Roberto Coppari
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View article: Nutritional c‐Fos Induction Rewires Hepatic Metabolism and Can Promote Obesity‐Associated Hepatocellular Carcinoma
Nutritional c‐Fos Induction Rewires Hepatic Metabolism and Can Promote Obesity‐Associated Hepatocellular Carcinoma Open
The transcription factor c‐Fos plays a key role in liver metabolism, stress responses, and carcinogenesis. Here, the role of hepatic c‐Fos in the pathophysiology of metabolic dysfunction‐associated steatotic liver disease and hepatocellula…
View article: Harnessing Distinct Tissue-Resident Immune Niches via S100A9/TLR4 Improves Ketone, Lipid, and Glucose Metabolism
Harnessing Distinct Tissue-Resident Immune Niches via S100A9/TLR4 Improves Ketone, Lipid, and Glucose Metabolism Open
The importance of immunometabolism in the development of metabolic diseases is clear. Yet, how certain metabolic disorders, such as insulin deficiency (ID), influence immune cell function, and vice versa, is poorly understood. Also, therap…
View article: Harnessing distinct tissue-resident immune niches <i>via</i> S100A9/TLR4 improves ketone, lipid, and glucose metabolism
Harnessing distinct tissue-resident immune niches <i>via</i> S100A9/TLR4 improves ketone, lipid, and glucose metabolism Open
Immunometabolism contributes to the development of metabolic diseases. Yet, how certain metabolic disorders, such as insulin deficiency (ID), influence immune cell function is poorly understood. Here, we observe that ID rearranges the immu…
View article: Feeding induces c-Fos in hepatocytes contributing to hepatocellular carcinoma in obesity
Feeding induces c-Fos in hepatocytes contributing to hepatocellular carcinoma in obesity Open
The transcription factor c-Fos plays an important role in hepatic metabolism; however, its role in metabolic dysfunction-associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC) is unclear. Here, we show that hepatic c…
View article: S100A9 exerts insulin-independent antidiabetic and anti-inflammatory effects
S100A9 exerts insulin-independent antidiabetic and anti-inflammatory effects Open
Type 1 diabetes mellitus (T1DM) is characterized by insulin deficiency leading to hyperglycemia and several metabolic defects. Insulin therapy remains the cornerstone of T1DM management, yet it increases the risk of life-threatening hypogl…
View article: SIRT6 promotes metastasis and relapse in HER2-positive breast cancer
SIRT6 promotes metastasis and relapse in HER2-positive breast cancer Open
The histone deacetylase sirtuin 6 (SIRT6) has been endowed with anti-cancer capabilities in many tumor types. Here, we investigate the impact of SIRT6-overexpression (SIRT6-OE) in Delta16HER2 mice, which are a bona fide model of HER2-posit…
View article: Supplementary Figure S2 from A Secreted Form of ADAM9 Promotes Carcinoma Invasion through Tumor-Stromal Interactions
Supplementary Figure S2 from A Secreted Form of ADAM9 Promotes Carcinoma Invasion through Tumor-Stromal Interactions Open
Supplementary Figure S2 from A Secreted Form of ADAM9 Promotes Carcinoma Invasion through Tumor-Stromal Interactions
View article: Supplementary Figure S1 from A Secreted Form of ADAM9 Promotes Carcinoma Invasion through Tumor-Stromal Interactions
Supplementary Figure S1 from A Secreted Form of ADAM9 Promotes Carcinoma Invasion through Tumor-Stromal Interactions Open
Supplementary Figure S1 from A Secreted Form of ADAM9 Promotes Carcinoma Invasion through Tumor-Stromal Interactions
View article: Supplementary Figure S2 from A Secreted Form of ADAM9 Promotes Carcinoma Invasion through Tumor-Stromal Interactions
Supplementary Figure S2 from A Secreted Form of ADAM9 Promotes Carcinoma Invasion through Tumor-Stromal Interactions Open
Supplementary Figure S2 from A Secreted Form of ADAM9 Promotes Carcinoma Invasion through Tumor-Stromal Interactions
View article: Data from A Secreted Form of ADAM9 Promotes Carcinoma Invasion through Tumor-Stromal Interactions
Data from A Secreted Form of ADAM9 Promotes Carcinoma Invasion through Tumor-Stromal Interactions Open
Tumor cell invasion is a process regulated by integrins, matrix-degrading enzymes, and interactions with host tissue stromal cells. The ADAM family of proteins plays an important role in modulating various cellular responses. Here, we show…
View article: Supplementary Figure S1 from A Secreted Form of ADAM9 Promotes Carcinoma Invasion through Tumor-Stromal Interactions
Supplementary Figure S1 from A Secreted Form of ADAM9 Promotes Carcinoma Invasion through Tumor-Stromal Interactions Open
Supplementary Figure S1 from A Secreted Form of ADAM9 Promotes Carcinoma Invasion through Tumor-Stromal Interactions
View article: Data from A Secreted Form of ADAM9 Promotes Carcinoma Invasion through Tumor-Stromal Interactions
Data from A Secreted Form of ADAM9 Promotes Carcinoma Invasion through Tumor-Stromal Interactions Open
Tumor cell invasion is a process regulated by integrins, matrix-degrading enzymes, and interactions with host tissue stromal cells. The ADAM family of proteins plays an important role in modulating various cellular responses. Here, we show…
View article: Hepatic non-parenchymal S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis
