Carlos Gil Ferreira
YOU?
Author Swipe
View article: Intracranial activity of sotorasib vs docetaxel in pretreated KRAS G12C-mutated advanced non-small cell lung cancer from a global, phase 3, randomized controlled trial
Intracranial activity of sotorasib vs docetaxel in pretreated KRAS G12C-mutated advanced non-small cell lung cancer from a global, phase 3, randomized controlled trial Open
NCT04303780.
View article: Genome-wide identification and characterization caleosin genes in lima-bean (Phaseolus lunatus)
Genome-wide identification and characterization caleosin genes in lima-bean (Phaseolus lunatus) Open
Phaseolus lunatus, commonly known as lima bean or butter bean, is a leguminous crop with significant agricultural and nutritional value, particularly in tropical regions. Caleosin, a lipid-associated protein, plays a crucial role in seed g…
View article: Sotorasib versus docetaxel for previously treated KRAS G12C–mutated non–small–cell lung cancer: a plain language summary
Sotorasib versus docetaxel for previously treated KRAS G12C–mutated non–small–cell lung cancer: a plain language summary Open
What is this summary about? The CodeBreaK 200 clinical study included patients with a type of lung cancer called non–small-cell lung cancer that has spread outside the lung (advanced) and had a particular change (mutation) in the KRAS gene…
View article: Brazilian real-world data of immunotherapy in extensive stage small cell lung cancer
Brazilian real-world data of immunotherapy in extensive stage small cell lung cancer Open
Introduction The landmarks of Thoracic Oncology in the last two decades have been accompanied by exponential growth in costs, making it imperative to assess the real benefit of incorporating new technologies. Combining immunotherapy (IO) w…
View article: Pooled safety analysis and management of sotorasib-related adverse events in <i>KRAS</i> G12C-mutated advanced non-small cell lung cancer
Pooled safety analysis and management of sotorasib-related adverse events in <i>KRAS</i> G12C-mutated advanced non-small cell lung cancer Open
Introduction We describe the safety of sotorasib monotherapy in patients with KRAS G12C-mutated advanced non-small cell lung cancer (NSCLC) and discuss practical recommendations for managing key risks. Methods Incidence rates of treatment-…
View article: Later lines of systemic therapy in patients with metastatic colorectal cancer: real-world data from a setting with barriers to access cancer therapies
Later lines of systemic therapy in patients with metastatic colorectal cancer: real-world data from a setting with barriers to access cancer therapies Open
In a real-world setting with barriers to accessing the standard of care of chemorefractory mCRC, reexposure to chemotherapy was the main therapeutic strategy, with potential negative influence on OS. Our study highlights how barriers hampe…
View article: Real-World Study on Implementation of Genomic Tests for Advanced Lung Adenocarcinoma in Brazil
Real-World Study on Implementation of Genomic Tests for Advanced Lung Adenocarcinoma in Brazil Open
PURPOSE Tissue inadequacy and operational challenges may limit lung cancer comprehensive biomarker testing. Here, we describe the initial implementation of a tailored tissue molecular journey at Oncoclínicas Precision Medicine Laboratory i…
View article: Unveiling the Landscape of Brazilian Clinical Oncologists: Challenges, Diversity, and Quality Care
Unveiling the Landscape of Brazilian Clinical Oncologists: Challenges, Diversity, and Quality Care Open
Cancer remains a significant public health challenge in Brazil, with an estimated 704 thousand new cases annually. Clinical oncology, a pivotal specialty in cancer diagnosis and treatment, has evolved since its formal establishment in 1946…
View article: Head and neck squamous cell carcinoma epidemiology at diagnosis: A description of public and private health care systems in Brazil regarding tumor location, staging and risk factors
Head and neck squamous cell carcinoma epidemiology at diagnosis: A description of public and private health care systems in Brazil regarding tumor location, staging and risk factors Open
Objectives: There is a limited number of updated epidemiological Brazilian data on head and neck squamous cell carcinoma (HNSCC). This study aimed to describe demographic and clinical characteristics of HNSCC patients from Brazilian public…
View article: Next-generation sequencing impact on cancer care: applications, challenges, and future directions
Next-generation sequencing impact on cancer care: applications, challenges, and future directions Open
Fundamentally precision oncology illustrates the path in which molecular profiling of tumors can illuminate their biological behavior, diversity, and likely outcomes by identifying distinct genetic mutations, protein levels, and other biom…
View article: Implementation of a Cancer Care Line: Experience of a Brazilian Private Oncology Institution
Implementation of a Cancer Care Line: Experience of a Brazilian Private Oncology Institution Open
Advances in technology and medical treatment have made cancer treatment more complex.With an extensive schedule of exams, consultations and procedures, which require speed, the cancer patient's journey is a challenge.Mainly in Brazil, a co…
View article: Preventive and therapeutic assessment program for mucositis in patients with cancer: promising advances in stomatological care
