Robert R. Wolfe
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View article: Understanding Dietary Protein Quality: Digestible Indispensable Amino Acid Scores and Beyond
Understanding Dietary Protein Quality: Digestible Indispensable Amino Acid Scores and Beyond Open
Dietary protein quality refers to the capacity of a food to meet the human metabolic needs for essential amino acids (EAAs) and nitrogen. This is critical in low- and middle-income countries, where severe protein malnutrition occurs, and r…
View article: Effects of acute essential amino acid intake on post-prandial raw bioimpedance and fluid shifts between healthy young and older adults: An exploratory pilot study
Effects of acute essential amino acid intake on post-prandial raw bioimpedance and fluid shifts between healthy young and older adults: An exploratory pilot study Open
Introduction Age-related anabolic resistance can lead to reduced muscle mass but can be costly and timely to diagnose. Multi-frequency bioelectrical impedance analysis could potentially be used as a non-invasive tool for the assessment of …
View article: Consideration of the role of protein quality in determining dietary protein recommendations
Consideration of the role of protein quality in determining dietary protein recommendations Open
The quality of a dietary protein refers to its ability to provide the EAAs necessary to meet dietary requirements. There are 9 dietary amino acids that cannot be metabolically produced in the body and therefore must be consumed as part of …
View article: Toward a Dynamic Model of Indispensable Amino Acid Requirements of the Adult Human: A Factorial Estimate of Oxidative Amino Acid Losses
Toward a Dynamic Model of Indispensable Amino Acid Requirements of the Adult Human: A Factorial Estimate of Oxidative Amino Acid Losses Open
The use of a factorial model for estimation of minimum IDAA and protein oxidative losses in the adult human provides an essential starting point for an updated understanding of protein and IDAA requirements. Further iterations of the model…
View article: Consuming Whey Protein with Added Essential Amino Acids, Not Carbohydrate, Maintains Postexercise Anabolism While Underfed
Consuming Whey Protein with Added Essential Amino Acids, Not Carbohydrate, Maintains Postexercise Anabolism While Underfed Open
Purpose Energy deficiency decreases muscle protein synthesis (MPS), possibly due to greater whole-body essential amino acid (EAA) requirements and reliance on energy stores. Whether energy deficit–induced anabolic resistance is overcome wi…
View article: Free essential amino acid feeding improves endurance during resistance training via DRP1‐dependent mitochondrial remodelling
Free essential amino acid feeding improves endurance during resistance training via DRP1‐dependent mitochondrial remodelling Open
Background Loss of muscle strength and endurance with aging or in various conditions negatively affects quality of life. Resistance exercise training (RET) is the most powerful means to improve muscle mass and strength, but it does not gen…
View article: Inhibitory regulation of FoxO1 in PPARδ expression drives mitochondria dysfunction and insulin resistance
Inhibitory regulation of FoxO1 in PPARδ expression drives mitochondria dysfunction and insulin resistance Open
Forkhead box protein O1 (FoxO1) regulates muscle growth, but the metabolic role of FoxO1 in skeletal muscle and its mechanisms remain unclear. To explore the metabolic role of FoxO1 in skeletal muscle, we generated skeletal muscle-specific…
View article: Inhibitory regulation of FoxO1 in PPARδ expression drives mitochondria dysfunction and insulin resistance
Inhibitory regulation of FoxO1 in PPARδ expression drives mitochondria dysfunction and insulin resistance Open
Forkhead box protein O1 (FoxO1) regulates muscle growth, but the metabolic role of FoxO1 in skeletal muscle and its mechanisms remain unclear. To explore the metabolic role of FoxO1 in skeletal muscle, we generated skeletal muscle-specific…
View article: Inhibitory regulation of FoxO1 in PPARδ expression drives mitochondria dysfunction and insulin resistance
Inhibitory regulation of FoxO1 in PPARδ expression drives mitochondria dysfunction and insulin resistance Open
Forkhead box protein O1 (FoxO1) regulates muscle growth, but the metabolic role of FoxO1 in skeletal muscle and its mechanisms remain unclear. To explore the metabolic role of FoxO1 in skeletal muscle, we generated skeletal muscle-specific…
View article: 440 Muscle Protein Synthesis and Whole-Body Protein Balance Following Ingestion of Beef or a Soy Protein Based Meat Alternative
