R. Corsini
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View article: Radiochromic film dosimetry for VHEE and UHDR: protocol adaptation and verification at the CLEAR facility
Radiochromic film dosimetry for VHEE and UHDR: protocol adaptation and verification at the CLEAR facility Open
Radiochromic films (RCFs) offer effective two-dimensional dosimetry with a simple, low-cost operating principle, making them suitable for very high-energy electron (VHEE) and ultra-high dose rate (UHDR) applications, where dosimetry standa…
View article: Vacinação Em Neonatos E Lactentes: Segurança E Eficácia.
Vacinação Em Neonatos E Lactentes: Segurança E Eficácia. Open
View article: Demonstration and characterisation of a novel dual-scattering system for very high energy electrons
Demonstration and characterisation of a novel dual-scattering system for very high energy electrons Open
This article describes the design and implementation of the first known prototype of a dual-scattering system for the delivery of a uniform VHEE beam with transverse dimensions suitable for pre-clinical and potential future clinical use. T…
View article: Performance of High-Intensity Electron Linacs as Drivers for Compact Neutron Sources
Performance of High-Intensity Electron Linacs as Drivers for Compact Neutron Sources Open
The demand for neutron production facilities is increasing, as the applications of neutron science are manifold. These applications drive the need for efficient and compact neutron sources. In this context, this paper explores the potentia…
View article: Modification of the microstructure of the CERN- CLEAR-VHEE beam at the picosecond scale modifies ZFE morphogenesis but has no impact on hydrogen peroxide production
Modification of the microstructure of the CERN- CLEAR-VHEE beam at the picosecond scale modifies ZFE morphogenesis but has no impact on hydrogen peroxide production Open
Our findings suggest that scanning strategies employing high intensity beamlets may be optimal for the clinical implementation of FLASH radiotherapy. These insights are pivotal for guiding the development of future FLASH protocols in radia…
View article: Feasibility of High-Intensity Electron Linacs as Drivers for Compact Neutron Sources
Feasibility of High-Intensity Electron Linacs as Drivers for Compact Neutron Sources Open
View article: The Linear Collider Facility (LCF) at CERN
The Linear Collider Facility (LCF) at CERN Open
In this paper we outline a proposal for a Linear Collider Facility as the next flagship project for CERN. It offers the opportunity for a timely, cost-effective and staged construction of a new collider that will be able to comprehensively…
View article: Modification of the microstructure of the CERN- CLEAR-VHEE beam at the picosecond scale modifies ZFE morphogenesis but has no impact on hydrogen peroxide production
Modification of the microstructure of the CERN- CLEAR-VHEE beam at the picosecond scale modifies ZFE morphogenesis but has no impact on hydrogen peroxide production Open
FLASH has emerged as a significant breakthrough for the future of radiation oncology, as it reduces complications while preserving the tumor killing efficacy. To define the beam parameters for future clinical translation, Very High Energy …
View article: Spatially fractionated radiotherapy with very high energy electron pencil beam scanning
Spatially fractionated radiotherapy with very high energy electron pencil beam scanning Open
Objective. To evaluate spatially fractionated radiation therapy (SFRT) for very-high-energy electrons (VHEEs) delivered with pencil beam scanning. Approach . Radiochromic film was irradiated at the CERN linear electron accelerator for rese…
View article: Active dosimetry for VHEE FLASH radiotherapy using beam profile monitors and charge measurements
Active dosimetry for VHEE FLASH radiotherapy using beam profile monitors and charge measurements Open
View article: VHEE FLASH sparing effect measured at CLEAR, CERN with DNA damage of pBR322 plasmid as a biological endpoint
VHEE FLASH sparing effect measured at CLEAR, CERN with DNA damage of pBR322 plasmid as a biological endpoint Open
Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy tissue, an effect known as ‘FLASH’. This effect has been studied across several radiation modalities, including photons, protons and clinical energy…
View article: CERN-based experiments and Monte-Carlo studies on focused dose delivery with very high energy electron (VHEE) beams for radiotherapy applications
CERN-based experiments and Monte-Carlo studies on focused dose delivery with very high energy electron (VHEE) beams for radiotherapy applications Open
View article: Development of a novel fibre optic beam profile and dose monitor for very high energy electron radiotherapy at ultrahigh dose rates
Development of a novel fibre optic beam profile and dose monitor for very high energy electron radiotherapy at ultrahigh dose rates Open
Objective . Very high energy electrons (VHEE) in the range of 50–250 MeV are of interest for treating deep-seated tumours with FLASH radiotherapy (RT). This approach offers favourable dose distributions and the ability to deliver ultra-hig…
View article: Mini-GRID radiotherapy on the CLEAR very-high-energy electron beamline: collimator optimization, film dosimetry, and Monte Carlo simulations
Mini-GRID radiotherapy on the CLEAR very-high-energy electron beamline: collimator optimization, film dosimetry, and Monte Carlo simulations Open
Objective. Spatially-fractionated radiotherapy (SFRT) delivered with a very-high-energy electron (VHEE) beam and a mini-GRID collimator was investigated to achieve synergistic normal tissue-sparing through spatial fractionation and the FLA…
View article: Plastic scintillator dosimetry of ultrahigh dose-rate 200 MeV electrons at CLEAR
Plastic scintillator dosimetry of ultrahigh dose-rate 200 MeV electrons at CLEAR Open
