Roberta Misasi
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View article: Proteostasis network response to environmental chronic stress: linking survival to protein aggregation in a human neuroblastoma cellular model
Proteostasis network response to environmental chronic stress: linking survival to protein aggregation in a human neuroblastoma cellular model Open
Proteins tend to misfold upon stressful events that alter their homeostasis, potentially leading to protein aggregation. A tight regulation of synthesis, folding and degradation, defined as proteostasis network (PN), is required to ensure …
View article: Extracellular Vesicles in the Crosstalk of Autophagy and Apoptosis: A Role for Lipid Rafts
Extracellular Vesicles in the Crosstalk of Autophagy and Apoptosis: A Role for Lipid Rafts Open
Autophagy and apoptosis are two essential mechanisms regulating cell fate. Although distinct, their signaling pathways are closely interconnected through various crosstalk mechanisms. Lipid rafts are described to act as both physical and f…
View article: Neuroglobin regulates autophagy through mTORC1/RAPTOR/ULK-1 pathway in human neuroblastoma cells
Neuroglobin regulates autophagy through mTORC1/RAPTOR/ULK-1 pathway in human neuroblastoma cells Open
Neuroglobin (NGB) is a hexacoordinated hemeprotein mainly expressed in neurons. Following its upregulation and mitochondrial localization, NGB plays a pro-survival role against neuronal stress. Previously, we built a stable NGB-FLAG-overex…
View article: Wnt signaling as a translational target in rheumatoid and psoriatic arthritis
Wnt signaling as a translational target in rheumatoid and psoriatic arthritis Open
This study compares the involvement of Wnt signaling in RA and PsA, suggesting that Wnt signaling may represent a possible mechanism of disease activity. In particular, it indicates that DKK1 levels are correlated with CTX-1, a marker of b…
View article: Antibody profiles in the mosaic of ‘seronegative’ APS syndrome
Antibody profiles in the mosaic of ‘seronegative’ APS syndrome Open
Clinical manifestations, as distinct from thrombotic and obstetric morbidity, were recently included in the update of classification criteria of the antiphospholipid syndrome (APS). However, the existence of several patients with clinical …
View article: Autophagy Promotes Enrichment of Raft Components within Extracellular Vesicles Secreted by Human 2FTGH Cells
Autophagy Promotes Enrichment of Raft Components within Extracellular Vesicles Secreted by Human 2FTGH Cells Open
Autophagy plays a key role in removing protein aggregates and damaged organelles. In addition to its conventional degradative functions, autophagy machinery contributes to the release of cytosolic proteins through an unconventional secreti…
View article: Biological Effects of Small Sized Graphene Oxide Nanosheets on Human Leukocytes
Biological Effects of Small Sized Graphene Oxide Nanosheets on Human Leukocytes Open
Since the discovery of graphene, there has been a wide range of the literature dealing with its versatile structure and easy binding of biomolecules as well as its large loading capacity. In the emerging field of immunotherapy, graphene an…
View article: Role of Lipid Rafts on LRP8 Signaling Triggered by Anti-β2-GPI Antibodies in Endothelial Cells
Role of Lipid Rafts on LRP8 Signaling Triggered by Anti-β2-GPI Antibodies in Endothelial Cells Open
Antiphospholipid antibody syndrome is an autoimmune disease characterized by thrombosis and/or pregnancy morbidity in association with circulating antiphospholipid antibodies, mainly anti-β2 glycoprotein 1 antibodies (anti-β2-GPI antibodie…
View article: The Role of Autophagy as a Trigger of Post-Translational Modifications of Proteins and Extracellular Vesicles in the Pathogenesis of Rheumatoid Arthritis
The Role of Autophagy as a Trigger of Post-Translational Modifications of Proteins and Extracellular Vesicles in the Pathogenesis of Rheumatoid Arthritis Open