Preventive and therapeutic assessment program for mucositis in patients with cancer: promising advances in stomatological care Open
Objectives: We propose a preventive and therapeutic assessment program for mucositis in patients with cancer based on a comprehensive review of scientific evidence. Material and Methods: This methodological study, designed as a non-systema…
View article: Fifteen years of precision medicine in the lung cancer management: Perspectives and Challenges
Fifteen years of precision medicine in the lung cancer management: Perspectives and Challenges Open
Precision medicine has revolutionized lung cancer management – particularly non-squamous cell carcinomas – with a broader genomic comprehension and the possibility of offering tailored treatments guided by oncogenic driver mutations – the …
View article: The average cost of treatment according to lung cancer stage using real-world data
The average cost of treatment according to lung cancer stage using real-world data Open
Introduction: Immunotherapy led to increased survival in advanced non-small cell lung cancer; however, it has also increased treatment costs. In this study, real-world data was used to evaluate the average cost of treatment of patients wit…
View article: Editorial: Molecular genetic testing and emerging targeted therapies for non-small cell lung cancer
Editorial: Molecular genetic testing and emerging targeted therapies for non-small cell lung cancer Open
EDITORIAL article Front. Oncol., 23 November 2023Sec. Thoracic Oncology Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1308525
View article: Cost Evaluation Analysis of Genetic Testing and Tailored Adjuvant Imatinib in Patients With Resected High-Risk GI Stromal Tumors: The Brazilian Perspective
Cost Evaluation Analysis of Genetic Testing and Tailored Adjuvant Imatinib in Patients With Resected High-Risk GI Stromal Tumors: The Brazilian Perspective Open
PURPOSE Mutations of the KIT gene are the molecular hallmark of most GI stromal tumors (GISTs). Imatinib has revolutionized GIST treatment. Adjuvant imatinib for 3 years is the standard of care for high-risk resected GIST. However, the GIS…
View article: EGFR Mutation Detection in Brazilian Patients With Non–Small-Cell Lung Cancer: Lessons From Real-World Data Scenario of Molecular Testing
EGFR Mutation Detection in Brazilian Patients With Non–Small-Cell Lung Cancer: Lessons From Real-World Data Scenario of Molecular Testing Open
PURPOSE There is a paucity of consistent data concerning genetic mutations in Brazilian patients with lung cancer. The aim of this study was to retrospectively analyze epidermal growth factor receptor (EGFR) mutations detected in a real-wo…
View article: A short review of the main concerns in A.I. development and application within the public sector supported by NLP and TM
A short review of the main concerns in A.I. development and application within the public sector supported by NLP and TM Open
Artificial Intelligence is not a new subject, and business, industry and public sectors have used it in different ways and contexts and considering multiple concerns. This work reviewed research papers published in ACM Digital Library and …
View article: Supplementary Figure 6 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer
Supplementary Figure 6 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer Open
Supplementary Figure 6. Increased levels of IL-6 in bronchoalveolar lavage fluid (BALF) of CC-LR mice after NTHi exposure.
View article: Supplementary Figure 1 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer
Supplementary Figure 1 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer Open
Supplementary Figure 1. Gating method for FACS analysis and sorting.
View article: Supplementary Figure 4 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer
Supplementary Figure 4 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer Open
Supplementary Figure 4. Lung lesion distribution in lungs of CC-LR mice.
View article: Supplementary Table 1, Supplementary Methods, and Supplementary Figure Legends from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer
Supplementary Table 1, Supplementary Methods, and Supplementary Figure Legends from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer Open
Table 1. List of Q-RT-PCR primers. Supplementary methods and supplementary figure legends.
View article: Supplementary Figure 7 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer
Supplementary Figure 7 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer Open
Supplementary Figure 7. Relative expression of Scgb1 (CCSP) mRNA in lungs of CC-LR mice.
View article: Supplementary Figure 3 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer
Supplementary Figure 3 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer Open
Supplementary Figure 3. Increased levels of IL-6 in bronchoalveolar lavage fluid (BALF) of CC-LR mice during tumor progression.
View article: Supplementary Figure 7 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer
Supplementary Figure 7 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer Open
Supplementary Figure 7. Relative expression of Scgb1 (CCSP) mRNA in lungs of CC-LR mice.
View article: Supplementary Figure 1 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer
Supplementary Figure 1 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer Open
Supplementary Figure 1. Gating method for FACS analysis and sorting.