Roberto Chalela
YOU?
Author Swipe
View article: Molecular and immunological features associated with long-term benefits in metastatic NSCLC patients undergoing immune checkpoint blockade
Molecular and immunological features associated with long-term benefits in metastatic NSCLC patients undergoing immune checkpoint blockade Open
Our multimodal analysis of patients with metastatic NSCLC treated with ICB identified clinicopathological and immunological features associated with long-term benefits. The presence of preexisting antitumor immunity emerged as a strong pre…
View article: Stage I and II nonsmall cell lung cancer treatment options
Stage I and II nonsmall cell lung cancer treatment options Open
Chest radiography, computed tomography (CT) and positron emission tomography (PET)-CT are required for staging nonsmall cell lung cancers. Stage I cancers may be up to 4 cm in maximal diameter, with stage IA tumours being up to 3 cm and st…
View article: How will lung cancer screening and lung nodule management change the diagnostic and surgical lung cancer landscape?
How will lung cancer screening and lung nodule management change the diagnostic and surgical lung cancer landscape? Open
Introduction: Implementation of lung cancer screening, with its subsequent findings, is anticipated to change the current diagnostic and surgical lung cancer landscape. This review aimed to identify and present the most updated expert opin…
View article: Chronic Thromboembolic Pulmonary Hypertension after Pulmonary Embolism in SARS-CoV-2
Chronic Thromboembolic Pulmonary Hypertension after Pulmonary Embolism in SARS-CoV-2 Open
Introduction: Chronic thromboembolic pulmonary disease (CTEPD) consists of persistent pulmonary vascular obstruction on imaging and involves long-term functional limitations, with or without chronic thromboembolic pulmonary hypertension (C…
View article: A lung adenocarcinoma patient with ROS1 fusion and NBN germline mutation achieves long progression-free survival from sintilimab combined with niraparib after failure of ROS1 inhibitors: a case report
A lung adenocarcinoma patient with ROS1 fusion and NBN germline mutation achieves long progression-free survival from sintilimab combined with niraparib after failure of ROS1 inhibitors: a case report Open
This case shows that the combination of small-molecule inhibitors and immunotherapy may improve survival in NSCLC patients with driver genes, and sintilimab combined with niraparib provides a successful clinical case for the treatment of r…
View article: EGFR and KRAS Mutations in Lung Parenchyma of Subjects With EGFR/KRAS Wild-Type Lung Adenocarcinoma
EGFR and KRAS Mutations in Lung Parenchyma of Subjects With EGFR/KRAS Wild-Type Lung Adenocarcinoma Open
The acquisition of driver mutations in non-tumoral cells appears to be very important during the carcinogenesis of adenocarcinoma (ADC). Recent studies suggest that cancer-related mutations may not necessarily be present only in malignant …
View article: Case Report on a Patient with Steinert Disease Complicated by COVID-19
Case Report on a Patient with Steinert Disease Complicated by COVID-19 Open
Roberto Chalela, 1– 4 Oswaldo Caguana, 1, 2 Flavio Zuccarino, 5 Karys Khilzi, 1, 2 Diego A Rodríguez-Chiaradía 1– 4 1Respiratory Medicine Department, Hospital del Mar, Barcelona, Spain; 2Institut Hospital del Mar d’Investigacions Mèdiques …
View article: <p>Case Report on Patients with Steinert Disease Complicated by COVID-19</p>
Case Report on Patients with Steinert Disease Complicated by COVID-19 Open
SARS-CoV-2 infection is predominantly a respiratory disease with a diverse clinical spectrum. Pulmonary thromboembolic complications during COVID-19 pneumonia may be associated with a high mortality rate and post-mortem findings confirm th…
View article: Adaptive NKG2C+ natural killer cells are related to exacerbations and nutritional abnormalities in COPD patients
Adaptive NKG2C+ natural killer cells are related to exacerbations and nutritional abnormalities in COPD patients Open
Chronic obstructive pulmonary disease (COPD) is a chronic and often progressive disorder with a heterogeneous presentation and frequent systemic manifestations. Several aspects like persistence in smoking habit, continuous exacerbations, a…
View article: EGFR and KRAS Mutations in the Non-Tumoral Lung. Prognosis in Patients with Adenocarcinoma
EGFR and KRAS Mutations in the Non-Tumoral Lung. Prognosis in Patients with Adenocarcinoma Open
Tumor recurrence is frequent and survival rates remain extremely low in lung adenocarcinoma (ADC). We hypothesize that carcinogenic factors will promote loco-regional modifications not only in the future tumor, but throughout the exposed l…
View article: Molecular analysis of peripheral lung adenocarcinoma in brush cytology obtained by EBUS plus fluoroscopy‐guided bronchoscopy
Molecular analysis of peripheral lung adenocarcinoma in brush cytology obtained by EBUS plus fluoroscopy‐guided bronchoscopy Open
BACKGROUND More than 60% of patients with lung cancer are diagnosed at advanced stages. The introduction of targeted therapies requires molecular diagnosis to guide treatment. The aim of this study was to evaluate the feasibility of perfor…
View article: Issue Information
Issue Information Open
This news section is written by a medical journalist and offers Cancer Cytopathology readers timely information on events, issues, and personalities of interest to the subspecialty.This edition explores the hidden costs of surviving childh…
View article: Bispectral index in hypercapnic encephalopathy associated with COPD exacerbation: a pilot study
Bispectral index in hypercapnic encephalopathy associated with COPD exacerbation: a pilot study Open
BIS may be useful for the objective early detection and automatic monitoring of the intensity of hypercapnic encephalopathy in ECOPD, facilitating the early detection and follow-up of this condition, which may avoid management problems in …
View article: Immune phenotypes in lung cancer patients with COPD: potential implications for immunotherapy
Immune phenotypes in lung cancer patients with COPD: potential implications for immunotherapy Open
Lung cancer remains one of the most commonly diagnosed neoplasms, being responsible for the majority of cancer-related deaths worldwide (1,2). Chronic obstructive pulmonary disease (COPD) is also a major cause of morbidity and mortality gl…
View article: Nutritional status and muscle dysfunction in chronic respiratory diseases: stable phase versus acute exacerbations
Nutritional status and muscle dysfunction in chronic respiratory diseases: stable phase versus acute exacerbations Open
Nutritional abnormalities are frequent in different chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF), interstitial fibrosis and lung cancer, having important clinical c…
View article: Lung adenocarcinoma: from molecular basis to genome-guided therapy and immunotherapy
Lung adenocarcinoma: from molecular basis to genome-guided therapy and immunotherapy Open
Although adenocarcinoma (ADC) is the most frequent lung cancer, its diagnosis is often late, when the local invasion is important and/or the metastases have already appeared. Therefore, the mortality at 5 years is still very high, ranging …