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease, characterized by persistent joint inflammation, leading to cartilage and bone destruction. Autoantibody production is directed to post-translational modified (PTM) protein…
View article: Role of a Novel Heparanase Inhibitor on the Balance between Apoptosis and Autophagy in U87 Human Glioblastoma Cells
Role of a Novel Heparanase Inhibitor on the Balance between Apoptosis and Autophagy in U87 Human Glioblastoma Cells Open
Background: Heparanase (HPSE) is an endo-β-glucuronidase that cleaves heparan sulfate side chains, leading to the disassembly of the extracellular matrix, facilitating cell invasion and metastasis dissemination. In this research, we invest…
View article: The Importance of Stem Cells Isolated from Human Dental Pulp and Exfoliated Deciduous Teeth as Therapeutic Approach in Nervous System Pathologies
The Importance of Stem Cells Isolated from Human Dental Pulp and Exfoliated Deciduous Teeth as Therapeutic Approach in Nervous System Pathologies Open
Despite decades of research, no therapies are available to halt or slow down the course of neuro-degenerative disorders. Most of the drugs developed to fight neurodegeneration are aimed to alleviate symptoms, but none has proven adequate i…
View article: Antiphospholipid antibodies in patients with stroke during COVID-19: A role in the signaling pathway leading to platelet activation
Antiphospholipid antibodies in patients with stroke during COVID-19: A role in the signaling pathway leading to platelet activation Open
Background Several viral and bacterial infections, including COVID-19, may lead to both thrombotic and hemorrhagic complications. Previously, it has been demonstrated an “ in vitro ” pathogenic effect of “antiphospholipid” antibodies (aPLs…
View article: Advances in the Pathophysiology of Thrombosis in Antiphospholipid Syndrome: Molecular Mechanisms and Signaling through Lipid Rafts
Advances in the Pathophysiology of Thrombosis in Antiphospholipid Syndrome: Molecular Mechanisms and Signaling through Lipid Rafts Open
The pathological features of antiphospholipid syndrome (APS) are related to the activity of circulating antiphospholipid antibodies (aPLs) associated with vascular thrombosis and obstetric complications. Indeed, aPLs are not only disease m…
View article: Editorial for Special Issue: Neuroglobin from Brain Protection to Cancer Progression
Editorial for Special Issue: Neuroglobin from Brain Protection to Cancer Progression Open
Since its discovery in 2000 [...]
View article: Relationship Between Gender Differences and Clinical Outcome in Patients With the Antiphospholipid Syndrome
Relationship Between Gender Differences and Clinical Outcome in Patients With the Antiphospholipid Syndrome Open
Antiphospholipid syndrome (APS), characterized by artherial and/or venous thrombosis, pregnancy morbidity and “antiphospholipid” antibodies (aPLs), is more common in women than in men, with a female to male ratio of about 3.5:1. Only few s…
View article: HMGB1 in Pediatric COVID-19 Infection and MIS-C: A Pilot Study
HMGB1 in Pediatric COVID-19 Infection and MIS-C: A Pilot Study Open
Objective Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, a novel syndrome known as a multisystem inflammatory syndrome in children (MIS-C) was reported in previously healthy children. A possible pro-inflammatory m…
View article: Anti-β2-GPI Antibodies Induce Endothelial Cell Expression of Tissue Factor by LRP6 Signal Transduction Pathway Involving Lipid Rafts
Anti-β2-GPI Antibodies Induce Endothelial Cell Expression of Tissue Factor by LRP6 Signal Transduction Pathway Involving Lipid Rafts Open
In this study we analyzed whether anti-β2-GPI antibodies from patients with APS induce the endothelial cell expression of Tissue Factor (TF) by a LRP6 signal transduction pathway involving lipid rafts. HUVEC were stimulated with affinity p…