Hepatic non-parenchymal S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis Open
Unrestrained ketogenesis leads to life-threatening ketoacidosis whose incidence is high in patients with diabetes. While insulin therapy reduces ketogenesis this approach is sub-optimal. Here, we report an insulin-independent pathway able …
View article: Hepatic p63 regulates glucose metabolism by repressing SIRT1
Hepatic p63 regulates glucose metabolism by repressing SIRT1 Open
Objective p63 is a transcription factor within the p53 protein family that has key roles in development, differentiation and prevention of senescence, but its metabolic actions remain largely unknown. Herein, we investigated the physiologi…
View article: O-GlcNAcylated p53 in the liver modulates hepatic glucose production
O-GlcNAcylated p53 in the liver modulates hepatic glucose production Open
p53 regulates several signaling pathways to maintain the metabolic homeostasis of cells and modulates the cellular response to stress. Deficiency or excess of nutrients causes cellular metabolic stress, and we hypothesized that p53 could b…
View article: Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis
Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis Open
Skeletal muscle promotes metabolic balance by regulating glucose uptake and the stimulation of multiple interorgan crosstalk. We show here that the catalytic activity of Vav2, a Rho GTPase activator, modulates the signaling output of the I…
View article: Manipulation of dietary amino acids prevents and reverses obesity in mice through multiple mechanisms that modulate energy homeostasis
Manipulation of dietary amino acids prevents and reverses obesity in mice through multiple mechanisms that modulate energy homeostasis Open
Reduced activation of energy metabolism increases adiposity in humans and other mammals. Thus, exploring dietary and molecular mechanisms able to improve energy metabolism is of paramount medical importance, as such mechanisms can be lever…
View article: Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis
Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis Open
Reduced activation of energy metabolism increases adiposity in humans and other mammals. Thus, exploring dietary and molecular mechanisms able to improve energy metabolism is of paramount medical importance because such mechanisms can be l…
View article: Manipulation of dietary amino acids prevents and reverses obesity in mice through multiple mechanisms that modulate energy homeostasis
Manipulation of dietary amino acids prevents and reverses obesity in mice through multiple mechanisms that modulate energy homeostasis Open
Reduced activation of energy metabolism increases adiposity in humans and other mammals. Thus, exploring dietary and molecular mechanisms able to improve energy metabolism is of paramount medical importance, as such mechanisms can be lever…
View article: Insulin under the influence of light
Insulin under the influence of light Open
The discovery and administration of exogenous insulin has revolutionised diabetes treatment and continues, almost 100 years on, to be the basis for the management of insulin deficiency. However, insulin therapy still has potentially life-t…
View article: FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth
FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth Open
Cancer therapy is limited, in part, by lack of specificity. Thus, identifying molecules that are selectively expressed by, and relevant for, cancer cells is of paramount medical importance. Here, we show that peptidyl-prolyl-cis-trans-isom…
View article: Light Entrains Diurnal Changes in Insulin Sensitivity of Skeletal Muscle via Ventromedial Hypothalamic Neurons
Light Entrains Diurnal Changes in Insulin Sensitivity of Skeletal Muscle via Ventromedial Hypothalamic Neurons Open
Loss of synchrony between geophysical time and insulin action predisposes to metabolic diseases. Yet the brain and peripheral pathways linking proper insulin effect to diurnal changes in light-dark and feeding-fasting inputs are poorly und…
View article: SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity
SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity Open
AMPK is a cellular gauge that is activated under conditions of low energy, increasing energy production and reducing energy waste. Current evidence links hypothalamic AMPK with the central regulation of energy balance. However, it is uncle…
View article: Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance
Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance Open
Obesity-induced inflammation engenders insulin resistance and type 2 diabetes mellitus (T2DM) but the inflammatory effectors linking obesity to insulin resistance are incompletely understood. Here, we show that hepatic expression of Protei…
View article: SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity
SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity Open
Cancer stem cells (CSCs) have high tumorigenic capacity. Here, we show that stem-like traits of specific human cancer cells are reduced by overexpression of the histone deacetylase sirtuin 6 (SIRT6). SIRT6-sensitive cancer cells bear mutat…