Very high energy electron (VHEE) beams with energies greater than 100 MeV may be promising candidates for FLASH radiotherapy due to their favourable dose distributions and accessibility of ultrahigh dose-rates (UHDR). Combining VHEE with t…
View article: CERN-based Experiments and Monte Carlo Simulations on Focused VHEE (Very High Energy Electron) Beams For Radiotherapy
CERN-based Experiments and Monte Carlo Simulations on Focused VHEE (Very High Energy Electron) Beams For Radiotherapy Open
Very High Energy Electrons (VHEEs) are a promising alternative to conventional radiotherapy due to their highly penetratingnature and their applicability as a modality for FLASH (ultra-high dose rate) radiotherapy. The dose distributions d…
View article: CLIC Wake Field Monitor as a detuned Cavity Beam Position Monitor: Explanation of center offset between TE and TM channels in the TD26 structure
CLIC Wake Field Monitor as a detuned Cavity Beam Position Monitor: Explanation of center offset between TE and TM channels in the TD26 structure Open
The Wake Field Monitor (WFM) system installed on the CLIC prototype accelerating structure in CERN Linear Accelerator for Research (CLEAR) has two channels for each horizontal/vertical plane, operating at different frequencies. When moving…
View article: The effect of ground motion on the LHC and HL-LHC beam orbit
The effect of ground motion on the LHC and HL-LHC beam orbit Open
View article: A beam position monitor for electron bunch detection in the presence of a more intense proton bunch for the AWAKE Experiment
A beam position monitor for electron bunch detection in the presence of a more intense proton bunch for the AWAKE Experiment Open
The Advanced Proton Driven Plasma Wakefield Experiment (AWAKE) at CERN uses 6 cm long proton bunches extracted from the Super Proton Synchrotron (SPS) at 400 GeV beam energy to drive high gradient plasma wakefields for the acceleration of …
View article: The CLIC project
The CLIC project Open
The Compact Linear Collider (CLIC) is a multi-TeV high-luminosity linear e$^+$e$^-$-collider under development by the CLIC accelerator collaboration, hosted by CERN. The CLIC accelerator has been optimised for three energy stages at centre…
View article: Analysis of the Photoneutron Field Near the THz Dump of the CLEAR Accelerator at CERN With SEU Measurements and Simulations
Analysis of the Photoneutron Field Near the THz Dump of the CLEAR Accelerator at CERN With SEU Measurements and Simulations Open
We study the radiation environment near the terahertz (THz) dump of the CERN Linear Electron Accelerator for Research (CLEAR) electron accelerator at CERN, using FLUktuierende KAskade in German (FLUKA) simulations and single-event upset (S…
View article: A Compact Inverse Compton Scattering Source Based on X-Band Technology and Cavity-Enhanced High Average Power Ultrafast Lasers
A Compact Inverse Compton Scattering Source Based on X-Band Technology and Cavity-Enhanced High Average Power Ultrafast Lasers Open
A high-pulse-current injector followed by a short high-gradient X-band linac is considered as a driver for a compact Inverse Compton Scattering source. We show that using a high-power ultrashort pulse laser operating in burst mode and a Fa…
View article: VHEE High Dose Rate Dosimetry Studies in CLEAR
VHEE High Dose Rate Dosimetry Studies in CLEAR Open
The 200 MeV electron beam of the CERN Linear Accelerator for Research (CLEAR) user facility at CERN has been intensively used to study the potential use of Very High Energy Electrons (VHEE) in cancer radiotherapy. In particular, irradiatio…
View article: Updates, Status and Experiments of CLEAR, the CERN Linear Electron Accelerator for Research
Updates, Status and Experiments of CLEAR, the CERN Linear Electron Accelerator for Research Open
The CERN Linear Accelerator for Research (CLEAR) at CERN is a test facility using a 200 MeV electron beam. In 2020 and 2021, a few hardware upgrades were done: comparators for position measurements were added on components, the in-air expe…
View article: Strong focusing gradient in a linear active plasma lens
Strong focusing gradient in a linear active plasma lens Open
Active plasma lenses are compact devices developed as a promising beam-focusing alternative for charged particle beams, capable of short focal lengths for high-energy beams. We have previously shown that linear magnetic fields with gradien…
View article: The Large Hadron–Electron Collider at the HL-LHC
The Large Hadron–Electron Collider at the HL-LHC Open
The Large Hadron–Electron Collider (LHeC) is designed to move the field of deep inelastic scattering (DIS) to the energy and intensity frontier of particle physics. Exploiting energy-recovery technology, it collides a novel, intense electr…
View article: An experimental study of focused very high energy electron beams for radiotherapy
An experimental study of focused very high energy electron beams for radiotherapy Open
View article: Evaluating very high energy electron RBE from nanodosimetric pBR322 plasmid DNA damage
Evaluating very high energy electron RBE from nanodosimetric pBR322 plasmid DNA damage Open
View article: Consolidation and Future Upgrades to the CLEAR User Facility at CERN
Consolidation and Future Upgrades to the CLEAR User Facility at CERN Open
The CERN Linear Electron Accelerator for Research (CLEAR) at CERN has been operating since 2017 as a dedicated user facility providing beams for a varied range of experiments. CLEAR consists of a 20 m long linear accelerator (linac), able …
View article: Status of VHEE Radiotherapy Related Studies at the CLEAR User Facility at CERN
Status of VHEE Radiotherapy Related Studies at the CLEAR User Facility at CERN Open
Despite the increase in interest in using Very High Energy Electron (VHEE) beams for cancer radiotherapy many unanswered questions in its development remain. The use of test facilities will be an essential tool used to solve these issues. …