Robert A. Toth
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View article: A clinical grade neurostimulation implant for hierarchical control of physiological activity
A clinical grade neurostimulation implant for hierarchical control of physiological activity Open
Bioelectronic implants for neurostimulation aim to steer disordered neurophysiological processes back towards a healthy state. However, physiology is subject to biological rhythms, including the circadian rhythm and the sleep-wake cycle. T…
View article: Modulation of motor cortical theta and gamma oscillations using phase-targeted, closed-loop optogenetic stimulation of local excitatory and inhibitory neurons
Modulation of motor cortical theta and gamma oscillations using phase-targeted, closed-loop optogenetic stimulation of local excitatory and inhibitory neurons Open
Theta and gamma oscillations are prominent features of cortical local field potentials (LFPs) and stimulation of the motor cortex at these frequencies can enhance motor learning. Phase-targeted closed-loop stimulation could provide a more …
View article: Optimal inter-electrode distances for maximizing single unit yield per electrode in neural recordings
Optimal inter-electrode distances for maximizing single unit yield per electrode in neural recordings Open
State-of-the-art high-density multielectrode arrays enable the recording of simultaneous spiking activity from hundreds of neurons. Although significant efforts have been dedicated to enhancing neural recording devices and developing more …
View article: An Adaptable Phase-Tracking System for Parkinsonian Rest Tremor: Design and In-Clinic Feasibility
An Adaptable Phase-Tracking System for Parkinsonian Rest Tremor: Design and In-Clinic Feasibility Open
This work provides a novel platform for research involving tremor phase tracking, accounting for PD tremor variability, and a foundation for developing personalized, non-invasive tremor management strategies. Clinical and Translational Imp…
View article: Offline hippocampal reactivation during dentate spikes supports flexible memory
Offline hippocampal reactivation during dentate spikes supports flexible memory Open
Stabilizing new memories requires coordinated neuronal spiking activity during sleep. Hippocampal sharp-wave ripples (SWRs) in the cornu ammonis (CA) region and dentate spikes (DSs) in the dentate gyrus (DG) are prime candidate network eve…
View article: Organizing the coactivity structure of the hippocampus from robust to flexible memory
Organizing the coactivity structure of the hippocampus from robust to flexible memory Open
New memories are integrated into prior knowledge of the world. But what if consecutive memories exert opposing demands on the host brain network? We report that acquiring a robust (food-context) memory constrains the mouse hippocampus with…
View article: Direct data-driven control with signal temporal logic specifications
Direct data-driven control with signal temporal logic specifications Open
Most control synthesis methods under temporal logic properties require a model of the system, however, identifying such a model can be a challenging task. In this work, we develop a direct data-driven control synthesis method for temporal …
View article: Coordinating brain-distributed network activities in memory resistant to extinction
Coordinating brain-distributed network activities in memory resistant to extinction Open
Certain memories resist extinction to continue invigorating maladaptive actions. The robustness of these memories could depend on their widely distributed implementation across populations of neurons in multiple brain regions. However, how…
View article: Hierarchical encoding of reward, effort and choice across the cortex and basal ganglia during cost-benefit decision making
Hierarchical encoding of reward, effort and choice across the cortex and basal ganglia during cost-benefit decision making Open
Adaptive value-guided decision-making requires weighing up the costs and benefits of pursuing an available opportunity. Though neurons across frontal cortical-basal ganglia circuits have been repeatedly shown to represent decision-related …
View article: Organizing the coactivity structure of the hippocampus from robust to flexible memory
Organizing the coactivity structure of the hippocampus from robust to flexible memory Open
New memories are integrated into prior knowledge of the world. But what if consecutive memories exert opposing demands on the host brain network? We report that acquiring a robust (food-context) memory constrains the hippocampus within a p…
View article: An embedded intracranial seizure monitor for objective outcome measurements and rhythm identification
An embedded intracranial seizure monitor for objective outcome measurements and rhythm identification Open
Providing clinicians with objective outcomes of neuromodulation therapy is a key unmet need, especially in emerging areas such as epilepsy and mood disorders. These diseases have episodic behavior and circadian/multidien rhythm characteris…
View article: The Design of Brainstem Interfaces: Characterisation of Physiological Artefacts and Implications for Closed-loop Algorithms
The Design of Brainstem Interfaces: Characterisation of Physiological Artefacts and Implications for Closed-loop Algorithms Open
Surgical neuromodulation through implantable devices allows for stimulation delivery to subcortical regions, crucial for symptom control in many debilitating neurological conditions. Novel closed-loop algorithms deliver therapy tailor-made…
