Robert Vassallo
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View article: Cardiovascular degeneration in Erdheim-Chester disease: prevalence, burden, and outcomes
Cardiovascular degeneration in Erdheim-Chester disease: prevalence, burden, and outcomes Open
Erdheim-Chester disease (ECD) is a rare systemic histiocytic neoplasm, with cardiac morbidities, including cardiovascular (CV) risk factors and cardiac conditions, playing a significant yet poorly understood role in the disease burden. Thi…
View article: Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae
Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae Open
Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolution and lung repair during severe respira…
View article: Subclassification of Erdheim-Chester Disease: Distinct Clinical and Molecular Findings between Classical and Non-Classical Forms
Subclassification of Erdheim-Chester Disease: Distinct Clinical and Molecular Findings between Classical and Non-Classical Forms Open
Background: Erdheim-Chester disease (ECD) manifests as multi-organ infiltration of clonal histiocytes with mutations primarily in the mitogen-activated protein kinase (MAPK) pathway. The revised classification of histiocytosis (2016) categ…
View article: Blocking <scp>IL</scp>‐23 Signaling Mitigates Cigarette Smoke‐Induced Murine Emphysema
Blocking <span>IL</span>‐23 Signaling Mitigates Cigarette Smoke‐Induced Murine Emphysema Open
Inflammatory cell infiltration is a characteristic feature of COPD and correlates directly with the severity of the disease. Interleukin‐23 (IL‐23) is a pro‐inflammatory cytokine that regulates Th‐17 inflammation, which mediates many patho…
View article: Association between sinusitis and incident rheumatic diseases: a population-based study
Association between sinusitis and incident rheumatic diseases: a population-based study Open
Objectives To determine whether antecedent sinusitis is associated with incident rheumatic disease. Methods This population-based case–control study included all individuals meeting classification criteria for rheumatic diseases between 20…
View article: Comparative single-cell analysis reveals IFN-γ as a driver of respiratory sequelae post COVID-19
Comparative single-cell analysis reveals IFN-γ as a driver of respiratory sequelae post COVID-19 Open
Post-acute sequelae of SARS-CoV-2 infection (PASC) represents an urgent public health challenge, with its impact resonating in over 60 million individuals globally. While a growing body of evidence suggests that dysregulated immune reactio…
View article: Vertical Transmission of SARS-CoV-2–Specific Antibodies and Cytokine Profiles in Pregnancy
Vertical Transmission of SARS-CoV-2–Specific Antibodies and Cytokine Profiles in Pregnancy Open
Despite intensive characterization of immune responses after COVID-19 infection and vaccination, research examining protective correlates of vertical transmission in pregnancy are limited. Herein, we profiled humoral and cellular character…
View article: Long-term outcomes among adults with Langerhans cell histiocytosis
Long-term outcomes among adults with Langerhans cell histiocytosis Open
Advances in the treatment of Langerhans cell histiocytosis (LCH) have resulted in a growing survivor population. There is a lack of data on long-term outcomes among adults with LCH. We conducted a retrospective record review of 219 adults …
View article: <i>BRAF</i> V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis
<i>BRAF</i> V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis Open
In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAFV600E was associated with an increased incidence of second malignancies,…
View article: P1049: CHARACTERISTICS AND OUTCOMES OF CARDIOVASCULAR INVOLVEMENT IN ERDHEIM-CHESTER DISEASE
P1049: CHARACTERISTICS AND OUTCOMES OF CARDIOVASCULAR INVOLVEMENT IN ERDHEIM-CHESTER DISEASE Open
Topic: 16. Myeloproliferative neoplasms - Clinical Background: Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis. Relatively little is known about cardiac involvement in ECD, which occurs in about 40% of cases and h…
View article: Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19
Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19 Open
The relationship between diabetes and coronavirus disease 2019 (COVID-19) is bidirectional: Although individuals with diabetes and high blood glucose (hyperglycemia) are predisposed to severe COVID-19, severe acute respiratory syndrome cor…
View article: Sirolimus as frontline therapy for <i>PTEN</i>-mutated histiocytic sarcoma
Sirolimus as frontline therapy for <i>PTEN</i>-mutated histiocytic sarcoma Open
Not available.
