Roberto B. Sassi
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The stakes of stimulant use, psychosis, and antipsychotic treatment among youth who use drugs: A longitudinal qualitative study Open
Psychosis among youth who use drugs in the context of entrenched poverty is often addressed through aggressive forms of psychiatric intervention. Clinicians must carefully consider the benefits and drawbacks of this approach with this popu…
View article: Outpatient Care Before and After Mental Health Hospitalization for Adolescents From Immigrant, Refugee and Non-immigrant Backgrounds in British Columbia: A Retrospective Cohort Study: Soins en consultation externe avant et après une hospitalisation en santé mentale pour les adolescents, issus ou non de l’immigration ou réfugiés, en Colombie-Britannique: Une étude de cohorte rétrospective
Outpatient Care Before and After Mental Health Hospitalization for Adolescents From Immigrant, Refugee and Non-immigrant Backgrounds in British Columbia: A Retrospective Cohort Study: Soins en consultation externe avant et après une hospitalisation en santé mentale pour les adolescents, issus ou non de l’immigration ou réfugiés, en Colombie-Britannique: Une étude de cohorte rétrospective Open
Objective Understanding differences in outpatient care before and after mental health hospitalization for adolescents from diverse backgrounds is critical to ensuring effective and responsive care. The objective of the current study was to…
Compass—Canada’s first child psychiatry access program: Implementation and lessons learned Open
Background There is a lack of mental health and substance use providers for youth in BC, particularly in rural and remote areas. To address these gaps, Canada’s first child psychiatry access program, BC Children’s Hospital Compass Program,…
View article: Left atrial spatial entropy: a novel tool for electrophysiological substrate characterization in atrial fibrillation
Left atrial spatial entropy: a novel tool for electrophysiological substrate characterization in atrial fibrillation Open
Background Electrical remodeling has been linked to the progression and recurrence of atrial fibrillation (AF) after catheter ablation (CA). Substrate mapping based solely on a voltage amplitude electrogram (EGM) does not provide a compreh…
CCNP innovations in neuropsychopharmacology award: DCC gene network in the prefrontal cortex is associated with total brain volume in childhood Open
Background: Genetic variation in the guidance cue DCC gene is linked to psychopathologies involving dysfunction in the prefrontal cortex. We created an expression-based polygenic risk score (ePRS) based on the DCC coexpression gene network…
View article: Prediction of Emergency Department Revisits among Child and Youth Mental Health Outpatients Using Deep Learning Techniques
Prediction of Emergency Department Revisits among Child and Youth Mental Health Outpatients Using Deep Learning Techniques Open
Background The proportion of Canadian youth seeking mental health support from an emergency department (ED) has risen in recent years. As EDs typically address urgent mental health crises, revisiting an ED may represent unmet mental health…
Serotonin transporter (5-HTT) gene network moderates the impact of prenatal maternal adversity on orbitofrontal cortical thickness in middle childhood Open
In utero, the developing brain is highly susceptible to the environment. For example, adverse maternal experiences during the prenatal period are associated with outcomes such as altered neurodevelopment and emotion dysregulation. Yet, the…
View article: Diagnosis and management of depression in adolescents
Diagnosis and management of depression in adolescents Open
KEY POINTS Depression is common, a leading cause of disability and a major contributor to the overall global burden of disease.[1][1] Although more than 40% of people with depression experience onset before adulthood, depression remains un…
Examining resting-state network connectivity in children exposed to perinatal maternal adversity using anatomically weighted functional connectivity (awFC) analyses; A preliminary report Open
Introduction Environmental perturbations during critical periods can have pervasive, organizational effects on neurodevelopment. To date, the literature examining the long-term impact of early life adversity has largely investigated struct…
Examining attachment, cortisol secretion, and cognitive neurodevelopment in preschoolers and its predictive value for telomere length at age seven Open
Background Secure attachment reflects caregiver-child relationship in which the caregiver is responsive when support and comforting are needed by the child. This pattern of bond has an important buffering role in the response to stress by …
View article: Neuroimaging profiling identifies distinct brain maturational subtypes of youth with mood and anxiety disorders
Neuroimaging profiling identifies distinct brain maturational subtypes of youth with mood and anxiety disorders Open
Mood and anxiety disorders typically begin in adolescence and have overlapping clinical features but marked inter-individual variation in clinical presentation. The use of multimodal neuroimaging data may offer novel insights into the unde…
