Roberto Fedrigo
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View article: Development of lesion and organ negative cast modelling technique for quality assurance and optimization of nuclear medicine images
Development of lesion and organ negative cast modelling technique for quality assurance and optimization of nuclear medicine images Open
The NCM method has potential to enable more realistic phantom studies within nuclear medicine imaging. The cost for the lymphoma tumour phantom study is less than $400 USD, making it feasible for large-scale studies.
View article: PyTomography: A python library for medical image reconstruction
PyTomography: A python library for medical image reconstruction Open
There is a need for open-source libraries in emission tomography that (i) use modern and popular backend code to encourage community contributions and (ii) offer support for the multitude of reconstruction techniques available in recent li…
View article: Neural blind deconvolution for deblurring and supersampling PSMA PET
Neural blind deconvolution for deblurring and supersampling PSMA PET Open
Objective . To simultaneously deblur and supersample prostate specific membrane antigen (PSMA) positron emission tomography (PET) images using neural blind deconvolution. Approach . Blind deconvolution is a method of estimating the hypothe…
View article: Development of the quantitative PET prostate phantom (Q3P) for improved quality assurance of <sup>18</sup>F‐PSMA PET imaging in metastatic prostate cancer
Development of the quantitative PET prostate phantom (Q3P) for improved quality assurance of <sup>18</sup>F‐PSMA PET imaging in metastatic prostate cancer Open
Background Phantoms are commonly used to evaluate and compare the performance of imaging systems given the known ground truth. Positron emission tomography (PET) scanners are routinely validated using the NEMA image quality phantom, in whi…
View article: PyTomography: A Python Library for Medical Image Reconstruction
PyTomography: A Python Library for Medical Image Reconstruction Open
There is a need for open-source libraries in emission tomography that (i) use modern and popular backend code to encourage community contributions and (ii) offer support for the multitude of reconstruction techniques available in recent li…
View article: Observer study-based evaluation of TGAN architecture used to generate oncological PET images
Observer study-based evaluation of TGAN architecture used to generate oncological PET images Open
The application of computer-vision algorithms in medical imaging has\nincreased rapidly in recent years. However, algorithm training is challenging\ndue to limited sample sizes, lack of labeled samples, as well as privacy\nconcerns regardi…
View article: Development of scalable lymphatic system in the 4D XCAT phantom: Application to quantitative evaluation of lymphoma PET segmentations
Development of scalable lymphatic system in the 4D XCAT phantom: Application to quantitative evaluation of lymphoma PET segmentations Open
Background Digital anthropomorphic phantoms, such as the 4D extended cardiac‐torso (XCAT) phantom, are actively used to develop, optimize, and evaluate a variety of imaging applications, allowing for realistic patient modeling and knowledg…
View article: Design of an anthropomorphic PET phantom with elastic lungs and respiration modeling
Design of an anthropomorphic PET phantom with elastic lungs and respiration modeling Open
Purpose Respiratory motion during positron emission tomography (PET) scans can be a major detriment to image quality in oncological imaging, leading to loss of quantification accuracy and false negative findings. The impact of motion on le…
View article: Quantitative evaluation of PSMA PET imaging using a realistic anthropomorphic phantom and shell-less radioactive epoxy lesions
Quantitative evaluation of PSMA PET imaging using a realistic anthropomorphic phantom and shell-less radioactive epoxy lesions Open
Background Positron emission tomography (PET) with prostate specific membrane antigen (PSMA) have shown superior performance in detecting metastatic prostate cancers. Relative to [ 18 F]fluorodeoxyglucose ([ 18 F]FDG) PET images, PSMA PET …
View article: An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 1: Design and Early Results of the SNMMI Dosimetry Challenge
An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 1: Design and Early Results of the SNMMI Dosimetry Challenge Open
In this work, we present details and initial results from a 177Lu dosimetry challenge that has been designed to collect data from the global nuclear medicine community aiming at identifying, understanding, and quantitatively characterizing…
View article: Quantitative Evaluation of PSMA PET Imaging using a Realistic Anthropomorphic Phantom and Shell-less Radioactive Epoxy Lesions
Quantitative Evaluation of PSMA PET Imaging using a Realistic Anthropomorphic Phantom and Shell-less Radioactive Epoxy Lesions Open
Background Prostate specific membrane antigen (PSMA) PET images have shown superior performance in detecting metastatic prostate cancers. Relative to [18F]FDG PET images, PSMA PET images tend to visualize significantly higher-contrast foca…
View article: Development of the Lymphatic System in the 4D XCAT Phantom
Development of the Lymphatic System in the 4D XCAT Phantom Open
Purpose: The XCAT phantom allows for highly sophisticated multimodality imaging research. It includes a complete set of organs, muscle, bone, soft tissue, while also accounting for age, sex, and body mass index (BMI), which allows phantom …
View article: Quantitative PET/CT Imaging for Enhanced Evaluation of Prostate Cancer and Lymphoma
Quantitative PET/CT Imaging for Enhanced Evaluation of Prostate Cancer and Lymphoma Open
Positron Emission Tomography (PET) scans offer valuable insight into the progression of diseases, such as cancer. However, there is evidence that quantitative imaging metrics can enhance the prognostic value of PET and its ability to effec…
View article: Design of an anthropomorphic PET phantom with elastic lungs and respiration modeling
Design of an anthropomorphic PET phantom with elastic lungs and respiration modeling Open
Purpose Respiratory motion during positron emission tomography (PET) scans can be a major detriment to image quality in oncological imaging, leading to loss of quantification accuracy and false negative findings. The impact of motion on le…
View article: Design of an Anthropomorphic Respiratory Phantom for PET Imaging
Design of an Anthropomorphic Respiratory Phantom for PET Imaging Open
Purpose Respiratory motion during positron emission tomography (PET) scans can be a major detriment to image quality in oncological imaging, leading to loss of quantification accuracy and false negative findings. The impact of motion on le…
View article: Monte Carlo simulation of 6‐MV dynamic wave VMAT deliveries by Vero4DRT linear accelerator using EGSnrc moving sources
Monte Carlo simulation of 6‐MV dynamic wave VMAT deliveries by Vero4DRT linear accelerator using EGSnrc moving sources Open
The commissioning and benchmark of a Monte Carlo (MC) model of the 6‐MV Brainlab‐Mitsubishi Vero4DRT linear accelerator for the purpose of quality assurance of clinical dynamic wave arc (DWA) treatment plans is reported. Open‐source MC app…