Roberta Meschini
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View article: Monitoring Biochemical Changes of Neuroblastoma Cells in Early Stages After X-Ray Exposure by Using Fourier-Transform Infrared Spectroscopy
Monitoring Biochemical Changes of Neuroblastoma Cells in Early Stages After X-Ray Exposure by Using Fourier-Transform Infrared Spectroscopy Open
X-ray radiation treatments are largely adopted in radiotherapy, and Fourier-transform infrared microspectroscopy (μ-FTIR) has already been demonstrated to be a useful instrument for monitoring radiotherapy effects. Previous works in this f…
View article: Comet assay as an early predictor tool to detect ozone enhanced sensitivity of vegetation in a free-air controlled long-term exposure
Comet assay as an early predictor tool to detect ozone enhanced sensitivity of vegetation in a free-air controlled long-term exposure Open
Although ozone (O3) is a strong oxidant with serious impacts on plants, few studies have investigated the effects on DNA damage. Here we tested the Comet assay combined with the enzymatic isolation of leaf protoplasts. Two species differin…
View article: Plastic additive di(2-ethylhexyl)phthalate (DEHP) causes cell death and micronucleus induction on a bottlenose dolphin’s (Tursiops truncatus) in vitro-exposed skin cell line
Plastic additive di(2-ethylhexyl)phthalate (DEHP) causes cell death and micronucleus induction on a bottlenose dolphin’s (Tursiops truncatus) in vitro-exposed skin cell line Open
Marine plastic pollution is one of the most concerning worldwide environmental issues, and research is day by day demonstrating its adverse effects on marine ecosystems. Nevertheless, little is still known about the toxic potential on mari…
View article: Young transgenic hMTH1 mice are protected against dietary fat‐induced metabolic stress—implications for enhanced longevity
Young transgenic hMTH1 mice are protected against dietary fat‐induced metabolic stress—implications for enhanced longevity Open
hMTH1 protects against mutation during oxidative stress. It degrades 8‐oxodGTP to exclude potentially mutagenic oxidized guanine from DNA. hMTH1 expression is linked to ageing. Its downregulation in cultured cells accelerates RAS‐induced s…
View article: RENEB Inter-Laboratory comparison 2017: limits and pitfalls of ILCs
RENEB Inter-Laboratory comparison 2017: limits and pitfalls of ILCs Open
Based on our study, it seems relevant to develop tools better adapted to the collection and processing of results produced by the participant laboratories. We are confident that, after an initial harmonization phase reached by the RENEB la…
View article: Synthesis and Evaluation of Artemisinin-Based Hybrid and Dimer Derivatives as Antimelanoma Agents
Synthesis and Evaluation of Artemisinin-Based Hybrid and Dimer Derivatives as Antimelanoma Agents Open
A library of hybrid and dimer compounds based on the natural scaffold of artemisinin was synthesized. These
\nderivatives were obtained by coupling of artemisinin derivatives, artesunate, and dihydroartemisinin with a panel of
\nphytochemi…
View article: Different Approaches to FT-IR Microspectroscopy on X-ray Exposed Human Cells
Different Approaches to FT-IR Microspectroscopy on X-ray Exposed Human Cells Open
Fourier-Transform Infrared microspectroscopy (μFT-IR) has been usefully applied in the analysis of the complex biological processes occurring during X-ray radiation-cell interaction. Different experimental approaches are available for FT-I…
View article: In vitro evaluation of cytotoxic and genotoxic effects of Di(2-ethylhexyl)-phthalate (DEHP) on European sea bass (Dicentrarchus labrax) embryonic cell line
In vitro evaluation of cytotoxic and genotoxic effects of Di(2-ethylhexyl)-phthalate (DEHP) on European sea bass (Dicentrarchus labrax) embryonic cell line Open
This is a preprint (pre-peer reviewed) version of the following final paper: "Chiara Molino, Silvia Filippi, Gerardo Antonio Stoppiello, Roberta Meschini, Dario Angeletti, In vitro evaluation of cytotoxic and genotoxic effects of Di(2-ethy…
View article: Oxidative nucleophilic substitution selectively produces cambinol derivatives with antiproliferative activity on bladder cancer cell lines
Oxidative nucleophilic substitution selectively produces cambinol derivatives with antiproliferative activity on bladder cancer cell lines Open
Methyltrioxorhenium mediated oxidative addition/elimination nucleophilic substitution yielded alkylamino and arylamino cambinol derivatives characterized by anti-proliferative activity against wild-type and p53 mutated MGH-U1 and RT112 bla…
View article: Tyrosinase-Treated Hydroxytyrosol-Enriched Olive Vegetation Waste with Increased Antioxidant Activity Promotes Autophagy and Inhibits the Inflammatory Response in Human THP-1 Monocytes
Tyrosinase-Treated Hydroxytyrosol-Enriched Olive Vegetation Waste with Increased Antioxidant Activity Promotes Autophagy and Inhibits the Inflammatory Response in Human THP-1 Monocytes Open
