Roberta Andrejew
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View article: A Rede Brasileira de Reprodutibilidade
A Rede Brasileira de Reprodutibilidade Open
The movement for open and reproducible science has promoted several changes in the scientific ecosystem. The Brazilian Reproducibility Network (BrRN), created in 2023, seeks to consolidate these efforts at a national level, promoting a col…
View article: Exploring CD39 and CD73 Expression as Potential Biomarkers in Prostate Cancer
Exploring CD39 and CD73 Expression as Potential Biomarkers in Prostate Cancer Open
Prostate cancer (PC) is the most diagnosed tumor in males and ranks as the second leading cause of male mortality in the western world. The CD39 and CD73 enzymes play a crucial role in cancer regulation by degrading nucleotides and forming…
View article: Characterization of Comments About bioRxiv and medRxiv Preprints
Characterization of Comments About bioRxiv and medRxiv Preprints Open
Importance Preprints have been increasingly used in biomedical science, and a key feature of many platforms is public commenting. The content of these comments, however, has not been well studied, and it is unclear whether they resemble th…
View article: Mapping the content of comments on bioRxiv and medRxiv preprints
Mapping the content of comments on bioRxiv and medRxiv preprints Open
Introduction Preprints have been increasingly used in biomedical sciences, providing the opportunity for research to be publicly assessed before journal publication. With the increase in attention over preprints during the COVID-19 pandemi…
View article: Dysfunctional purinergic signaling correlates with disease severity in COVID-19 patients
Dysfunctional purinergic signaling correlates with disease severity in COVID-19 patients Open
Ectonucleotidases modulate inflammatory responses by balancing extracellular ATP and adenosine (ADO) and might be involved in COVID-19 immunopathogenesis. Here, we explored the contribution of extracellular nucleotide metabolism to COVID-1…
View article: The Purinergic System as a Target for the Development of Treatments for Bipolar Disorder
The Purinergic System as a Target for the Development of Treatments for Bipolar Disorder Open
The neurobiological and neurochemical mechanisms underlying the pathophysiology of bipolar disorder are complex and not yet fully understood. From circadian disruption to neuroinflammation, many pathways and signaling molecules are importa…
View article: Role of P2X7 Receptors in Immune Responses During Neurodegeneration
Role of P2X7 Receptors in Immune Responses During Neurodegeneration Open
P2X7 receptors are ion-gated channels activated by ATP. Under pathological conditions, the extensive release of ATP induces sustained P2X7 receptor activation, culminating in induction of proinflammatory pathways with inflammasome assembly…
View article: Antagonistic Roles of P2X7 and P2Y2 Receptors in Neurodegenerative Diseases
Antagonistic Roles of P2X7 and P2Y2 Receptors in Neurodegenerative Diseases Open
OPINION article Front. Pharmacol., 12 April 2021 | https://doi.org/10.3389/fphar.2021.659097
View article: Mesenchymal stem cell‐glioblastoma interactions mediated via kinin receptors unveiled by cytometry
Mesenchymal stem cell‐glioblastoma interactions mediated via kinin receptors unveiled by cytometry Open
Glioblastoma (GBM) is one of the most malignant and devastating brain tumors. The presence of highly therapy‐resistant GBM cell subpopulations within the tumor mass, rapid invasion into brain tissues and reciprocal interactions with stroma…
View article: The P2X7 Receptor: Central Hub of Brain Diseases
The P2X7 Receptor: Central Hub of Brain Diseases Open
The P2X7 receptor is a cation channel activated by high concentrations of adenosine triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming a wide pore that leads to cell death and increased release of AT…
View article: No-Budget Science Hack Week 2020
No-Budget Science Hack Week 2020 Open
Repositório para os projetos desenvolvidos na edição remota da No-Budget Science Hack Week 2020 - https://www.reprodutibilidade.bio.br/hack-week-2020
View article: Effects of N-acetylcysteine on amphetamine-induced sensitization in mice
Effects of N-acetylcysteine on amphetamine-induced sensitization in mice Open
NAC warrants consideration as a candidate for early intervention in ultra-high risk subjects due to its safety profile and the relevance of its mechanism of action. Supplementing this proposition, we report that NAC attenuates sensitizatio…