Roberto Biassoni
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View article: Predictive Microbial Markers Distinguish Responders and Non-Responders to Adalimumab: A Step Toward Precision Medicine in Ulcerative Colitis
Predictive Microbial Markers Distinguish Responders and Non-Responders to Adalimumab: A Step Toward Precision Medicine in Ulcerative Colitis Open
Ulcerative colitis (UC) is a chronic, relapsing inflammatory disease of the colon, often associated with gut microbial dysbiosis. Although anti-TNF-α agents, such as Adalimumab (Cinnora®), are used to treat moderate-to-severe UC, the treat…
View article: In Infants with Neuroblastoma Standard Therapy Only Partially Reverts the Fecal Microbiome Dysbiosis Present at Diagnosis
In Infants with Neuroblastoma Standard Therapy Only Partially Reverts the Fecal Microbiome Dysbiosis Present at Diagnosis Open
The fecal microbiomes of 15 infants with neuroblastoma (NB) at the onset of the disease and after standard-of-care therapy have been prospectively analyzed compared to those of age-matched healthy infants. By applying several algorithms to…
View article: Mucositis and dysbiosis of the oral microbiome and fecal microbial flora in pediatric and young adult patients undergoing allogeneic Hematopoietic Stem Cell Transplantation
Mucositis and dysbiosis of the oral microbiome and fecal microbial flora in pediatric and young adult patients undergoing allogeneic Hematopoietic Stem Cell Transplantation Open
Purpose The oral and gastrointestinal mucosae represent the main targets of the toxic effect of chemo and/or radiotherapy administered as a conditioning regimen before hematopoietic stem cell transplant (HSCT). These harmful consequences a…
View article: Gut-microbiota in children and adolescents with obesity: inferred functional analysis and machine-learning algorithms to classify microorganisms
Gut-microbiota in children and adolescents with obesity: inferred functional analysis and machine-learning algorithms to classify microorganisms Open
The fecal microbiome of 55 obese children and adolescents (BMI-SDS 3.2 ± 0.7) and of 25 normal-weight subjects, matched both for age and sex (BMI-SDS − 0.3 ± 1.1) was analysed. Streptococcus, Acidaminococcus, Sutterella, Prevotella, Sutter…
View article: Gut-microbiota in Obese Children and Adolescents: Inferred Functional Analysis and Machine-learning Algorithms to Classify Microorganisms
Gut-microbiota in Obese Children and Adolescents: Inferred Functional Analysis and Machine-learning Algorithms to Classify Microorganisms Open
The fecal microbiome of 55 obese children and adolescents (BMI-SDS 3.2+/-0.7) and of 25 normal-weight subjects, matched both for age and sex (BMI-SDS -0.3+/-1.1). Streptococcus, Acidaminococcus, Sutterella, Prevotella, Sutterellawadsworthe…
View article: Gut Microbiota Assessment in Obese Children and Adolescents by Machine Learning Algorithms
Gut Microbiota Assessment in Obese Children and Adolescents by Machine Learning Algorithms Open
Gut microbiota has been recently established to play a contributory role in the development and progression of obesity, a multifactorial disease predisposing to several comorbidities. Our aim was to evaluate the gut microbiota composition …
View article: Gut Microbiota in T1DM-Onset Pediatric Patients: Machine-Learning Algorithms to Classify Microorganisms as Disease Linked
Gut Microbiota in T1DM-Onset Pediatric Patients: Machine-Learning Algorithms to Classify Microorganisms as Disease Linked Open
Aims The purpose of this work is to find the gut microbial fingerprinting of pediatric patients with type 1 diabetes. Methods The microbiome of 31 children with type 1 diabetes at onset and of 25 healthy children was determined using multi…
View article: Gut Bacteria and their Metabolites: Which One Is the Defendant for Colorectal Cancer?
Gut Bacteria and their Metabolites: Which One Is the Defendant for Colorectal Cancer? Open
Colorectal cancer (CRC) is a worldwide health concern which requires efficient therapeutic strategies. The mechanisms underlying CRC remain an essential subject of investigations in the cancer biology field. The evaluation of human microbi…
View article: Epidemiology of carbapenemase-producing Enterobacteriaceae in a pediatric hospital in a country with high endemicity
Epidemiology of carbapenemase-producing Enterobacteriaceae in a pediatric hospital in a country with high endemicity Open
In our center metallo-beta lactamases were the most frequently identified carbapenemases in Enterobacteriaceae and E. coli and K. pneumoniae the most frequently isolated pathogens carrying these enzymes. A proactive management strategy was…
View article: Adverse events linked with the use of chimeric and humanized anti‐CD20 antibodies in children with idiopathic nephrotic syndrome
Adverse events linked with the use of chimeric and humanized anti‐CD20 antibodies in children with idiopathic nephrotic syndrome Open
Aims Anti‐CD20 antibodies are increasingly being used to treat idiopathic nephrotic syndrome (INS) in children. While they may allow steroid and calcineurin inhibitor withdrawal, repeated infusions of anti‐CD20 antibodies are often require…
View article: Stability and Expression Levels of HLA-C on the Cell Membrane Modulate HIV-1 Infectivity
Stability and Expression Levels of HLA-C on the Cell Membrane Modulate HIV-1 Infectivity Open
HLA-C expression is associated with a differential ability to control HIV-1 infection. Higher HLA-C levels may lead to better control of HIV-1 infection through both a higher efficiency of antigen presentation to cytotoxic T lymphocytes an…
View article: The whole genome sequencing of Acinetobacter-calcoaceticus-baumannii complex strains involved in suspected outbreak in an Intensive Care Unit of a pediatric hospital
The whole genome sequencing of Acinetobacter-calcoaceticus-baumannii complex strains involved in suspected outbreak in an Intensive Care Unit of a pediatric hospital Open
Background: To analyze the genetic characteristics of Acinetobacter-calcoaceticus-baumannii complex strains isolated in suspected outbreak in a Intensive Care Unit of a pediatric hospital in order to promptly stop the dissemination of this…
View article: <i>TP53</i> codon 72 polymorphism may predict early tumour progression in paediatric pilocytic astrocytoma
<i>TP53</i> codon 72 polymorphism may predict early tumour progression in paediatric pilocytic astrocytoma Open
Pilocytic astrocytoma and ganglioglioma may occur in inaccessible or surgically difficult areas. In case of incomplete resection, the availability of biological predictors of tumour progression could be particularly important. To this end,…