reproductive and metabolic abnormalities. PCOS etiology remains poorly understood, although the hypothalamus is suspected to play a central role in many cases. Hu…
View article: ERK5 Cooperates With MEF2C to Regulate <i>Nr4a1</i> Transcription in MA-10 and MLTC-1 Leydig Cells
ERK5 Cooperates With MEF2C to Regulate <i>Nr4a1</i> Transcription in MA-10 and MLTC-1 Leydig Cells Open
Leydig cells produce hormones required for the development and maintenance of sex characteristics and fertility in males. MEF2 transcription factors are important regulators of Leydig cell gene expression and steroidogenesis. ERK5 is an at…
View article: Roles of the cumulus–oocyte transzonal network and the Fragile X protein family in oocyte competence
Roles of the cumulus–oocyte transzonal network and the Fragile X protein family in oocyte competence Open
In brief RNA granules travel through the cumulus cell network of transzonal projections which is associated with oocyte developmental competence, and RNA packaging involves RNA-binding proteins of the Fragile X protein family. Abstract The…
View article: A Short Promoter Region Containing Conserved Regulatory Motifs Is Required for Steroidogenic Acute Regulatory Protein (Star) Gene Expression in the Mouse Testis
A Short Promoter Region Containing Conserved Regulatory Motifs Is Required for Steroidogenic Acute Regulatory Protein (Star) Gene Expression in the Mouse Testis Open
In the testis, Leydig cells produce steroid hormones that are needed to masculinize typical genetic males during fetal development and to initiate and maintain spermatogenesis at puberty and adulthood, respectively. Steroidogenesis is init…
View article: Epitranscriptome marks detection and localization of RNA modifying proteins in mammalian ovarian follicles
Epitranscriptome marks detection and localization of RNA modifying proteins in mammalian ovarian follicles Open
Background Most of the resources that support the early development of the embryo are stored in the oocyte. Clearing of maternal resources and activation of the embryonic genome to produce its own mRNA transcripts marks the maternal-to-emb…
View article: Insights Into the Roles of GATA Factors in Mammalian Testis Development and the Control of Fetal Testis Gene Expression
Insights Into the Roles of GATA Factors in Mammalian Testis Development and the Control of Fetal Testis Gene Expression Open
Defining how genes get turned on and off in a correct spatiotemporal manner is integral to our understanding of the development, differentiation, and function of different cell types in both health and disease. Testis development and subse…
View article: Transcription Factors in the Regulation of Leydig Cell Gene Expression and Function
Transcription Factors in the Regulation of Leydig Cell Gene Expression and Function Open
Cell differentiation and acquisition of specialized functions are inherent steps in events that lead to normal tissue development and function. These processes require accurate temporal, tissue, and cell-specific activation or repression o…
View article: CHARGE syndrome‐associated proteins FAM172A and CHD7 influence male sex determination and differentiation through transcriptional and alternative splicing mechanisms
CHARGE syndrome‐associated proteins FAM172A and CHD7 influence male sex determination and differentiation through transcriptional and alternative splicing mechanisms Open
To gain further insight into chromatin‐mediated regulation of mammalian sex determination, we analyzed the role of the CHARGE syndrome‐associated proteins FAM172A and CHD7. This study is based on our prior discoveries that a subset of corr…
View article: Identification of novel genes and pathways regulated by the orphan nuclear receptor COUP-TFII in mouse MA-10 Leydig cells
Identification of novel genes and pathways regulated by the orphan nuclear receptor COUP-TFII in mouse MA-10 Leydig cells Open
In males, Leydig cells are the main producers of testosterone and insulin-like 3 (INSL3), two hormones essential for sex differentiation and reproductive functions. Chicken ovalbumin upstream promoter-transcription factors I (COUP-TFI/NR2F…
View article: NRF2 DLG Domain Mutations Identified in Japanese Liver Cancer Patients Affect the Transcriptional Activity in HCC Cell Lines
NRF2 DLG Domain Mutations Identified in Japanese Liver Cancer Patients Affect the Transcriptional Activity in HCC Cell Lines Open
Geographically, East Asia had the highest liver cancer burden in 2017. Besides this, liver cancer-related deaths were high in Japan, accounting for 3.90% of total deaths. The development of liver cancer is influenced by several factors, an…
View article: Deletion of the Prdm3 Gene Causes a Neuronal Differentiation Deficiency in P19 Cells
Deletion of the Prdm3 Gene Causes a Neuronal Differentiation Deficiency in P19 Cells Open
PRDM (PRDI-BF1 (positive regulatory domain I-binding factor 1) and RIZ1 (retinoblastoma protein-interacting zinc finger gene 1) homologous domain-containing) transcription factors are a group of proteins that have a significant impact on o…
View article: The Nuclear Receptor COUP-TFII Regulates Amhr2 Gene Transcription via a GC-Rich Promoter Element in Mouse Leydig Cells
The Nuclear Receptor COUP-TFII Regulates Amhr2 Gene Transcription via a GC-Rich Promoter Element in Mouse Leydig Cells Open
The nuclear receptor chicken ovalbumin upstream promoter–transcription factor type II (COUP-TFII)/NR2F2 is expressed in adult Leydig cells, and conditional deletion of the Coup-tfii/Nr2f2 gene impedes their differentiation. Steroid product…
View article: Phosphorylation of <scp>GATA</scp>4 serine 105 but not serine 261 is required for testosterone production in the male mouse
Phosphorylation of <span>GATA</span>4 serine 105 but not serine 261 is required for testosterone production in the male mouse Open
Background GATA 4 is a transcription factor essential for male sex determination, testicular differentiation during fetal development, and male fertility in the adult. GATA 4 exerts part of its function by regulating multiple genes in the …
View article: In Vivo Ablation of the Conserved GATA-Binding Motif in the Amh Promoter Impairs Amh Expression in the Male Mouse
In Vivo Ablation of the Conserved GATA-Binding Motif in the Amh Promoter Impairs Amh Expression in the Male Mouse Open
GATA4 is an essential transcriptional regulator required for gonadal development, differentiation, and function. In the developing testis, proposed GATA4-regulated genes include steroidogenic factor 1 (Nr5a1), SRY-related HMG box 9 (Sox9),…
View article: Notch signaling represses GATA4-induced expression of genes involved in steroid biosynthesis
Notch signaling represses GATA4-induced expression of genes involved in steroid biosynthesis Open
Notch2 and Notch3 and genes of the Notch signaling network are dynamically expressed in developing follicles, where they are essential for granulosa cell proliferation and meiotic maturation. Notch receptors, ligands, and downstream effect…