View article: Outcomes After Treatment With Cobimetinib in Patients With Rosai-Dorfman Disease Based on <i>KRAS</i> and <i>MEK</i> Alteration Status
Outcomes After Treatment With Cobimetinib in Patients With Rosai-Dorfman Disease Based on <i>KRAS</i> and <i>MEK</i> Alteration Status Open
Importance Rosai-Dorfman disease (RDD) is a rare histiocytic neoplasm with recent studies showing alterations in the MAPK pathway, most commonly in the KRAS and MEK genes in about 40% of patients. Reports on the use of MEK-inhibitor therap…
View article: Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study
Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study Open
Genentech.
View article: Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination Open
SARS-CoV-2 mRNA vaccination induces robust humoral and cellular immunity in the circulation; however, it is currently unknown whether it elicits effective immune responses in the respiratory tract, particularly against variants of concern …
View article: A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 Study of Safety, Tolerability and Efficacy of Pirfenidone in Patients with Rheumatoid Arthritis Interstitial Lung Disease
A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 Study of Safety, Tolerability and Efficacy of Pirfenidone in Patients with Rheumatoid Arthritis Interstitial Lung Disease Open
Background Interstitial lung disease (ILD) is a known complication of rheumatoid arthritis (RA) with a lifetime risk in any individual of 7.7%. The TRAIL1 trial was a randomized, double-blinded, placebo-controlled, phase 2 study of safety,…
View article: International expert consensus recommendations for the diagnosis and treatment of Langerhans cell histiocytosis in adults
International expert consensus recommendations for the diagnosis and treatment of Langerhans cell histiocytosis in adults Open
Langerhans cell histiocytosis (LCH) can affect children and adults with a wide variety of clinical manifestations, including unifocal, single-system multifocal, single-system pulmonary (smoking-associated), or multisystem disease. The exis…
View article: Mucosal immunity against SARS-CoV-2 variants of concern including Omicron following vaccination
Mucosal immunity against SARS-CoV-2 variants of concern including Omicron following vaccination Open
SARS-CoV-2 mRNA vaccination induces robust humoral and cellular immunity in the circulation; however, it is currently unknown whether it elicits effective immune responses in the respiratory tract, particularly against variants of concern …
View article: Incidence, Risk Factors, and Mortality of Clinical and Subclinical Rheumatoid Arthritis–Associated Interstitial Lung Disease: A Population‐Based Cohort
Incidence, Risk Factors, and Mortality of Clinical and Subclinical Rheumatoid Arthritis–Associated Interstitial Lung Disease: A Population‐Based Cohort Open
Objective To identify the incidence, risk factors, and outcomes of rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) and to assess time trends in the incidence and mortality in RA‐ILD. Methods We included adult residents o…
View article: Sustained, complete response to pexidartinib in a patient with <scp><i>CSF1R</i></scp>‐mutated Erdheim–Chester disease
Sustained, complete response to pexidartinib in a patient with <span><i>CSF1R</i></span>‐mutated Erdheim–Chester disease Open
Erdheim–Chester disease (ECD) is a histiocytic neoplasm that predominantly harbors mitogen‐activated protein kinase (MAPK) pathway variants. MAPK inhibitors typically are effective treatments, but mutations outside the MAPK pathway, such a…
View article: Impact of a Multidisciplinary Tumor Board on the Care of Patients with Histiocytic Disorders: The Histiocytosis Working Group experience
Impact of a Multidisciplinary Tumor Board on the Care of Patients with Histiocytic Disorders: The Histiocytosis Working Group experience Open
Introduction Histiocytic disorders pose significant diagnostic and management challenges for the clinicians due to diverse clinical manifestations and often non-specific histopathologic findings. Herein, we report the tumor board experienc…
View article: Symptoms COVID 19 Positive Vapers Compared to COVID 19 Positive Non-vapers
Symptoms COVID 19 Positive Vapers Compared to COVID 19 Positive Non-vapers Open
Objectives: The purpose of the present study was to assess and describe the severity of symptoms reported by Covid-19 positive patients who vaped (smoked e-cigarettes) when compared to those who did not vape or smoke at the time of the dia…