Robert W. Sprung
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View article: Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice
Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice Open
Enkephalins are opioid peptides that modulate analgesia, reward, and stress. In vivo detection of enkephalins remains difficult due to transient and low endogenous concentrations and inherent sequence similarity. To begin to address this, …
View article: Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress
Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress Open
Enkephalins are opioid peptides that modulate analgesia, reward, and stress. In vivo detection of enkephalins remains difficult due to transient and low endogenous concentrations and inherent sequence similarity. To begin to address this w…
View article: A signaling inspired synthetic toolkit for efficient production of tyrosine phosphorylated proteins
A signaling inspired synthetic toolkit for efficient production of tyrosine phosphorylated proteins Open
Tyrosine phosphorylation is an important post-translational modification that regulates many biochemical signaling networks in multicellular organisms. To date, 46,000 tyrosines have been observed in human proteins, but relatively little i…
View article: Quantitative proteomic mass spectrometry of protein kinases to determine dynamic heterogeneity of the human kinome
Quantitative proteomic mass spectrometry of protein kinases to determine dynamic heterogeneity of the human kinome Open
The kinome is a dynamic system of kinases regulating signaling networks in cells and dysfunction of protein kinases contributes to many diseases. Regulation of the protein expression of kinases alters cellular responses to environmental ch…
View article: HTLV‐1 infected T cells cause bone loss via small extracellular vesicles
HTLV‐1 infected T cells cause bone loss via small extracellular vesicles Open
Adult T cell leukaemia (ATL), caused by infection with human T‐ lymphotropic virus type 1 (HTLV‐1), is often complicated by hypercalcemia and osteolytic lesions. Therefore, we studied the communication between patient‐derived ATL cells (AT…
View article: Supplementary Data S8 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Data S8 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Supplementary Data S8 Graph Based Cluster Biomarkers
View article: Supplementary Figure S2 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Figure S2 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Supplementary Figure 2. (A) Colony forming ability (progenitor cell content) per equal number of Linlow GFP+ cells in HSPCs transduced with EV,MycWT,MycP59Q, MycT58N. 10,000 GFP+ cells per genotype were plated in M3434 media and enumerated…
View article: Supplementary Figure S7 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Figure S7 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Supplementary Figure 7. (A) UMAP projection of 36085 cells from MycT58N/+ and Myc+/+ mice colored by genotype, as indicated in the legend. (B) UMAP projection of 36085, split by genotype and colored by the combined expression of Mpo (Myelo…
View article: Supplementary Data S4 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Data S4 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Gene Ontology analysis of Cluster 3 genes
View article: Supplementary Methods S1 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Methods S1 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Supplementary Methods
View article: Supplementary Data S3 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Data S3 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Cluster 3 genes
View article: Supplementary Figure S7 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Figure S7 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Supplementary Figure 7. (A) UMAP projection of 36085 cells from MycT58N/+ and Myc+/+ mice colored by genotype, as indicated in the legend. (B) UMAP projection of 36085, split by genotype and colored by the combined expression of Mpo (Myelo…
View article: Supplementary Data S1 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Data S1 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
AML-associated MYC mutations Cosmic
View article: Supplementary Figure S6 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Figure S6 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Supplementary Figure 6. (A-B) Bar graphs of the distribution of white blood cells (WBC) counts (1000/microliter), hemoglobin (Hb, grams/deciliter) and platelets (1000/microliter) in MycT58N/+ and Myc+/+mice at 8 and 12 weeks of age. None o…
View article: Supplementary Data S2 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Data S2 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Differentially expressed genes in single cell RNA sequencing and Enrichr pathway analysis
View article: Supplementary Data S7 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Data S7 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Supplementary Data S7 Proteomic Normalized Spectral Counts
View article: Supplementary Data S6 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Data S6 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Supplementary Data S6 ChIP-seq MACS peaks
View article: Supplementary Figure S2 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Figure S2 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Supplementary Figure 2. (A) Colony forming ability (progenitor cell content) per equal number of Linlow GFP+ cells in HSPCs transduced with EV,MycWT,MycP59Q, MycT58N. 10,000 GFP+ cells per genotype were plated in M3434 media and enumerated…
View article: Supplementary Data S5 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Data S5 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Differentially Expressed Genes in Bulk RNA sequencing
View article: Supplementary Methods S1 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Methods S1 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Supplementary Methods
View article: Data from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Data from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Purpose:Somatic missense mutations in the phosphodegron domain of the MYC gene (MYC Box I or MBI) are detected in the dominant clones of a subset of patients with acute myeloid leukemia (AML), but the mechanisms by which they contribute to…
View article: Supplementary Data S2 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Data S2 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Differentially expressed genes in single cell RNA sequencing and Enrichr pathway analysis
View article: Supplementary Figure S4 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Figure S4 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Supplementary Figure 4. (A) Histogram plot showing the viability (as measured by Acridine Orange/Propidium Iodine stain read on a Cellometer instrument) of control cells, MYCWT, MYCP59Q and MYCT58N expressing cells at before (time 0) and 8…
View article: Supplementary Figure S6 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Figure S6 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Supplementary Figure 6. (A-B) Bar graphs of the distribution of white blood cells (WBC) counts (1000/microliter), hemoglobin (Hb, grams/deciliter) and platelets (1000/microliter) in MycT58N/+ and Myc+/+mice at 8 and 12 weeks of age. None o…
View article: Supplementary Data S1 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Data S1 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
AML-associated MYC mutations Cosmic
View article: Supplementary Figure S1 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Figure S1 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Supplementary Figure 1. Lollipop plots for AML-associated MYC mutations as reported in Ferraro et al.
View article: Supplementary Data S5 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Data S5 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Differentially Expressed Genes in Bulk RNA sequencing
View article: Supplementary Figure S1 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Supplementary Figure S1 from Missense Mutations in <i>Myc Box I</i> Influence Nucleocytoplasmic Transport to Promote Leukemogenesis Open
Supplementary Figure 1. Lollipop plots for AML-associated MYC mutations as reported in Ferraro et al.