Treatment of olive vegetation waste with tyrosinase immobilized on multiwalled carbon nanotubes increased the antioxidant activity as a consequence of the conversion of phenols to corresponding catechol derivatives, as evaluated by DPPH, C…
View article: Graphene-Based Raman Spectroscopy for pH Sensing of X-rays Exposed and Unexposed Culture Media and Cells
Graphene-Based Raman Spectroscopy for pH Sensing of X-rays Exposed and Unexposed Culture Media and Cells Open
Graphene provides a unique way of sensing the local pH level of substances on the micrometric scale, with important implications for the monitoring of cellular metabolic activities where proton excretion could occur. Accordingly, an innova…
View article: Laccase-Mediated Enhancement of the Antioxidant Activity of Propolis and Poplar Bud Exudates
Laccase-Mediated Enhancement of the Antioxidant Activity of Propolis and Poplar Bud Exudates Open
The treatment of propolis and poplar bud exudates with laccase from Trametes versicolor and 2,2,6,6-tetramethyl-1-piperidinyloxy free radical increased the antioxidant activity, as evaluated by the 2,2'-diphenyl picrylhydrazyl (DPPH…
View article: Dose assessment intercomparisons within the RENEB network using G<sub>0</sub>-lymphocyte prematurely condensed chromosomes (PCC assay)
Dose assessment intercomparisons within the RENEB network using G<sub>0</sub>-lymphocyte prematurely condensed chromosomes (PCC assay) Open
Dose assessments by RENEB partners using appropriate calibration curves were mostly in good agreement. The PCC assay is quick and reliable for whole- or partial-body triage biodosimetry by scoring excess-fragments or dicentrics in G0<…
View article: RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA)
RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA) Open
In case of a large-scale radiological incident, the pooling of ressources by networks can enhance the rapid classification of individuals in medically relevant treatment groups based on the DCA. The performance of the RENEB network as a wh…
View article: Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation
Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation Open
This work has shown the importance of dosimetry in radiobiology studies and the needs of harmonization, standardization in irradiation and dosimetry practices and educational training for biologists using ionizing radiation.
View article: RENEB – Running the European Network of biological dosimetry and physical retrospective dosimetry
RENEB – Running the European Network of biological dosimetry and physical retrospective dosimetry Open
RENEB is a European Network of biological and physical-retrospective dosimetry, with the capacity and capability to perform large-scale rapid individualized dose estimation. Specialized to handle large numbers of samples, RENEB is able to …
View article: Capabilities of the RENEB network for research and large scale radiological and nuclear emergency situations
Capabilities of the RENEB network for research and large scale radiological and nuclear emergency situations Open
The analysis of RENEB questionnaires allowed a detailed assessment of existing capacity of the RENEB network to respond to nuclear and radiological emergencies. This highlighted the key importance of international cooperation in order to g…
View article: RENEB accident simulation exercise
RENEB accident simulation exercise Open
Each participant received training in both the role of a reference laboratory (activating the network) and of a service laboratory (responding to an activation request). The procedures in the case of radiological event were successfully es…
View article: Isolation of Mesophyll Protoplasts from Mediterranean Woody Plants for the Study of DNA Integrity under Abiotic Stress
Isolation of Mesophyll Protoplasts from Mediterranean Woody Plants for the Study of DNA Integrity under Abiotic Stress Open
Abiotic stresses have considerable negative impact on Mediterranean plant ecosystems and better comprehension of the genetic control of response and adaptation of trees to global changes is urgently needed. The single cell gel electrophore…
View article: Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans – joint RENEB and EURADOS inter-laboratory comparisons
Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans – joint RENEB and EURADOS inter-laboratory comparisons Open
Further work is required before the new methods can be included within the suite of reliable dosimetry methods for use by RENEB partners and others in routine and emergency response scenarios.
View article: Transgenerational inheritance of enhanced susceptibility to radiation-induced medulloblastoma in newborn<i>Ptch1+/−</i>mice after paternal irradiation
Transgenerational inheritance of enhanced susceptibility to radiation-induced medulloblastoma in newborn<i>Ptch1+/−</i>mice after paternal irradiation Open
The hypothesis of transgenerational induction of increased cancer susceptibility after paternal radiation exposure has long been controversial because of inconsistent results and the lack of a mechanistic interpretation. Here, exploiting P…