Robert T. Gampe
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View article: Structural Basis for Androgen Receptor Interdomain and Coactivator Interactions Suggests a Transition in Nuclear Receptor Activation Function Dominance
Structural Basis for Androgen Receptor Interdomain and Coactivator Interactions Suggests a Transition in Nuclear Receptor Activation Function Dominance Open
The androgen receptor (AR) is required for male sex development and contributes to prostate cancer cell survival. In contrast to other nuclear receptors that bind the LXXLL motifs of coactivators, the AR ligand binding domain is preferenti…
View article: Probing the Functional Link between Androgen Receptor Coactivator and Ligand-binding Sites in Prostate Cancer and Androgen Insensitivity
Probing the Functional Link between Androgen Receptor Coactivator and Ligand-binding Sites in Prostate Cancer and Androgen Insensitivity Open
The androgen receptor (AR) is a ligand-activated transcription factor required for male sex development and virilization and contributes to prostate cancer initiation and progression. High affinity androgen binding triggers conformational …
View article: Modulation of Androgen Receptor Activation Function 2 by Testosterone and Dihydrotestosterone
Modulation of Androgen Receptor Activation Function 2 by Testosterone and Dihydrotestosterone Open
The androgen receptor (AR) is transcriptionally activated by high affinity binding of testosterone (T) or its 5α-reduced metabolite, dihydrotestosterone (DHT), a more potent androgen required for male reproductive tract development. The mo…
View article: BacMam production and crystal structure of nonglycosylated apo human furin at 1.89 Å resolution
BacMam production and crystal structure of nonglycosylated apo human furin at 1.89 Å resolution Open
Furin, also called proprotein convertase subtilisin/kexin 3 (PCSK3), is a calcium-dependent serine endoprotease that processes a wide variety of proproteins involved in cell function and homeostasis. Dysregulation of furin has been implica…
View article: Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1
Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1 Open
Bone Morphogenetic Protein 1 (BMP1) inhibition is a potential method for treating fibrosis because BMP1, a member of the zinc metalloprotease family, is required to convert pro-collagen to collagen. A novel class of reverse hydroxamate BMP…