440 Muscle Protein Synthesis and Whole-Body Protein Balance Following Ingestion of Beef or a Soy Protein Based Meat Alternative Open
OBJECTIVES/GOALS: We endeavor to investigated the hypothesis that muscle protein synthesis (MPS) is stimulated more after consumption of a 4-ounce beef patty as compared to 4- and 8-ounces of a soy protein based meat alternative (SPBMA) an…
View article: Stimulation of muscle protein synthesis with low-dose amino acid composition in older individuals
Stimulation of muscle protein synthesis with low-dose amino acid composition in older individuals Open
Essential amino acid (EAA)-based compositions have been shown to be effective stimulators of muscle protein synthesis, but the lower limit of effective dosage is not clear. We have used stable isotope tracer methodology to quantify the res…
View article: Metabolic effects of an essential amino acid supplement in adolescents with <scp>PCOS</scp> and obesity
Metabolic effects of an essential amino acid supplement in adolescents with <span>PCOS</span> and obesity Open
Objective Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, insulin resistance, and hepatic steatosis (HS). Because dietary essential amino acid (EAA) supplementation has been shown to decrease HS in various population…
View article: Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome Open
Scope : Dietary proteins and essential amino acids (EAAs) are the major nutritional supplements that support the growth and activity of gut microbes contributing to the wellbeing of their host. This study hypothesizes that daily supplement…
View article: The Importance of Dietary Protein Quality in Mid- to High-Income Countries
The Importance of Dietary Protein Quality in Mid- to High-Income Countries Open
In wealthy countries, the protein intake of adults is usually considered to be adequate, and considerations of protein quality are often deemed irrelevant. The objective was to examine dietary protein intakes of adults in developed countri…
View article: EAAS AND WHEY PROTEIN MAY IMPROVE PHYSICAL FUNCTION OF OLDER ADULTS INDEPENDENTLY OF GUT MICROBIOME
EAAS AND WHEY PROTEIN MAY IMPROVE PHYSICAL FUNCTION OF OLDER ADULTS INDEPENDENTLY OF GUT MICROBIOME Open
Essential amino acids (EAAs) and dietary proteins are major nutritional supplements that support the growth and activity of gut microbes, contributing to the wellbeing of their host. We hypothesized that daily ingestion of EAAs or whey pro…
View article: EVALUATION OF AMINO ACIDS LEVELS OF HOSPITALIZED PATIENTS WITH DELIRIUM
EVALUATION OF AMINO ACIDS LEVELS OF HOSPITALIZED PATIENTS WITH DELIRIUM Open
Delirium is an acute and often fluctuating change in cognitive status characterized by disorientation, disorganized thought processes and changes in perceptual and psychomotor function. The common precipitating etiologies of delirium inclu…
View article: International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance
International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance Open
Position Statement: The International Society of Sports Nutrition (ISSN) presents this position based on a critical examination of literature surrounding the effects of essential amino acid (EAA) supplementation on skeletal muscle maintena…
View article: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults Open
In a recent randomized, double-blind, placebo-controlled trial, we were able to demonstrate the superiority of a dietary supplement composed of essential amino acids (EAAs) over whey protein, in older adults with low physical function. In …
View article: Tracing metabolic flux to assess optimal dietary protein and amino acid consumption
Tracing metabolic flux to assess optimal dietary protein and amino acid consumption Open
There is a general consensus that a dietary protein intake of 0.8 g protein/kg/day will prevent symptoms of protein deficiency in young, healthy individuals. However, individuals in many physiological circumstances may benefit from higher …
View article: Balanced Free Essential Amino Acids and Resistance Exercise Training Synergistically Improve Dexamethasone-Induced Impairments in Muscle Strength, Endurance, and Insulin Sensitivity in Mice
Balanced Free Essential Amino Acids and Resistance Exercise Training Synergistically Improve Dexamethasone-Induced Impairments in Muscle Strength, Endurance, and Insulin Sensitivity in Mice Open
Our previous study shows that an essential amino acid (EAA)-enriched diet attenuates dexamethasone (DEX)-induced declines in muscle mass and strength, as well as insulin sensitivity, but does not affect endurance. In the present study, we …