View article: Regulation of Arousal and Performance of a Healthy Non-Human Primate Using Closed-Loop Central Thalamic Deep Brain Stimulation
Regulation of Arousal and Performance of a Healthy Non-Human Primate Using Closed-Loop Central Thalamic Deep Brain Stimulation Open
Application of closed-loop approaches in systems neuroscience and brain-computer interfaces holds great promise for revolutionizing our understanding of the brain and for developing novel neuromodulation strategies to restore lost function…
View article: The Design of Brainstem Interfaces: Characterisation of Physiological Artefacts and Implications for Closed-loop Algorithms
The Design of Brainstem Interfaces: Characterisation of Physiological Artefacts and Implications for Closed-loop Algorithms Open
Surgical neuromodulation through implantable devices allows for stimulation delivery to subcortical regions, crucial for symptom control in many debilitating neurological conditions. Novel closed-loop algorithms deliver therapy tailor-made…
View article: Computationally efficient neural network classifiers for next generation closed loop neuromodulation therapy - a case study in epilepsy
Computationally efficient neural network classifiers for next generation closed loop neuromodulation therapy - a case study in epilepsy Open
This work explores the potential utility of neural network classifiers for real- time classification of field-potential based biomarkers in next-generation responsive neuromodulation systems. Compared to classical filter-based classifiers,…
View article: Computationally efficient neural network classifiers for next generation closed loop neuromodulation therapy -- a case study in epilepsy
Computationally efficient neural network classifiers for next generation closed loop neuromodulation therapy -- a case study in epilepsy Open
This work explores the potential utility of neural network classifiers for real-time classification of field-potential based biomarkers in next-generation responsive neuromodulation systems. Compared to classical filter-based classifiers, …
View article: DyNeuMo Mk-1: Design and pilot validation of an investigational motion-adaptive neurostimulator with integrated chronotherapy
DyNeuMo Mk-1: Design and pilot validation of an investigational motion-adaptive neurostimulator with integrated chronotherapy Open
There is growing interest in using adaptive neuromodulation to provide a more personalized therapy experience that might improve patient outcomes. Current implant technology, however, can be limited in its adaptive algorithm capability. To…
View article: Case Report: Embedding “Digital Chronotherapy” Into Medical Devices—A Canine Validation for Controlling Status Epilepticus Through Multi-Scale Rhythmic Brain Stimulation
Case Report: Embedding “Digital Chronotherapy” Into Medical Devices—A Canine Validation for Controlling Status Epilepticus Through Multi-Scale Rhythmic Brain Stimulation Open
Circadian and other physiological rhythms play a key role in both normal homeostasis and disease processes. Such is the case of circadian and infradian seizure patterns observed in epilepsy. However, these rhythms are not fully exploited i…
View article: MP46-15 OUTPATIENT TRANS-RECTAL MR-GUIDED LASER FOCAL THERAPY PHASE II CLINICAL TRIAL: 11-YEAR INTERIM RESULTS
MP46-15 OUTPATIENT TRANS-RECTAL MR-GUIDED LASER FOCAL THERAPY PHASE II CLINICAL TRIAL: 11-YEAR INTERIM RESULTS Open
You have accessJournal of UrologyProstate Cancer: Localized: Ablative Therapy (MP46)1 Sep 2021MP46-15 OUTPATIENT TRANS-RECTAL MR-GUIDED LASER FOCAL THERAPY PHASE II CLINICAL TRIAL: 11-YEAR INTERIM RESULTS John Feller, Bernadette Greenwood,…
View article: Do not waste your electrodes—principles of optimal electrode geometry for spike sorting
Do not waste your electrodes—principles of optimal electrode geometry for spike sorting Open
Objective . This study examines how the geometrical arrangement of electrodes influences spike sorting efficiency, and attempts to formalise principles for the design of electrode systems enabling optimal spike sorting performance. Approac…
View article: DyNeuMo Mk-2: An Investigational Circadian-Locked Neuromodulator with Responsive Stimulation for Applied Chronobiology
DyNeuMo Mk-2: An Investigational Circadian-Locked Neuromodulator with Responsive Stimulation for Applied Chronobiology Open
Deep brain stimulation (DBS) for Parkinson's disease, essential tremor and epilepsy is an established palliative treatment. DBS uses electrical neuromodulation to suppress symptoms. Most current systems provide a continuous pattern of fixe…
View article: DyNeuMo Mk-1: Design and Pilot Validation of an Investigational Motion-Adaptive Neurostimulator with Integrated Chronotherapy
DyNeuMo Mk-1: Design and Pilot Validation of an Investigational Motion-Adaptive Neurostimulator with Integrated Chronotherapy Open
There is growing interest in using adaptive neuro-modulation to provide a more personalized therapy experience that might improve patient outcomes. Current implant technology, however, can be limited in its adaptive algorithm capability. T…
View article: Frequency and Phase Synchronization in Distributed (Implantable-Transcutaneous) Neural Interfaces
Frequency and Phase Synchronization in Distributed (Implantable-Transcutaneous) Neural Interfaces Open
Synchronized oscillations are a ubiquitous feature of neuronal circuits and can modulate online information transfer and plasticity between brain areas. The disruption of these oscillatory processes is associated with the symptoms of sever…