Robert T. Mankowski
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View article: Macrophages Polarization as a Potential Driver and a Therapeutic Target for Sepsis-induced Cognitive Impairment in Older Adults
Macrophages Polarization as a Potential Driver and a Therapeutic Target for Sepsis-induced Cognitive Impairment in Older Adults Open
Sepsis, a dysregulated host response to infection, remains a growing global health concern, particularly in older adults. While much attention focuses on acute survival, an increasing number of sepsis survivors experience persistent neurol…
View article: Home-Based, Remotely-Delivered Exercise Training to Improve Physical Function of Middle-aged and Older Sepsis Survivors – the HEAL Sepsis Trial (Preprint)
Home-Based, Remotely-Delivered Exercise Training to Improve Physical Function of Middle-aged and Older Sepsis Survivors – the HEAL Sepsis Trial (Preprint) Open
BACKGROUND Sepsis survivors frequently experience post-discharge physical function decline and encounter logistical barriers to participation in traditional outpatient rehabilitation. OBJECTIVE This pilot study examined the feasibility,…
View article: Nicotinamide riboside combined with exercise to treat hypertension in middle-aged and older adults: a pilot randomized clinical trial
Nicotinamide riboside combined with exercise to treat hypertension in middle-aged and older adults: a pilot randomized clinical trial Open
Aerobic exercise lowers blood pressure (BP) with varying effects in hypertensive adults, potentially due to age-related nicotinamide adenine dinucleotide (NAD) metabolism dysregulation. This pilot randomized clinical trial (RCT) tested the…
View article: The role of adipose tissue in critical illness-induced skeletal muscle wasting—new considerations for treatment approaches
The role of adipose tissue in critical illness-induced skeletal muscle wasting—new considerations for treatment approaches Open
Critical illness-induced muscle wasting is associated with poor in-hospital and long-term outcomes, but prevention strategies are lacking. Critical illness elicits muscle wasting through upregulation of protein degradation and downregulati…
View article: Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches
Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches Open
Excess cellular senescence contributes to age‐related increases in frailty and reductions in skeletal muscle strength. In the present study, we determined the efficacy of oral intermittent treatment (1 week on—2 weeks off—1 week on) with t…
View article: Intraoperative phrenic nerve stimulation to prevent diaphragm fiber weakness during thoracic surgery
Intraoperative phrenic nerve stimulation to prevent diaphragm fiber weakness during thoracic surgery Open
Thoracic surgery rapidly induces weakness in human diaphragm fibers. The dysfunction is thought to arise from combined effects of the surgical procedures and inactivity. This project tested whether brief bouts of intraoperative hemidiaphra…
View article: Unique gut microbiome signatures associated with physical and cognitive function
Unique gut microbiome signatures associated with physical and cognitive function Open
Background Emerging studies suggest the interaction of the gut microbiome with physical and cognitive function. However, it remains unknown whether the same microbiome is linked with both functions and/or if they are unique. Method Utilizi…
View article: Exercise training to preserve vitality capacity in ageing
Exercise training to preserve vitality capacity in ageing Open
Ageing is an escalating global health issue, with the World Health Organization (WHO) reporting that one in six individuals will be 60 years or older by the year 2030. Therefore, understanding the mechanisms of complex biological ageing pr…
View article: Mitochondrial quality control measures, systemic inflammation, and lower-limb muscle power in older adults: a PROMPT secondary analysis
