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View article: Cardiopulmonary determinants of reduced exercise tolerance in Fabry disease
Cardiopulmonary determinants of reduced exercise tolerance in Fabry disease Open
Fabry disease (FD), also known as Anderson-Fabry disease, is a hereditary disorder of glycosphingolipid metabolism, caused by a deficiency of the lysosomal alpha-galactosidase A enzyme. This causes a progressive accumulation of glycosphing…
View article: Fatigue as hallmark of Fabry disease: role of bioenergetic alterations
Fatigue as hallmark of Fabry disease: role of bioenergetic alterations Open
Fabry disease (FD) is a lysosomal storage disorder due to the impaired activity of the α -galactosidase A (GLA) enzyme which induces Gb3 deposition and multiorgan dysfunction. Exercise intolerance and fatigue are frequent and early finding…
View article: Infiltrating macrophages amplify doxorubicin-induced cardiac damage: role of catecholamines
Infiltrating macrophages amplify doxorubicin-induced cardiac damage: role of catecholamines Open
Background The functional contribution of non-myocyte cardiac cells, such as inflammatory cells, in the setup of heart failure in response to doxorubicin (Dox) is recently becoming of growing interest. Objectives The study aims to evaluate…
View article: L-Arginine in diabetes: clinical and preclinical evidence
L-Arginine in diabetes: clinical and preclinical evidence Open
L-Arginine (L-Arg), is a semi-essential amino acid involved in the formation of nitric oxide. The functional relevance of L-Arg in diabetes mellitus has been evaluated both in animal models and in human subjects. In the literature there ar…
View article: miR-4432 Targets FGFBP1 in Human Endothelial Cells
miR-4432 Targets FGFBP1 in Human Endothelial Cells Open
MicroRNAs (miRs) are small non-coding RNAs that modulate the expression of several target genes. Fibroblast growth factor binding protein 1 (FGFBP1) has been associated with endothelial dysfunction at the level of the blood–brain barrier (…
View article: COVID-19 Causes Ferroptosis and Oxidative Stress in Human Endothelial Cells
COVID-19 Causes Ferroptosis and Oxidative Stress in Human Endothelial Cells Open
Oxidative stress and endothelial dysfunction have been shown to play crucial roles in the pathophysiology of COVID-19 (coronavirus disease 2019). On these grounds, we sought to investigate the impact of COVID-19 on lipid peroxidation and f…
View article: Sortilin and hypertension
Sortilin and hypertension Open
Purpose of review The current review aims to present the latest scientific updates on the role of Sortilin in the pathophysiology of hypertension. Recent findings The main focus of this systematic overview is on the functional contribution…
View article: Stress Hyperglycemia Drives the Risk of Hospitalization for Chest Pain in Patients with Ischemia and Non-Obstructive Coronary Arteries (INOCA)
Stress Hyperglycemia Drives the Risk of Hospitalization for Chest Pain in Patients with Ischemia and Non-Obstructive Coronary Arteries (INOCA) Open
OBJECTIVE Ischemia with non-obstructive coronary arteries (INOCA) is a prevailing finding in patients with angina. However, the main factors underlying the risk of being re-hospitalized for chest pain in patients with INOCA remain mostly…
View article: Stress Hyperglycemia Drives the Risk of Hospitalization for Chest Pain in Patients With Ischemia and Nonobstructive Coronary Arteries (INOCA)
Stress Hyperglycemia Drives the Risk of Hospitalization for Chest Pain in Patients With Ischemia and Nonobstructive Coronary Arteries (INOCA) Open
OBJECTIVE Ischemia with nonobstructive coronary arteries (INOCA) is a prevailing finding in patients with angina. However, the main factors underlying the risk of being rehospitalized for chest pain in patients with INOCA remain mostly unk…
View article: Stress Hyperglycemia Drives the Risk of Hospitalization for Chest Pain in Patients with Ischemia and Non-Obstructive Coronary Arteries (INOCA)
Stress Hyperglycemia Drives the Risk of Hospitalization for Chest Pain in Patients with Ischemia and Non-Obstructive Coronary Arteries (INOCA) Open
OBJECTIVE Ischemia with non-obstructive coronary arteries (INOCA) is a prevailing finding in patients with angina. However, the main factors underlying the risk of being re-hospitalized for chest pain in patients with INOCA remain mostly…
View article: Tirzepatide: A Systematic Update
Tirzepatide: A Systematic Update Open
Tirzepatide is a new molecule capable of controlling glucose blood levels by combining the dual agonism of Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide-1 (GLP-1) receptors. GIP and GLP1 are incretin hormones…
View article: Warburg effect characterizes the skeletal muscle in Fabry Disease: experimental evidence and clinical implications
Warburg effect characterizes the skeletal muscle in Fabry Disease: experimental evidence and clinical implications Open
Skeletal muscle (SM) pain and fatigue are common in Fabry disease (FD), and strongly impact the patient’s quality of life. Still, the SM in FD is poorly investigated. Although energetic alterations are reported in cells from FD patients, t…
View article: Warburg effect characterizes the skeletal muscle in Fabry Disease: experimental evidence and clinical implications
Warburg effect characterizes the skeletal muscle in Fabry Disease: experimental evidence and clinical implications Open
Skeletal muscle (SM) pain and fatigue are common in Fabry disease (FD), and strongly impact the patient’s quality of life. Still, the SM in FD is poorly investigated. Although energetic alterations are reported in cells from FD patients, t…
View article: miR-142 Targets TIM-1 in Human Endothelial Cells: Potential Implications for Stroke, COVID-19, Zika, Ebola, Dengue, and Other Viral Infections
miR-142 Targets TIM-1 in Human Endothelial Cells: Potential Implications for Stroke, COVID-19, Zika, Ebola, Dengue, and Other Viral Infections Open
T-cell immunoglobulin and mucin domain 1 (TIM-1) has been recently identified as one of the factors involved in the internalization of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human cells, in addition to angioten…