Robert Turcotte
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View article: Health Perceptions and HRQL With Soft‐Tissue Sarcoma at 12 Months Post‐Op: Using the Wilson‐Cleary Model to Evaluate the Measurement Properties of the RNLI and EQ‐5D‐3L
Health Perceptions and HRQL With Soft‐Tissue Sarcoma at 12 Months Post‐Op: Using the Wilson‐Cleary Model to Evaluate the Measurement Properties of the RNLI and EQ‐5D‐3L Open
Introduction It is increasingly apparent that the most used patient‐reported outcome measure in health‐related quality of life (HRQL) soft‐tissue sarcoma research ( Toronto Extremity Salvage Score ) is limited by its exclusive focus on phy…
View article: Aberrant EZHIP expression drives tumorigenesis in osteosarcoma
Aberrant EZHIP expression drives tumorigenesis in osteosarcoma Open
Osteosarcomas (OS) are aggressive bone tumors known for their extensive structural variations and rare recurrent oncogenic driver mutations. In this study, we identify ectopic expression of the oncohistone-mimic EZHIP in 20% of patients ac…
View article: An Indole-Rich Postbiotic Reduces Itching in Dogs: A Randomized, Double-Blinded Placebo-Controlled Study
An Indole-Rich Postbiotic Reduces Itching in Dogs: A Randomized, Double-Blinded Placebo-Controlled Study Open
Many dogs suffer from pruritus, which is commonly caused by atopic dermatitis and associated with skin inflammation. The immune system and inflammatory response, and in particular the gut–skin axis, are central to the pathogenesis of atopi…
View article: A Novel Postbiotic Reduces Canine Halitosis
A Novel Postbiotic Reduces Canine Halitosis Open
A majority of dogs suffer from some form of periodontal disease. This frequently manifests as halitosis or oral malodor, caused by microbes underlying poor oral health. Pathogenic oral microbes process dietary or host proteins into volatil…
View article: Real-word experience of pazopanib and sorafenib in patients with desmoid tumors: A CanSaRCC multi-center study
Real-word experience of pazopanib and sorafenib in patients with desmoid tumors: A CanSaRCC multi-center study Open
This retrospective study represents the largest cohort of DT patients treated with sorafenib or pazopanib to date. Discontinuation of treatment in responders is safe. The optimal treatment duration in patients with stable disease remains t…
View article: Patient-physician agreement on function and pain is associated with long-term outcomes in sarcoma: findings from a longitudinal study
Patient-physician agreement on function and pain is associated with long-term outcomes in sarcoma: findings from a longitudinal study Open
Purpose We aimed to describe the level of agreement between patients and physicians on the ratings of daily functioning and pain in a cohort of sarcoma patients and assess how (dis)agreement and its change over time predicted patient-repor…
View article: Uncovering the gaps: A systematic mixed studies review of quality of life measures in extremity soft tissue sarcoma
Uncovering the gaps: A systematic mixed studies review of quality of life measures in extremity soft tissue sarcoma Open
The health‐related quality of life of patients with extremity soft tissue sarcoma (STS) is not precisely captured by current patient‐reported outcome measures. Although functional impairment is central to their concerns, multiple sources o…
View article: Revision Distal Femoral Replacement Using Custom-made Stem and Cone to Augment Proximal Fixation
Revision Distal Femoral Replacement Using Custom-made Stem and Cone to Augment Proximal Fixation Open
Achieving bone fixation during megaprosthesis revision presents a formidable challenge in view of the substantial bone loss. We report treatment of a failed revision distal femoral replacement in an active 36-year-old male mechanic remotel…
View article: Table S3 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Table S3 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Open
Pathway Enrichment Analysis
View article: Table S5 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Table S5 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Open
Golgi Secretome Analysis in Isogenic Lines
View article: Table S6 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Table S6 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Open
Interactions between Stromal and Myeloid compartments
View article: Table S2 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Table S2 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Open
Differential Expression in Isogenic Lines
View article: Data from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Data from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Open
Glycine 34-to-tryptophan (G34W) substitutions in H3.3 arise in approximately 90% of giant cell tumor of bone (GCT). Here, we show H3.3 G34W is necessary for tumor formation. By profiling the epigenome, transcriptome, and secreted proteome …
View article: Supplementary Data from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Supplementary Data from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Open
Supplementary Information
View article: Table S2 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Table S2 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Open
Differential Expression in Isogenic Lines
View article: Supplementary Figures from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Supplementary Figures from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Open
Supplementary Figures
View article: Supplementary Data from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Supplementary Data from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Open
Supplementary Information
View article: Table S1 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Table S1 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Open
Sample Characteristics and Quality Control
View article: Table S1 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Table S1 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Open
Sample Characteristics and Quality Control
View article: Table S3 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Table S3 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Open
Pathway Enrichment Analysis
View article: Table S4 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Table S4 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Open
Cell type-specific markers and pathways in single-cell transcriptomics
View article: Table S6 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Table S6 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Open
Interactions between Stromal and Myeloid compartments
View article: Data from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Data from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Open
Glycine 34-to-tryptophan (G34W) substitutions in H3.3 arise in approximately 90% of giant cell tumor of bone (GCT). Here, we show H3.3 G34W is necessary for tumor formation. By profiling the epigenome, transcriptome, and secreted proteome …
View article: Supplementary Figures from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Supplementary Figures from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Open
Supplementary Figures
View article: Table S4 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Table S4 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Open
Cell type-specific markers and pathways in single-cell transcriptomics
View article: Table S5 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Table S5 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Open
Golgi Secretome Analysis in Isogenic Lines
View article: Appendix A from Treatment Planning and Fracture Prediction in Patients with Skeletal Metastasis with CT-Based Rigidity Analysis
Appendix A from Treatment Planning and Fracture Prediction in Patients with Skeletal Metastasis with CT-Based Rigidity Analysis Open
Appendix A. Calculation of Structural Rigidity
View article: Data from Treatment Planning and Fracture Prediction in Patients with Skeletal Metastasis with CT-Based Rigidity Analysis
Data from Treatment Planning and Fracture Prediction in Patients with Skeletal Metastasis with CT-Based Rigidity Analysis Open
Purpose: Pathologic fractures could be prevented if reliable methods of fracture risk assessment were available. A multicenter prospective study was conducted to identify significant predictors of physicians' treatment plan for skeletal me…
View article: Appendix A from Treatment Planning and Fracture Prediction in Patients with Skeletal Metastasis with CT-Based Rigidity Analysis
Appendix A from Treatment Planning and Fracture Prediction in Patients with Skeletal Metastasis with CT-Based Rigidity Analysis Open
Appendix A. Calculation of Structural Rigidity