Robert T. Brooke
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View article: Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging
Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging Open
View article: Epigenetic Age Monitoring in Professional Soccer Players for Tracking Recovery and the Effects of Strenuous Exercise
Epigenetic Age Monitoring in Professional Soccer Players for Tracking Recovery and the Effects of Strenuous Exercise Open
Elite sports have become increasingly professionalized and personalized, with soccer players facing a high number of games per season. This trend presents significant challenges in optimizing training for peak performance and requires rigo…
View article: Estimating Polar Bear (<i>Ursus maritimus</i>) Age Based on an Epigenetic <scp>DNA</scp> Methylation Clock
Estimating Polar Bear (<i>Ursus maritimus</i>) Age Based on an Epigenetic <span>DNA</span> Methylation Clock Open
Knowledge of animal age is essential to wildlife managers for obtaining meaningful and accurate insights into demographic parameters. A common approach to aging wildlife, including bears ( Ursus spp.), has been extracting a tooth during ph…
View article: Pathogenic SIV infection is associated with acceleration of epigenetic age in rhesus macaques
Pathogenic SIV infection is associated with acceleration of epigenetic age in rhesus macaques Open
HIV infection accelerates biological aging, but the contribution of the host's age to this process is unknown. We investigated the influence of SIV infection in macaques (SIVmac) on the risk of comorbidities and aging in young and old rhes…
View article: Human clinical trial of plasmapheresis effects on biomarkers of aging (efficacy and safety trial)
Human clinical trial of plasmapheresis effects on biomarkers of aging (efficacy and safety trial) Open
View article: An exploratory analysis of bezisterim treatment associated with decreased biological age acceleration, and improved clinical measure and biomarker changes in mild-to-moderate probable Alzheimer's disease
An exploratory analysis of bezisterim treatment associated with decreased biological age acceleration, and improved clinical measure and biomarker changes in mild-to-moderate probable Alzheimer's disease Open
Introduction Aging is the primary risk factor for sporadic Alzheimer's disease. Chronic low-grade inflammation associated with aging drives cognitive impairment through multiple mechanisms involving oxidative stress, insulin resistance, an…
View article: DNAm age differences between infinium methylationEPICv1 vs EPICv2 in buffy coat, PBMC, and saliva samples
DNAm age differences between infinium methylationEPICv1 vs EPICv2 in buffy coat, PBMC, and saliva samples Open
This study aims to evaluate differences between Infinium MethylationEPIC (EPICv1) and Infinium MethylationEPICv2 (EPICv2) arrays in estimating DNAm age with eleven DNAm clocks using buffy coat, peripheral blood mononuclear cell (PBMC), and…
View article: At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic (<scp>BI01</scp>) Administration on <scp>DNA</scp> Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle
At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic (<span>BI01</span>) Administration on <span>DNA</span> Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle Open
Senescent cells emerge with aging and injury. The contribution of senescent cells to DNA methylation age (DNAmAGE) in vivo is uncertain. Furthermore, stem cell therapy can mediate “rejuvenation”, but how tissue regeneration controlled by r…
View article: Dietary methionine restriction started late in life promotes healthy aging in a sex-specific manner
Dietary methionine restriction started late in life promotes healthy aging in a sex-specific manner Open
Aging is associated with dysregulated methionine metabolism and increased levels of enzymes in the tyrosine degradation pathway (TDP). To investigate the efficacy of targeting either methionine metabolism or the TDP for healthspan improvem…
View article: A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan
A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan Open
View article: Loss of H3K9 trimethylation leads to premature aging
Loss of H3K9 trimethylation leads to premature aging Open
Aging is the major risk factor for most human diseases and represents a major socio-economical challenge for modern societies. Despite its importance, the process of aging remains poorly understood. Epigenetic dysregulation has been propos…
View article: Epigenetic Age Monitoring in Professional Soccer Players for Tracking Recovery and the Effects of Strenuous Exercise
Epigenetic Age Monitoring in Professional Soccer Players for Tracking Recovery and the Effects of Strenuous Exercise Open
Elite sports have become increasingly professionalized and personalized, with soccer players facing a high number of games per season. This trend presents significant challenges in optimizing training for peak performance and requires rigo…
View article: Dissecting the impact of differentiation stage, replicative history, and cell type composition on epigenetic clocks
Dissecting the impact of differentiation stage, replicative history, and cell type composition on epigenetic clocks Open
View article: Methylome–proteome integration after late‐life voluntary exercise training reveals regulation and target information for improved skeletal muscle health
Methylome–proteome integration after late‐life voluntary exercise training reveals regulation and target information for improved skeletal muscle health Open
