Roberto Amici
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View article: Prophylaxis against healthcare-associated infections by non- selective beta-blockers: evidence from large animal experiments and hospital discharge outcomes
Prophylaxis against healthcare-associated infections by non- selective beta-blockers: evidence from large animal experiments and hospital discharge outcomes Open
Healthcare-associated infections (HAIs) pose significant risks, leading to increased morbidity, mortality, and costs, exacerbated by multi-drug-resistant microorganisms. This study aimed to evaluate pharmacological prophylaxis targeting sy…
View article: Fluorescent Neuronal Cells v2: multi-task, multi-format annotations for deep learning in microscopy
Fluorescent Neuronal Cells v2: multi-task, multi-format annotations for deep learning in microscopy Open
Fluorescent Neuronal Cells v2 is a collection of fluorescence microscopy images and the corresponding ground-truth annotations, designed to foster innovative research in the domains of Life Sciences and Deep Learning. This dataset encompas…
View article: Fluorescent Neuronal Cells v2: Multi-Task, Multi-Format Annotations for Deep Learning in Microscopy
Fluorescent Neuronal Cells v2: Multi-Task, Multi-Format Annotations for Deep Learning in Microscopy Open
Fluorescent Neuronal Cells v2 is a collection of fluorescence microscopy images and the corresponding ground-truth annotations, designed to foster innovative research in the domains of Life Sciences and Deep Learning. This dataset encompas…
View article: Corrigendum: Synthetic torpor triggers a regulated mechanism in the rat brain, favoring the reversibility of Tau protein hyperphosphorylation
Corrigendum: Synthetic torpor triggers a regulated mechanism in the rat brain, favoring the reversibility of Tau protein hyperphosphorylation Open
[This corrects the article DOI: 10.3389/fphys.2023.1129278.].
View article: Neurogenic Fever after Subarachnoid Hemorrhage in Animal Models: A Systematic Review
Neurogenic Fever after Subarachnoid Hemorrhage in Animal Models: A Systematic Review Open
The observation of neurogenic fever resulting from subarachnoid hemorrhage (SAH) in animal models is a useful tool for the interpretation of its pathophysiology in humans, which is still a major challenge in the management of neurocritical…
View article: Ultrasonic vocalisations during rapid eye movement sleep in the rat
Ultrasonic vocalisations during rapid eye movement sleep in the rat Open
Summary Rats are known to use a 22‐kHz ultrasonic vocalisation as a distress call to warn of danger to other members of their group. We monitored 22‐kHz ultrasonic vocalisation emissions in rats (lean and obese) as part of a sleep deprivat…
View article: Synthetic torpor triggers a regulated mechanism in the rat brain, favoring the reversibility of Tau protein hyperphosphorylation
Synthetic torpor triggers a regulated mechanism in the rat brain, favoring the reversibility of Tau protein hyperphosphorylation Open
Introduction: Hyperphosphorylated Tau protein (PPTau) is the hallmark of tauopathic neurodegeneration. During “synthetic torpor” (ST), a transient hypothermic state which can be induced in rats by the local pharmacological inhibition of th…
View article: Synthetic torpor triggers a neuroprotective and regulated mechanism in the rat brain, favoring the reversibility of Tau protein hyperphosphorylation
Synthetic torpor triggers a neuroprotective and regulated mechanism in the rat brain, favoring the reversibility of Tau protein hyperphosphorylation Open
Hyperphosphorylated Tau protein (PPTau) is the hallmark of tauopathic neurodegeneration. During “synthetic torpor” (ST), a transient hypothermic state which can be induced in rats by the local pharmacological inhibition of the Raphe Pallid…
View article: Automating cell counting in fluorescent microscopy through deep learning with c-ResUnet
Automating cell counting in fluorescent microscopy through deep learning with c-ResUnet Open
Counting cells in fluorescent microscopy is a tedious, time-consuming task that researchers have to accomplish to assess the effects of different experimental conditions on biological structures of interest. Although such objects are gener…
View article: Reversible Tau Phosphorylation Induced by Synthetic Torpor in the Spinal Cord of the Rat
Reversible Tau Phosphorylation Induced by Synthetic Torpor in the Spinal Cord of the Rat Open
Tau is a key protein in neurons, where it affects the dynamics of the microtubule system. The hyperphosphorylation of Tau (PP-Tau) commonly leads to the formation of neurofibrillary tangles, as it occurs in tauopathies, a group of neurodeg…
View article: Phosphorylated Tau protein in the myenteric plexus of the ileum and colon of normothermic rats and during synthetic torpor
