Robert W. Goodrich
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View article: Dynamic Sickling Assay: A Novel Approach for Assessing RBC Sickling Kinetics in SCD
Dynamic Sickling Assay: A Novel Approach for Assessing RBC Sickling Kinetics in SCD Open
Presentation Date: 6/9/2024 Presentation Start Time: 4:00:00 PM Background Sickle cell anemia has been considered a rare disease for a long time. Recently it has been estimated that the number of cases is constantly increasing and the numb…
View article: Red Blood Cell Deformability and Morphological Dynamic Sickling As a Metric to Monitor Pharmacodynamic Response to Voxelotor
Red Blood Cell Deformability and Morphological Dynamic Sickling As a Metric to Monitor Pharmacodynamic Response to Voxelotor Open
The recent introduction of new therapies, such as hemoglobin (Hb) oxygen affinity modifiers, fetal Hb (HbF) inducers, and gene therapy (replacement of HbS with non-sickling Hb), that affect the Hb polymerization rate for sickle cell diseas…
View article: End-to-end science operations in the era of Extremely Large Telescopes
End-to-end science operations in the era of Extremely Large Telescopes Open
Observatory end-to-end science operations is the overall process starting with a scientific question, represented by a proposal requesting observing time; ending with the analysis of observation data addressing that question; and including…
View article: Maintenance concept for the Extremely Large Telescopes
Maintenance concept for the Extremely Large Telescopes Open
The maintenance concept provides the basis for overall dependability design requirements for Extremely Large Telescopes (ELTs), such as the European Southern Observatory’s ELT, the Thirty Meter Telescope (TMT), and the Giant Magellan Teles…
View article: End-to-end science operations in the era of extremely large telescopes
End-to-end science operations in the era of extremely large telescopes Open
Observatory end-to-end science operations is the overall process starting with a scientific question, represented by a proposal requesting observing time, and ending with the analysis of observation data addressing that question, and inclu…
View article: 1A1: Conflicted Loyalties: Austro-Hungarian Immigrants in Michigan and the Great War
1A1: Conflicted Loyalties: Austro-Hungarian Immigrants in Michigan and the Great War Open
On 1 July 1918, US Army PFC Mario Ruconich of 2nd Division, 23rd Infantry Regiment, Company L was killed by German machine gun fire near the village of Vaux, France. He had volunteered for the US Army in January 1917, mustering at the Colu…
View article: Data and Metadata Management at the Keck Observatory Archive
Data and Metadata Management at the Keck Observatory Archive Open
A collaboration between the W. M. Keck Observatory (WMKO) in Hawaii and the NASA Exoplanet Science Institute (NExScI) in California, the Keck Observatory Archive (KOA) was commissioned in 2004 to archive data from WMKO, which operates two …