Exercise is a potent stimulus for combatting skeletal muscle ageing. To study the effects of exercise on muscle in a preclinical setting, we developed a combined endurance–resistance training stimulus for mice called progressive weighted w…
View article: Loss of H3K9 trimethylation leads to premature aging
Loss of H3K9 trimethylation leads to premature aging Open
SUMMARY Aging is the major risk factor for most human diseases and represents a major socio-economical challenge for modern societies. Despite its importance, the process of aging remains poorly understood. Epigenetic dysregulation has bee…
View article: Cognitive rejuvenation in old rats by hippocampal OSKM gene therapy
Cognitive rejuvenation in old rats by hippocampal OSKM gene therapy Open
View article: A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan
A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan Open
Torpor and hibernation are extreme physiological adaptations of homeotherms associated with pro-longevity effects. Yet the underlying mechanisms of how torpor affects aging, and whether hypothermic and hypometabolic states can be induced t…
View article: Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging
Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging Open
Unlike aged somatic cells, which exhibit a decline in molecular fidelity and eventually reach a state of replicative senescence, pluripotent stem cells can indefinitely replenish themselves while retaining full homeostatic capacity. The co…
View article: Maternal oxytocin treatment at birth increases epigenetic age in male offspring
Maternal oxytocin treatment at birth increases epigenetic age in male offspring Open
Exogenous oxytocin is widely used to induce or augment labor with little understanding of the impact on offspring development. In rodent models, including the prairie vole ( Microtus ochrogaster ), it has been shown that oxytocin administe…
View article: DNA repair‐deficient premature aging models display accelerated epigenetic age
DNA repair‐deficient premature aging models display accelerated epigenetic age Open
Several premature aging mouse models have been developed to study aging and identify interventions that can delay age‐related diseases. Yet, it is still unclear whether these models truly recapitulate natural aging. Here, we analyzed DNA m…
View article: Treatment‐Induced Epigenetic Modifications in MCI and Probable Alzheimer’s Disease
Treatment‐Induced Epigenetic Modifications in MCI and Probable Alzheimer’s Disease Open
Background NE3107 is an oral small molecule, blood‐brain permeable anti‐inflammatory insulin sensitizer that binds ERK, inhibits inflammatory NFkB and TNF signaling in macrophage lineage cells, and in clinical studies for AD (NCT04669028) …
View article: Reversal of biological age in multiple rat organs by young porcine plasma fraction
Reversal of biological age in multiple rat organs by young porcine plasma fraction Open
View article: Author Correction: Universal DNA methylation age across mammalian tissues
Author Correction: Universal DNA methylation age across mammalian tissues Open
View article: DNA methylation networks underlying mammalian traits
DNA methylation networks underlying mammalian traits Open
Using DNA methylation profiles ( n = 15,456) from 348 mammalian species, we constructed phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using unsupervised clustering across all samples, we identified 5…
View article: Universal DNA methylation age across mammalian tissues
Universal DNA methylation age across mammalian tissues Open
View article: Reversal of Biological Age in Multiple Rat Organs by Young Porcine Plasma Fraction
Reversal of Biological Age in Multiple Rat Organs by Young Porcine Plasma Fraction Open
Young blood plasma is known to confer beneficial effects on various organs in mice and rats. However, it was not known whether plasma from young pigs rejuvenates old rat tissues at the epigenetic level; whether it alters the epigenetic clo…
View article: Father’s care uniquely influences male neurodevelopment
Father’s care uniquely influences male neurodevelopment Open
Mammalian infants depend on parental care for survival, with numerous consequences for their behavioral development. We investigated the epigenetic and neurodevelopmental mechanisms mediating the impact of early biparental care on developm…
View article: COGNITIVE REJUVENATION IN OLD RATS BY HIPPOCAMPAL OSKM GENE THERAPY
COGNITIVE REJUVENATION IN OLD RATS BY HIPPOCAMPAL OSKM GENE THERAPY Open
Impaired performance in spatial learning and memory during aging in rats is associated with morphological and molecular changes in the brain, particularly in the hippocampus. Here, we assessed the cognitive performance of young (3.5 mo.) u…
View article: Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging
Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging Open
Unlike aged somatic cells, which exhibit a decline in molecular fidelity and eventually reach a state of replicative senescence, pluripotent stem cells can indefinitely replenish themselves while retaining full homeostatic capacity. The co…
View article: ERCC1 mice, unlike other premature aging models, display accelerated epigenetic age
ERCC1 mice, unlike other premature aging models, display accelerated epigenetic age Open
Over the last decades, several premature aging mouse models have been developed to study aging and identify interventions that can delay age-related diseases. Yet, it is still unclear whether these models truly recapitulate natural aging. …