Robert Zajíček
YOU?
Author Swipe
View article: Dynamic changes of systemic and local myokines in burn patients undergoing physiotherapy: A pilot prospective study
Dynamic changes of systemic and local myokines in burn patients undergoing physiotherapy: A pilot prospective study Open
Myokines, important signalling molecules in regulation of homeostasis in a post-injury state, have not been studied in burn patients. Here, we aimed to analyse dynamic changes in systemic and local concentrations of myokines and evaluated …
View article: Validation of Lipophosphonoxin-loaded Polycaprolactone Nanofiber Dressing for Full-thickness Wounds in a Porcine Model
Validation of Lipophosphonoxin-loaded Polycaprolactone Nanofiber Dressing for Full-thickness Wounds in a Porcine Model Open
The findings underscore the importance of optimizing dressing thickness for effective wound healing. NANO-LPPO dressings exhibit translational potential as a therapeutic option for full-thickness wounds, warranting further preclinical and …
View article: Assessment of Agrimonia eupatoria L. and Lipophosphonoxin (DR-6180) Combination for Wound Repair: Bridging the Gap Between Phytomedicine and Organic Chemistry
Assessment of Agrimonia eupatoria L. and Lipophosphonoxin (DR-6180) Combination for Wound Repair: Bridging the Gap Between Phytomedicine and Organic Chemistry Open
Agrimonia eupatoria L. (AE) has a rich tradition of use in wound healing improvement across various cultures worldwide. In previous studies, we revealed that Agrimonia eupatoria L. water extract (AE) possesses a rich polyphenolic compositi…
View article: Disentangling the Advective Brewer‐Dobson Circulation Change
Disentangling the Advective Brewer‐Dobson Circulation Change Open
Climate models robustly project acceleration of the Brewer‐Dobson circulation (BDC) in response to climate change. However, the BDC trends simulated by comprehensive models are poorly constrained by observations, which cannot even determin…
View article: Current Approaches to Wound Repair in Burns: How far Have we Come From Cover to Close? A Narrative Review
Current Approaches to Wound Repair in Burns: How far Have we Come From Cover to Close? A Narrative Review Open
Burn injuries are a significant global health concern, with more than 11 million people requiring medical intervention each year and approximately 180,000 deaths annually. Despite progress in health and social care, burn injuries continue …
View article: Heterogeneous response to TGF-β1/3 isoforms in fibroblasts of different origins: implications for wound healing and tumorigenesis
Heterogeneous response to TGF-β1/3 isoforms in fibroblasts of different origins: implications for wound healing and tumorigenesis Open
Identification of therapeutic targets for treating fibrotic diseases and cancer remains challenging. Our study aimed to investigate the effects of TGF-β1 and TGF-β3 on myofibroblast differentiation and extracellular matrix deposition in di…
View article: <i>Agrimonia eupatoria</i> L. Aqueous Extract Improves Skin Wound Healing: An <i>In Vitro</i> Study in Fibroblasts and Keratinocytes and <i>In Vivo</i> Study in Rats
<i>Agrimonia eupatoria</i> L. Aqueous Extract Improves Skin Wound Healing: An <i>In Vitro</i> Study in Fibroblasts and Keratinocytes and <i>In Vivo</i> Study in Rats Open
The present data show that AE water extract significantly improves the healing of open and sutured skin wounds. Therefore, our data warrant further testing in animal models that are physiologically and evolutionarily closer to humans.
View article: Novel lipophosphonoxin-loaded polycaprolactone electrospun nanofiber dressing reduces Staphylococcus aureus induced wound infection in mice
Novel lipophosphonoxin-loaded polycaprolactone electrospun nanofiber dressing reduces Staphylococcus aureus induced wound infection in mice Open
Active wound dressings are attracting extensive attention in soft tissue repair and regeneration, including bacteria-infected skin wound healing. As the wide use of antibiotics leads to drug resistance we present here a new concept of woun…
View article: Impact of Antibiotics Associated with the Development of Toxic Epidermal Necrolysis on Early and Late-Onset Infectious Complications
Impact of Antibiotics Associated with the Development of Toxic Epidermal Necrolysis on Early and Late-Onset Infectious Complications Open
Toxic epidermal necrolysis (TEN) is a rare disease, which predominantly manifests as damage to the skin and mucosa. Antibiotics count among the most common triggers of this hypersensitive reaction. Patients with TEN are highly susceptible …
View article: Molecular Changes Underlying Hypertrophic Scarring Following Burns Involve Specific Deregulations at All Wound Healing Stages (Inflammation, Proliferation and Maturation)
Molecular Changes Underlying Hypertrophic Scarring Following Burns Involve Specific Deregulations at All Wound Healing Stages (Inflammation, Proliferation and Maturation) Open
Excessive connective tissue accumulation, a hallmark of hypertrophic scaring, results in progressive deterioration of the structure and function of organs. It can also be seen during tumor growth and other fibroproliferative disorders. The…
View article: Aesculus hippocastanum L. Extract Does Not Induce Fibroblast to Myofibroblast Conversion but Increases Extracellular Matrix Production In Vitro Leading to Increased Wound Tensile Strength in Rats
Aesculus hippocastanum L. Extract Does Not Induce Fibroblast to Myofibroblast Conversion but Increases Extracellular Matrix Production In Vitro Leading to Increased Wound Tensile Strength in Rats Open
The ability of horse chestnut extract (HCE) to induce contraction force in fibroblasts, a process with remarkable significance in skin repair, motivated us to evaluate its wound healing potential in a series of experiments. In the in vitro…
View article: Early Changes during Skin Repair Using Tissue-Engineered Dermal Template in a Full-Thickness Burn
Early Changes during Skin Repair Using Tissue-Engineered Dermal Template in a Full-Thickness Burn Open
Rapid wound closure in extensively burned patients has remained one of the major unresolved issues of medicine. Integra® is the most widely established artificial skin, which is composed of a porous matrix of cross-linked bovine collagen a…
View article: Early surgical management in patients with burns
Early surgical management in patients with burns Open
Burns can be life threatening injuries with a significant risk of lifelong consequences. Severity of thermal injury is assessed using the combination of six essential factors (mechanism of injury, presence of inhalation trauma, extent of t…
View article: The treatment of palmar contact burns in children: a five-year review.
The treatment of palmar contact burns in children: a five-year review. Open
Pediatric palmar contact burns are becoming a common trauma, especially in young children. Treatment of this kind of burn is challenging as well as controversial, regarding the choice between split-thickness or full-thickness skin graft to…
View article: Factors severity of burn injury in childhood
Factors severity of burn injury in childhood Open
Zajištění adekvátní přednemocniční péče dětského pacienta s popáleninovým úrazem je závislé na posouzení šesti základních prognostických faktorů: mechanizmu úrazu, procenta popálené plochy, věku, lokalizace, stupně popálení a anamnestickýc…