Phosphorylated Tau protein in the myenteric plexus of the ileum and colon of normothermic rats and during synthetic torpor Open
Tau protein is of primary importance for neuronal homeostasis and when hyperphosphorylated (PP-Tau), it tends to aggregate in neurofibrillary tangles, as is the case with tauopathies, a class of neurodegenerative disorders. Reversible PP-T…
View article: Loss of Snord116 alters cortical neuronal activity in mice: a preclinical investigation of Prader–Willi syndrome
Loss of Snord116 alters cortical neuronal activity in mice: a preclinical investigation of Prader–Willi syndrome Open
Prader–Willi syndrome (PWS) is a neurodevelopmental disorder that is characterized by metabolic alteration and sleep abnormalities mostly related to rapid eye movement (REM) sleep disturbances. The disease is caused by genomic imprinting d…
View article: Loss of Snord116 impacts lateral hypothalamus, sleep, and food-related behaviors
Loss of Snord116 impacts lateral hypothalamus, sleep, and food-related behaviors Open
Imprinted genes are highly expressed in the hypothalamus; however, whether specific imprinted genes affect hypothalamic neuromodulators and their functions is unknown. It has been suggested that Prader-Willi syndrome (PWS), a neurodevelopm…
View article: Paternally expressed imprinted<i>Snord116</i>and<i>Peg3</i>regulate hypothalamic orexin neurons
Paternally expressed imprinted<i>Snord116</i>and<i>Peg3</i>regulate hypothalamic orexin neurons Open
Imprinted genes are highly expressed in the hypothalamus; however, whether specific imprinted genes affect hypothalamic neuromodulators and their functions is unknown. It has been suggested that Prader-Willi syndrome (PWS), a neurodevelopm…
View article: Autonomic effects induced by pharmacological activation and inhibition of Raphe Pallidus neurons in anaesthetized adult pigs
Autonomic effects induced by pharmacological activation and inhibition of Raphe Pallidus neurons in anaesthetized adult pigs Open
The Raphe Pallidus (RPa) is a region of the brainstem that was shown to modulate the sympathetic outflow to many tissues and organs involved in thermoregulation and energy expenditure. In rodents, the pharmacological activation of RPa neur…
View article: The paternally imprinted gene<i>Snord116</i>regulates cortical neuronal activity
The paternally imprinted gene<i>Snord116</i>regulates cortical neuronal activity Open
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder that is characterized by rapid eye movement (REM) sleep abnormalities. The disease is caused by genomic imprinting defects that are inherited through the paternal line. Among the…
View article: Phosphorylation and Dephosphorylation of Tau Protein During Synthetic Torpor
Phosphorylation and Dephosphorylation of Tau Protein During Synthetic Torpor Open
Tau protein is of primary importance for many physiological processes in neurons, where it affects the dynamics of the microtubule system. When hyperphosphorylated (PP-Tau), Tau monomers detach from microtubules and tend to aggregate first…
View article: Validation of ‘Somnivore’, a Machine Learning Algorithm for Automated Scoring and Analysis of Polysomnography Data
Validation of ‘Somnivore’, a Machine Learning Algorithm for Automated Scoring and Analysis of Polysomnography Data Open
Manual scoring of polysomnography data is labor-intensive and time-consuming, and most existing software does not account for subjective differences and user variability. Therefore, we evaluated a supervised machine learning algorithm, Som…
View article: Hibernation and Radioprotection: Gene Expression in the Liver and Testicle of Rats Irradiated under Synthetic Torpor
Hibernation and Radioprotection: Gene Expression in the Liver and Testicle of Rats Irradiated under Synthetic Torpor Open
Hibernation has been proposed as a tool for human space travel. In recent years, a procedure to induce a metabolic state known as “synthetic torpor” in non-hibernating mammals was successfully developed. Synthetic torpor may not only be an…
View article: REM Sleep and Endothermy: Potential Sites and Mechanism of a Reciprocal Interference
REM Sleep and Endothermy: Potential Sites and Mechanism of a Reciprocal Interference Open
Numerous data show a reciprocal interaction between REM sleep and thermoregulation. During REM sleep, the function of thermoregulation appears to be impaired; from the other hand, the tonic activation of thermogenesis, such as during cold …
View article: Potential role of the gut microbiota in synthetic torpor and therapeutic hypothermia
Potential role of the gut microbiota in synthetic torpor and therapeutic hypothermia Open
Therapeutic hypothermia is today used in several clinical settings, among them the gut related diseases that are influenced by ischemia/reperfusion injury. This perspective paved the way to the study of hibernation physiology, in natural h…