Mitochondrial quality control measures, systemic inflammation, and lower-limb muscle power in older adults: a PROMPT secondary analysis Open
View article: Home-Based Digital Exercise Training Program to Improve Physical Function of Older Sepsis Survivors: Protocol of the HEAL Sepsis Randomized Clinical Trial
Home-Based Digital Exercise Training Program to Improve Physical Function of Older Sepsis Survivors: Protocol of the HEAL Sepsis Randomized Clinical Trial Open
Background While sepsis, an exaggerated response to infection, can affect people of all age groups, it is more prevalent in middle-aged and older adults. Older adults suffer worse short-term and long-term outcomes than younger patients. Ol…
View article: Iron and cancer: overview of the evidence from population-based studies
Iron and cancer: overview of the evidence from population-based studies Open
Iron is an essential nutrient required for various physiological processes in the body. However, iron imbalance can potentially contribute to initiating and promoting cancer development. Epidemiological studies have investigated the relati…
View article: Iron homeostasis in older adults: balancing nutritional requirements and health risks
Iron homeostasis in older adults: balancing nutritional requirements and health risks Open
Iron plays a crucial role in many physiological processes, including oxygen transport, bioenergetics, and immune function. Iron is assimilated from food and also recycled from senescent red blood cells. Iron exists in two dietary forms: he…
View article: Gut mycobiome dysbiosis after sepsis and trauma
Gut mycobiome dysbiosis after sepsis and trauma Open
Background Sepsis and trauma are known to disrupt gut bacterial microbiome communities, but the impacts and perturbations in the fungal (mycobiome) community after severe infection or injury, particularly in patients experiencing chronic c…
View article: Age Differences in Mobile Technology Use Behavior and Perception During COVID-19
Age Differences in Mobile Technology Use Behavior and Perception During COVID-19 Open
Background and Objectives: COVID-19 led to quarantine and mandatory spatial distancing, making mobile technology critical in receiving information and services. Age differences were discovered in many aspects of mobile technology use; howe…
View article: MoTrPAC Animal Aerobic Exercise Protocol and Biorepository: A Novel Resource for Uncovering Systemic Adaptations to Aerobic Exercise and Extending Healthspan
MoTrPAC Animal Aerobic Exercise Protocol and Biorepository: A Novel Resource for Uncovering Systemic Adaptations to Aerobic Exercise and Extending Healthspan Open
View article: LARGE-SCALE ANALYSIS OF HUMAN GUT MICROBIOTA PATTERNS ACROSS GEOGRAPHY AND PEDIATRIC TO GERIATRIC AGES
LARGE-SCALE ANALYSIS OF HUMAN GUT MICROBIOTA PATTERNS ACROSS GEOGRAPHY AND PEDIATRIC TO GERIATRIC AGES Open
Limited studies to-date have evaluated differences in gut microbiota across a global and temporal scale. Herein, we aim to examine the gut microbiota patterns across geography as defined by continent and countries and how gut microbiota va…
View article: Sex differences in frailty among older adults
Sex differences in frailty among older adults Open
By definition, aging is a natural, gradual and continuous process. On the other hand, frailty reflects the increase in vulnerability to stressors and shortens the time without disease (health span) while longevity refers to the length of l…
View article: Impact of COVID-19 on Mobile Technology use in adults in the United States
Impact of COVID-19 on Mobile Technology use in adults in the United States Open
Background: Mobile technology (MT) has become essential in receiving information and services during the COVID-19 pandemic. Imposed quarantines could have led to varying adaptations of MT use. This study explored how COVID-19 impacted beh…
View article: Understanding Post-Sepsis Syndrome: How Can Clinicians Help?