View article: Anti-Inflammatory Activity of a CB2 Selective Cannabinoid Receptor Agonist: Signaling and Cytokines Release in Blood Mononuclear Cells
Anti-Inflammatory Activity of a CB2 Selective Cannabinoid Receptor Agonist: Signaling and Cytokines Release in Blood Mononuclear Cells Open
The endocannabinoid system (ECS) exerts immunosuppressive effects, which are mostly mediated by cannabinoid receptor 2 (CBR2), whose expression on leukocytes is higher than CBR1, mainly localized in the brain. Targeted CBR2 activation coul…
View article: Overexpression of Neuroglobin Promotes Energy Metabolism and Autophagy Induction in Human Neuroblastoma SH-SY5Y Cells
Overexpression of Neuroglobin Promotes Energy Metabolism and Autophagy Induction in Human Neuroblastoma SH-SY5Y Cells Open
Neuroglobin (NGB) is an O2-binding globin mainly expressed in the central and peripheral nervous systems and cerebrospinal fluid. Previously, it was demonstrated that NGB overexpression protects cells from hypoxia-induced death. To investi…
View article: Signal transduction pathway involved in platelet activation in immune thrombotic thrombocytopenia after COVID-19 vaccination
Signal transduction pathway involved in platelet activation in immune thrombotic thrombocytopenia after COVID-19 vaccination Open
The severe acute respiratory syndrome-coronarovirus2 (SARS-CoV-2) infection is currently advancing and is exponentially developing the COVID-19 pandemic,1 especially in the USA, Europe, South America, Russia, and India, recording more than…
View article: Role of ERLINs in the Control of Cell Fate through Lipid Rafts
Role of ERLINs in the Control of Cell Fate through Lipid Rafts Open
ER lipid raft-associated protein 1 (ERLIN1) and 2 (ERLIN2) are 40 kDa transmembrane glycoproteins belonging to the family of prohibitins, containing a PHB domain. They are generally localized in the endoplasmic reticulum (ER), where ERLIN1…
View article: Editorial: Targeting Lipid Rafts as a Strategy Against Infection and Cancer
Editorial: Targeting Lipid Rafts as a Strategy Against Infection and Cancer Open
EDITORIAL article Front. Cell Dev. Biol., 06 September 2021 | https://doi.org/10.3389/fcell.2021.748905
View article: Antiphospholipid Antibodies in Patients with Covid-19: Trend Over Time
Antiphospholipid Antibodies in Patients with Covid-19: Trend Over Time Open
Purpose Aim of the study was to investigate whether aPL positivity correlated with thrombosis in COVID-19 patients and whether it was transient or persistent. Methods We enrolled COVID-19 patients who underwent aPL tests: Lupus Anticoagula…
View article: Effect of heparanase inhibitor on tissue factor overexpression in platelets and endothelial cells induced by anti‐β2‐GPI antibodies
Effect of heparanase inhibitor on tissue factor overexpression in platelets and endothelial cells induced by anti‐β2‐GPI antibodies Open
These findings support the view of heparanase involvement in a prothrombotic state related to APS syndrome, suggesting a novel target to regulate overexpression of procoagulant protein(s).
View article: Anti-vimentin/cardiolipin IgA in the anti-phospholipid syndrome: A new tool for ‘seronegative’ diagnosis
Anti-vimentin/cardiolipin IgA in the anti-phospholipid syndrome: A new tool for ‘seronegative’ diagnosis Open
Anti-phospholipid syndrome (APS) is a systemic autoimmune disorder defined by the simultaneous presence of vascular clinical events, pregnancy morbidity and anti-phospholipid antibodies (aPL). In clinical practice, it is possible to find p…
View article: Protein Aggregation Landscape in Neurodegenerative Diseases: Clinical Relevance and Future Applications
Protein Aggregation Landscape in Neurodegenerative Diseases: Clinical Relevance and Future Applications Open
Intrinsic disorder is a natural feature of polypeptide chains, resulting in the lack of a defined three-dimensional structure. Conformational changes in intrinsically disordered regions of a protein lead to unstable β-sheet enriched interm…