Roberto Giacomelli
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View article: Pain catastrophizing and its domains significantly impact rheumatoid arthritis disease activity
Pain catastrophizing and its domains significantly impact rheumatoid arthritis disease activity Open
This study aims to evaluate the impact of pain catastrophizing (PC) on disease activity in patients with rheumatoid arthritis (RA) and to explore, in the same participants, if this association is related or not with anxiety and depression,…
View article: Sex-Based Differences in Systemic Sclerosis Among Egyptian Patients: Insights from a Multicenter Observational Study in a Genetically Distinct North African Mediterranean Population
Sex-Based Differences in Systemic Sclerosis Among Egyptian Patients: Insights from a Multicenter Observational Study in a Genetically Distinct North African Mediterranean Population Open
Background: Systemic Sclerosis (SSc) is a heterogeneous autoimmune disease with variable clinical expression influenced by genetic, environmental, and sex-related factors. Understanding sex-based differences in disease phenotypes and sever…
View article: Seasonal variation influences fibromyalgia severity in terms of widespread pain among female patients: data from a large national registry
Seasonal variation influences fibromyalgia severity in terms of widespread pain among female patients: data from a large national registry Open
View article: Transcriptomic profiling of Sjögren’s disease salivary glands identifies signatures associated with both follicular and extrafollicular responses linked to rheumatoid factor and anti-La/SSB seropositivity
Transcriptomic profiling of Sjögren’s disease salivary glands identifies signatures associated with both follicular and extrafollicular responses linked to rheumatoid factor and anti-La/SSB seropositivity Open
Comprehensive SG bulk-RNA sequencing provided the first transcriptomic evidence of distinct RF and anti-La/SSB-driven SG transcriptomic signatures in patients with SjD with and without ELS. These findings suggest that both classical follic…
View article: Hopelessness is associated to severity of both digital vasculopathy and lung disease in systemic sclerosis patients: a prospective one-year study
Hopelessness is associated to severity of both digital vasculopathy and lung disease in systemic sclerosis patients: a prospective one-year study Open
Hopelessness is common in SSc and linked to lung severity and digital vasculopathy, highlighting the importance of targeting hand function and pulmonary disease to improve psycho-social wellbeing.
View article: Co-Occurrence of Anti-Synthetase Syndrome and Sjögren Disease: A Case-Based Review
Co-Occurrence of Anti-Synthetase Syndrome and Sjögren Disease: A Case-Based Review Open
Background: Anti-synthetase Syndrome (ASyS) is an idiopathic inflammatory myopathy characterized by muscle weakness and inflammatory infiltrates in muscles. Sjogren’s disease (SD) is an autoimmune condition primarily affecting exocrine gla…
View article: Specialized pro-resolving mediators and autoimmunity: Recent insights and future perspectives
Specialized pro-resolving mediators and autoimmunity: Recent insights and future perspectives Open
Inflammation is a response to injuries involving multiple cellular and molecular mechanisms. Different stimuli, such as trauma or microbial invasion, trigger an acute inflammatory response consisting, at least in principle, of two phases: …
View article: Type II diabetes in systemic sclerosis patients: insights from an observational, multicenter study of GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale)
Type II diabetes in systemic sclerosis patients: insights from an observational, multicenter study of GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) Open
View article: Upadacitinib regulates pain-related pathways and BDNF expression in human monocyte-derived microglial-like cells
Upadacitinib regulates pain-related pathways and BDNF expression in human monocyte-derived microglial-like cells Open
Chronic pain is one of the most critical symptoms reported by patients with inflammatory arthritis, and even when joint inflammation improves, disabling residual pain may persist in a significant number of patients. Microglial cells, by pr…
View article: Mediterranean diet and its low-antigenic and anti-inflammatory properties on fibromyalgia: a systematic review
Mediterranean diet and its low-antigenic and anti-inflammatory properties on fibromyalgia: a systematic review Open
The articles studied within this review show that there is a relationship between the gut and how FM symptoms can be affected. They suggest that placing patients with early symptoms of FM on a Mediterranean diet may have a low to moderate …
View article: 2023 International Rome consensus for the nomenclature of Sjögren disease