View article: Cognitive Development and Brain Gray Matter Susceptibility to Prenatal Adversities: Moderation by the Prefrontal Cortex Brain-Derived Neurotrophic Factor Gene Co-expression Network
Cognitive Development and Brain Gray Matter Susceptibility to Prenatal Adversities: Moderation by the Prefrontal Cortex Brain-Derived Neurotrophic Factor Gene Co-expression Network Open
Background: Previous studies focused on the relationship between prenatal conditions and neurodevelopmental outcomes later in life, but few have explored the interplay between gene co-expression networks and prenatal adversity conditions o…
Hypothalamus volume and DNA methylation of stress axis genes in major depressive disorder: A CAN-BIND study report Open
Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis is considered one of the mechanisms underlying the development of major depressive disorder (MDD), but the exact nature of this dysfunction is unknown. We investigated the relati…
LIVES for families psychological first aid training programme to address COVID-19 psychological distress: a mixed methods acceptability and feasibility protocol Open
Introduction Best practice approaches for addressing COVID-19-related psychological distress among young people (<25 years) and their families remain unclear. Psychological first aid (PFA) is promoted by public health authorities to provid…
<i>DCC</i> gene network in the prefrontal cortex is associated with total brain volume in childhood Open
Background Genetic variation in the guidance cue DCC gene is linked to psychopathologies involving dysfunction in the prefrontal cortex. We created an expression-based polygenic risk score (ePRS) based on the DCC coexpression gene network …
Prefrontal gray matter increases in healthy individuals after lithium treatment: A voxel-based morphometry study Open
The objective of this study was to test the hypothesis that 4 weeks of lithium administration would be associated with changes in brain gray and white matter volumes in healthy individuals. Thirteen right-handed healthy volunteers (6 femal…
View article: Expression-based polygenic score from the amygdala 5HTT gene network
Expression-based polygenic score from the amygdala 5HTT gene network Open
This pipeline intends to facilitate the calculation of biologically informed polygenic scores from collected genomic data. This template can be adapted to create other expression-based polygenic risk scores. Data is 1) step by step descrip…
View article: Expression-based polygenic score from the amygdala 5HTT gene network
Expression-based polygenic score from the amygdala 5HTT gene network Open
This pipeline intends to facilitate the calculation of biologically informed polygenic scores from collected genomic data. This template can be adapted to create other expression-based polygenic risk scores. Data is 1) step by step descrip…
View article: Expression-based polygenic score from the amygdala 5HTT gene network
Expression-based polygenic score from the amygdala 5HTT gene network Open
This pipeline intends to facilitate the calculation of biologically informed polygenic scores from collected genomic data. This template can be adapted to create other expression-based polygenic risk scores. Data is 1) step by step descrip…
View article: Expression-based polygenic score from the amygdala 5HTT gene network
Expression-based polygenic score from the amygdala 5HTT gene network Open
This pipeline intends to facilitate the calculation of biologically informed polygenic scores from collected genomic data. This template can be adapted to create other expression-based polygenic risk scores. Data is 1) step by step descrip…
View article: SUN-722 Liver Leptin Receptor Gene Network Moderates the Effects of Early Life Adversity on Anxiety and Depression Problems in Children and Adolescents
SUN-722 Liver Leptin Receptor Gene Network Moderates the Effects of Early Life Adversity on Anxiety and Depression Problems in Children and Adolescents Open
Leptin is a hormone involved in the regulation of food intake, with receptors largely expressed centrally and peripherally, in structures like the hypothalamus and the liver. Beyond its well-known actions as an energy-balance regulator, le…
View article: Amygdala 5-HTT Gene Network Moderates the Effects of Postnatal Adversity on Attention Problems: Anatomo-Functional Correlation and Epigenetic Changes
Amygdala 5-HTT Gene Network Moderates the Effects of Postnatal Adversity on Attention Problems: Anatomo-Functional Correlation and Epigenetic Changes Open
Variations in serotoninergic signaling have been related to behavioral outcomes. Alterations in the genome, such as DNA methylation and histone modifications, are affected by serotonin neurotransmission. The amygdala is an important brain …
An investigation of cortical thickness and antidepressant response in major depressive disorder: A CAN-BIND study report Open
Major depressive disorder (MDD) is considered a highly heterogeneous clinical and neurobiological mental disorder. We employed a novel layered treatment design to investigate whether cortical thickness features at baseline differentiated t…