Understanding Post-Sepsis Syndrome: How Can Clinicians Help? Open
Sepsis is a global health challenge, with over 49 million cases annually. Recent medical advancements have increased in-hospital survival rates to approximately 80%, but the escalating incidence of sepsis, owing to an ageing population, ri…
View article: The persistent inflammation, immunosuppression, and catabolism syndrome 10 years later
The persistent inflammation, immunosuppression, and catabolism syndrome 10 years later Open
With the implementation of new intensive care unit (ICU) therapies in the 1970s, multiple organ failure (MOF) emerged as a fulminant inflammatory phenotype leading to early ICU death. Over the ensuing decades, with fundamental advances in …
View article: Erratum to: Effects of Curcumin C3 Complex® on Physical Function in Moderately Functioning Older Adults with Low-Grade Inflammation–A Pilot Trial
Erratum to: Effects of Curcumin C3 Complex® on Physical Function in Moderately Functioning Older Adults with Low-Grade Inflammation–A Pilot Trial Open
View article: Intraoperative Hemi-Diaphragm Electrical Stimulation Demonstrates Attenuated Mitochondrial Function without Change in Oxidative Stress in Cardiothoracic Surgery Patients
Intraoperative Hemi-Diaphragm Electrical Stimulation Demonstrates Attenuated Mitochondrial Function without Change in Oxidative Stress in Cardiothoracic Surgery Patients Open
Mechanical ventilation during cardiothoracic surgery is life-saving but can lead to ventilator-induced diaphragm dysfunction (VIDD) and prolong ventilator weaning and hospital length of stay. Intraoperative phrenic nerve stimulation may pr…
View article: Relationship between Mitochondrial Quality Control Markers, Lower Extremity Tissue Composition, and Physical Performance in Physically Inactive Older Adults
Relationship between Mitochondrial Quality Control Markers, Lower Extremity Tissue Composition, and Physical Performance in Physically Inactive Older Adults Open
Altered mitochondrial quality and function in muscle may be involved in age-related physical function decline. The role played by the autophagy–lysosome system, a major component of mitochondrial quality control (MQC), is incompletely unde…
View article: Low muscle mass is associated with a higher risk of all–cause and cardiovascular disease–specific mortality in cancer survivors
Low muscle mass is associated with a higher risk of all–cause and cardiovascular disease–specific mortality in cancer survivors Open
View article: Intraoperative phrenic stimulation offsets diaphragm fiber weakness during cardiothoracic surgery
Intraoperative phrenic stimulation offsets diaphragm fiber weakness during cardiothoracic surgery Open
Rationale Mechanical ventilation rapidly induces slow and fast fiber contractile dysfunction in the human diaphragm, which could be attenuated by phrenic nerve stimulation. Here, we present data from a controlled trial of intraoperative ph…
View article: Intra-operative hemi-diaphragm electrical stimulation does not change mitochondrial function in cardiothoracic surgery patients
Intra-operative hemi-diaphragm electrical stimulation does not change mitochondrial function in cardiothoracic surgery patients Open
Background Mechanical ventilation during cardiothoracic surgery is life-saving, but leads to ventilator-induced diaphragm dysfunction (VIDD) and prolongs weaning from the ventilator and hospital stay. Intra-operative diaphragm electrical s…
View article: Intra-operative hemi-diaphragm electrical stimulation does not change mitochondrial function in cardiothoracic surgery patients
Intra-operative hemi-diaphragm electrical stimulation does not change mitochondrial function in cardiothoracic surgery patients Open
Background: Mechanical ventilation during cardiothoracic surgery is life-saving, but leads to ventilator-induced diaphragm dysfunction (VIDD) and prolongs weaning from the ventilator and hospital stay. Intra-operative diaphragm electrical …
View article: 195 Older adults show biomarker evidence of PICS after sepsis
195 Older adults show biomarker evidence of PICS after sepsis Open
OBJECTIVES/GOALS: Many older sepsis survivors develop chronic critical illness (CCI) with poor outcomes. Sepsis is caused by a dysregulated immune response and biomarkers reflecting PICS. The purpose was to compare serial PICS biomarkers i…
View article: Older adults show biomarker evidence of PICS after sepsis
Older adults show biomarker evidence of PICS after sepsis Open
Background: Hospital deaths after sepsis have decreased substantially and most young adult survivors rapidly recover (RAP). However, many older survivors develop chronic critical illness (CCI) with poor long-term outcomes. The etiology of …
View article: Vitamin D Supplementation Is Associated with a Reduction in Self-Reported Falls among Older Adults with Previous Fall History — Feasibility Study
Vitamin D Supplementation Is Associated with a Reduction in Self-Reported Falls among Older Adults with Previous Fall History — Feasibility Study Open
Vitamin D supplementation at the currently recommended dose of 800 IU/day increased blood vitamin D levels and reduced frequency of falls in older adults with low vitamin D levels and a recent fall history.