2023 International Rome consensus for the nomenclature of Sjögren disease Open
View article: ABS0953 THE RELATIONSHIP BETWEEN METABOLIC SYNDROME AND PAIN CATASTROPHIZING IN PATIENTS WITH PSORIATIC ARTHRITIS
ABS0953 THE RELATIONSHIP BETWEEN METABOLIC SYNDROME AND PAIN CATASTROPHIZING IN PATIENTS WITH PSORIATIC ARTHRITIS Open
View article: POS0243 MITOCHONDRIAL DYSFUNCTION ACTIVATES THE cGAS-STING PATHWAY, CONTRIBUTING TO INTERFERON PRODUCTION IN SYSTEMIC SCLEROSIS
POS0243 MITOCHONDRIAL DYSFUNCTION ACTIVATES THE cGAS-STING PATHWAY, CONTRIBUTING TO INTERFERON PRODUCTION IN SYSTEMIC SCLEROSIS Open
View article: POS0696 REVEALING A DISTINCT INTERFERON-RESPONSE CLUSTER IN SSc BLOOD MONOCYTES
POS0696 REVEALING A DISTINCT INTERFERON-RESPONSE CLUSTER IN SSc BLOOD MONOCYTES Open
View article: ABS0476 THE ROLE OF C-REACTIVE PROTEIN IN SJOGREN DISEASE
ABS0476 THE ROLE OF C-REACTIVE PROTEIN IN SJOGREN DISEASE Open
View article: ABS0158 THE ASSESSMENT OF IL-15 IN PATIENTS WITH STILL'S DISEASE, IN VITRO AND EX-VIVO FINDINGS
ABS0158 THE ASSESSMENT OF IL-15 IN PATIENTS WITH STILL'S DISEASE, IN VITRO AND EX-VIVO FINDINGS Open
View article: Ultrasound in rheumatic and musculoskeletal diseases: From musculoskeletal to organ involvement
Ultrasound in rheumatic and musculoskeletal diseases: From musculoskeletal to organ involvement Open
In last two decades, the use of ultrasound has assumed an increasingly important role in the assessment of almost all rheumatic and musculoskeletal diseases. Over the years, much advancement has been made in the sonographic evaluation of a…
View article: Patients with psoriatic arthritis and comorbid metabolic syndrome show a difficult-to-treat phenotype: another mosaic tile in the definition of a still undefined subset of patients
Patients with psoriatic arthritis and comorbid metabolic syndrome show a difficult-to-treat phenotype: another mosaic tile in the definition of a still undefined subset of patients Open
Objective Psoriatic arthritis (PsA) is a chronic inflammatory condition associated with psoriasis and characterised by heterogeneous clinical manifestations, including peripheral and axial arthritis, enthesitis and dactylitis. A subset of …
View article: The Relationship Between Metabolic Syndrome and Pain Catastrophizing in Psoriatic Arthritis
The Relationship Between Metabolic Syndrome and Pain Catastrophizing in Psoriatic Arthritis Open
Introduction Psoriatic arthritis (PsA) is a complex inflammatory disease often associated with metabolic syndrome (MetS). It has been demonstrated that pain catastrophizing (PC), characterized by an exaggerated negative cognitive and emoti…
View article: Influence of gender on Behçet's disease phenotype and irreversible organ damage: Data from the International AIDA Network Behçet's Disease Registry
Influence of gender on Behçet's disease phenotype and irreversible organ damage: Data from the International AIDA Network Behçet's Disease Registry Open
View article: Diminished expression of the ubiquitin-proteasome system in early treatment-naïve patients with rheumatoid arthritis and concomitant type 2 diabetes may be linked to IL-1 pathway hyper-activity; results from PEAC cohort
Diminished expression of the ubiquitin-proteasome system in early treatment-naïve patients with rheumatoid arthritis and concomitant type 2 diabetes may be linked to IL-1 pathway hyper-activity; results from PEAC cohort Open
View article: Geographical disparities in fibromyalgia severity: An Italian study
Geographical disparities in fibromyalgia severity: An Italian study Open
Background Geographic origin may represent a variable capable of influencing health status. This study aims to investigate the presence of differences of disease severity in Italian patients with fibromyalgia from different macro‐regions. …
View article: Pain catastrophizing negatively impacts drug retention rate in patients with Psoriatic Arthritis and axial Spondyloarthritis: results from a 2-years perspective multicenter GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica) study
Pain catastrophizing negatively impacts drug retention rate in patients with Psoriatic Arthritis and axial Spondyloarthritis: results from a 2-years perspective multicenter GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica) study Open
View article: Clinical and subclinical atherosclerosis in patients with systemic sclerosis: an observational, multicentre study of GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale)
Clinical and subclinical atherosclerosis in patients with systemic sclerosis: an observational, multicentre study of GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) Open
A higher prevalence of clinical and subclinical atherosclerosis was detected in SSc Italian patients and correlated with traditional and SSc-related risk factors.
