Roberta Bonafede
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View article: Extracellular vesicles from adipose mesenchymal stem cells target inflamed lymph nodes in experimental autoimmune encephalomyelitis
Extracellular vesicles from adipose mesenchymal stem cells target inflamed lymph nodes in experimental autoimmune encephalomyelitis Open
Background aimsAdipose mesenchymal stem cells (ASCs) represent a promising therapeutic approach in inflammatory neurological disorders, including multiple sclerosis (MS). Recent lines of evidence indicate that most biological activities of…
View article: Data from Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression
Data from Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression Open
Purpose: Human osteosarcoma is a genetically heterogeneous bone malignancy with poor prognosis despite the employment of aggressive chemotherapy regimens. Because druggable driver mutations have not been established, dissecting the interac…
View article: Supplementary material from Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression
Supplementary material from Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression Open
Supplementary figures and legends and supplementary tables
View article: Supplementary material from Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression
Supplementary material from Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression Open
Supplementary figures and legends and supplementary tables
View article: Data from Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression
Data from Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression Open
Purpose: Human osteosarcoma is a genetically heterogeneous bone malignancy with poor prognosis despite the employment of aggressive chemotherapy regimens. Because druggable driver mutations have not been established, dissecting the interac…
View article: Beneficial and Sexually Dimorphic Response to Combined HDAC Inhibitor Valproate and AMPK/SIRT1 Pathway Activator Resveratrol in the Treatment of ALS Mice
Beneficial and Sexually Dimorphic Response to Combined HDAC Inhibitor Valproate and AMPK/SIRT1 Pathway Activator Resveratrol in the Treatment of ALS Mice Open
Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disorder. There is no cure and current treatments fail to slow the progression of the disease. Epigenetic modulation in the acetylation state of NF-kB RelA and th…
View article: ASC-Exosomes Ameliorate the Disease Progression in SOD1(G93A) Murine Model Underlining Their Potential Therapeutic Use in Human ALS
ASC-Exosomes Ameliorate the Disease Progression in SOD1(G93A) Murine Model Underlining Their Potential Therapeutic Use in Human ALS Open
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motoneurons. To date, there is no effective treatment available. Exosomes are extracellular vesicles that play important …
View article: ASCs-Exosomes Recover Coupling Efficiency and Mitochondrial Membrane Potential in an in vitro Model of ALS
ASCs-Exosomes Recover Coupling Efficiency and Mitochondrial Membrane Potential in an in vitro Model of ALS Open
The amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by motoneurons death. Mutations in the superoxide dismutase 1 (SOD1) protein have been identified to be related to the disease. Beyond the differen…
View article: The Anti-Apoptotic Effect of ASC-Exosomes in an In Vitro ALS Model and Their Proteomic Analysis
The Anti-Apoptotic Effect of ASC-Exosomes in an In Vitro ALS Model and Their Proteomic Analysis Open
Stem cell therapy represents a promising approach in the treatment of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). The beneficial effect of stem cells is exerted by paracrine mediators, as exosomes, s…
View article: The role of mutated SOD1 gene in synaptic stripping and MHC class I expression following nerve axotomy in ALS murine model
The role of mutated SOD1 gene in synaptic stripping and MHC class I expression following nerve axotomy in ALS murine model Open
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by motoneuron death. Several cellular pathways have been described to be involved in ALS pathogenesis; however, the involvement of presynaptic str…
View article: Synaptic stripping and MHC class I expression in the facial motor nucleus of ALS mice
Synaptic stripping and MHC class I expression in the facial motor nucleus of ALS mice Open
Pathogenetic mechanisms involved in the fatal, still incurable neurodegenerative disease amyotrophic lateral sclerosis (ALS), characterized by progressive motoneuron death, await full clarification, important for the development of new the…
View article: MRI reveals therapeutical efficacy of stem cells: An experimental study on the SOD1(G93A) animal model
MRI reveals therapeutical efficacy of stem cells: An experimental study on the SOD1(G93A) animal model Open
Purpose The first part of the experiment identifies and validates MRI biomarkers distinctive of the disease progression in the transgenic superoxide dismutase gene (SOD1(G93A)) animal model. The second part assesses the efficacy of a mesen…
View article: Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression
Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression Open
Purpose: Human osteosarcoma is a genetically heterogeneous bone malignancy with poor prognosis despite the employment of aggressive chemotherapy regimens. Because druggable driver mutations have not been established, dissecting the interac…
View article: Magnetic resonance imaging of ultrasmall superparamagnetic iron oxide-labeled exosomes from stem cells: a new method to obtain labeled exosomes
Magnetic resonance imaging of ultrasmall superparamagnetic iron oxide-labeled exosomes from stem cells: a new method to obtain labeled exosomes Open
We report a new approach for labeling of exosomes by USPIO that allows detection by MRI while preserving their morphology and physiological characteristics.