View article: The Systemic Score May Identify Life‐Threatening Evolution in Still Disease: Data from the GIRRCS AOSD‐Study Group and the AIDA Network Still Disease Registry
The Systemic Score May Identify Life‐Threatening Evolution in Still Disease: Data from the GIRRCS AOSD‐Study Group and the AIDA Network Still Disease Registry Open
Objective We aimed to evaluate the clinical usefulness of the systemic score in the prediction of life‐threatening evolution in Still disease. We also aimed to assess the clinical relevance of each component of the systemic score in predic…
View article: Real‐world effectiveness and persistence of golimumab as second‐line <scp>anti‐TNFα</scp> drug in rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis patients in Italy: <scp>GO‐BEYOND</scp>, a 12‐month prospective observational study
Real‐world effectiveness and persistence of golimumab as second‐line <span>anti‐TNFα</span> drug in rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis patients in Italy: <span>GO‐BEYOND</span>, a 12‐month prospective observational study Open
A high proportion of patients may fail a first-line anti-TNF drug, necessitating the switch to another anti-TNF treatment. After 12 months of GLM treatment, 80% of RA patients achieved low disease activity (LDA), 37.1% with PsA achieved mi…
View article: Increased Prevalence of Headaches and Migraine in Patients with Psoriatic Arthritis and Axial Spondyloarthritis: Insights from an Italian Cohort Study
Increased Prevalence of Headaches and Migraine in Patients with Psoriatic Arthritis and Axial Spondyloarthritis: Insights from an Italian Cohort Study Open
Background: Psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) are inflammatory diseases with shared genetic backgrounds and clinical comorbidities. Headache, a common global health issue, affects over 50% of adults and encompas…
View article: Idiopathic and connective tissue disease-associated pulmonary arterial hypertension (PAH): Similarities, differences and the role of autoimmunity
Idiopathic and connective tissue disease-associated pulmonary arterial hypertension (PAH): Similarities, differences and the role of autoimmunity Open
View article: The effects of suppressing inflammation by tofacitinib may simultaneously improve glycaemic parameters and inflammatory markers in rheumatoid arthritis patients with comorbid type 2 diabetes: a proof-of-concept, open, prospective, clinical study
The effects of suppressing inflammation by tofacitinib may simultaneously improve glycaemic parameters and inflammatory markers in rheumatoid arthritis patients with comorbid type 2 diabetes: a proof-of-concept, open, prospective, clinical study Open
Background A consistent connection has been increasingly reported between rheumatoid arthritis (RA), insulin resistance (IR), and type 2 diabetes (T2D). The β-cell apoptosis induced by pro-inflammatory cytokines, which could be exaggerated…
View article: Using ZOOM-events for Scientific Conferences: The ICHEP 2022 Experience
Using ZOOM-events for Scientific Conferences: The ICHEP 2022 Experience Open
The organization of seminars and conferences was strongly influenced by the covid-19 pandemic. In the early period of the pandemic, many events were canceled or held completely online, using video conferencing tools such as ZOOM or MS Team…