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View article: CardioPulmonary resuscitation with Argon (CPAr): A protocol for a randomised controlled multicentre clinical trial
CardioPulmonary resuscitation with Argon (CPAr): A protocol for a randomised controlled multicentre clinical trial Open
View article: Beta-blockers after myocardial infarction: effects according to sex in the REBOOT trial
Beta-blockers after myocardial infarction: effects according to sex in the REBOOT trial Open
Background and Aims Recent trials have challenged the guideline recommendation of beta-blockers for post-myocardial infarction (MI) patients without reduced left ventricular ejection fraction (LVEF). Whether these recent findings apply equ…
View article: When Real-World Outcomes Do Not Meet the Results of Clinical Trials: Transfemoral Transcatheter vs. Surgical Aortic Valve Replacement in an Intermediate-Age Population (The Outstanding Italy Study)
When Real-World Outcomes Do Not Meet the Results of Clinical Trials: Transfemoral Transcatheter vs. Surgical Aortic Valve Replacement in an Intermediate-Age Population (The Outstanding Italy Study) Open
Objective: Aortic valve stenosis is the most common valvular heart disease in the elderly, and its treatment may be either surgical (SAVR) or transcatheter (TAVI). Although age is one of the main determinants of the therapeutic choice, cur…
View article: KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation
KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation Open
Cerebral cavernous malformation (CCM) is a neurovascular disease distinguished by clusters of leaky, mulberry-like blood vessels. KRIT1 bi-allelic loss-of-function mutations in endothelial cells are known to trigger brain cavernomas; howev…
View article: Developing a Randomised Efficacy PREcision medicine Platform trial design for Cavernomas: the CARE PREP study
Developing a Randomised Efficacy PREcision medicine Platform trial design for Cavernomas: the CARE PREP study Open
Background Symptomatic cerebral cavernous malformations are a rare sporadic or familial disease, which may cause haemorrhagic strokes or epileptic seizures. In 2015, a James Lind Alliance Priority Setting Partnership ranked targeted drug t…
View article: Ceramide and phosphatidylcholine lipids‐based risk score predicts major cardiovascular outcomes in patients with heart failure
Ceramide and phosphatidylcholine lipids‐based risk score predicts major cardiovascular outcomes in patients with heart failure Open
Background Ceramide and phosphatidylcholine lipids‐based risk score (CERT2) has shown a strong prognostic value in predicting cardiovascular (CV) events in patients with ischemic heart disease. This study aimed to investigate the prognosti…
View article: Evolution of brain injury and neurological dysfunction after cardiac arrest in the rat – A multimodal and comprehensive model
Evolution of brain injury and neurological dysfunction after cardiac arrest in the rat – A multimodal and comprehensive model Open
Cardiac arrest (CA) is one of the leading causes of death worldwide. Due to hypoxic ischemic brain injury, CA survivors may experience variable degrees of neurological dysfunction. This study, for the first time, describes the progression …
View article: Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis
Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis Open
View article: Patient-reported outcome measures in patients with familial cerebral cavernous malformations: results from the Treat_CCM trial
Patient-reported outcome measures in patients with familial cerebral cavernous malformations: results from the Treat_CCM trial Open
Background The Phase 1/2 Treat_CCM randomized controlled trial for people with familial cerebral cavernous malformations (FCCMs) confirmed the safety of propranolol and suggested beneficial effects on intracerebral hemorrhage or new focal …
View article: Dataset related to article "Patient-reported outcome measures in patients with familial cerebral cavernous malformations: results from the Treat_CCM trial"
Dataset related to article "Patient-reported outcome measures in patients with familial cerebral cavernous malformations: results from the Treat_CCM trial" Open
Excel file with data related to the article.
View article: Dataset related to article "Patient-reported outcome measures in patients with familial cerebral cavernous malformations: results from the Treat_CCM trial"
Dataset related to article "Patient-reported outcome measures in patients with familial cerebral cavernous malformations: results from the Treat_CCM trial" Open
Excel file with data related to the article.
View article: Dataset related to article "Indoleamine 2,3-dioxygenase deletion to modulate kynurenine pathway and to prevent brain injury after cardiac arrest in mice"
Dataset related to article "Indoleamine 2,3-dioxygenase deletion to modulate kynurenine pathway and to prevent brain injury after cardiac arrest in mice" Open
Excel file containing data related to the article
View article: Dataset related to article "Indoleamine 2,3-dioxygenase deletion to modulate kynurenine pathway and to prevent brain injury after cardiac arrest in mice"
Dataset related to article "Indoleamine 2,3-dioxygenase deletion to modulate kynurenine pathway and to prevent brain injury after cardiac arrest in mice" Open
Excel file containing data related to the article
View article: Post-cardiac arrest temporal evolution of left ventricular function in a rat model: speckle-tracking echocardiography and cardiac circulating biomarkers
Post-cardiac arrest temporal evolution of left ventricular function in a rat model: speckle-tracking echocardiography and cardiac circulating biomarkers Open
Aims There is little information from experimental studies regarding the evolution of post-resuscitation cardiac arrest [post-return of spontaneous circulation (post-ROSC)] myocardial dysfunction during mid-term follow-up. For this purpose…
View article: Circulating biomarkers in familial cerebral cavernous malformation
Circulating biomarkers in familial cerebral cavernous malformation Open
View article: Metabolic syndrome cardiovascular risk prevention by omega-3 polyunsaturated fatty acids
Metabolic syndrome cardiovascular risk prevention by omega-3 polyunsaturated fatty acids Open
View article: Indoleamine 2,3-Dioxygenase Deletion to Modulate Kynurenine Pathway and to Prevent Brain Injury after Cardiac Arrest in Mice
Indoleamine 2,3-Dioxygenase Deletion to Modulate Kynurenine Pathway and to Prevent Brain Injury after Cardiac Arrest in Mice Open
Background The catabolism of the essential amino acid tryptophan to kynurenine is emerging as a potential key pathway involved in post–cardiac arrest brain injury. The aim of this study was to evaluate the effects of the modulation of kynu…
View article: Characterization of the Cardiac Structure and Function of Conscious D2.B10-Dmdmdx/J (D2-mdx) mice from 16–17 to 24–25 Weeks of Age
Characterization of the Cardiac Structure and Function of Conscious D2.B10-Dmdmdx/J (D2-mdx) mice from 16–17 to 24–25 Weeks of Age Open
Duchenne muscular dystrophy (DMD) is the most common form of muscle degenerative hereditary disease. Muscular replacement by fibrosis and calcification are the principal causes of progressive and severe musculoskeletal, respiratory, and ca…
View article: Prognostic value of secretoneurin in chronic heart failure. Data from the GISSI-Heart Failure trial
Prognostic value of secretoneurin in chronic heart failure. Data from the GISSI-Heart Failure trial Open
View article: P252 THE TREATMENT WITH BETA–BLOCKERS AFTER MYOCARDIAL INFARCTION WITHOUT REDUCED EJECTION FRACTION (REBOOT) TRIAL, 2023 UPDATES
P252 THE TREATMENT WITH BETA–BLOCKERS AFTER MYOCARDIAL INFARCTION WITHOUT REDUCED EJECTION FRACTION (REBOOT) TRIAL, 2023 UPDATES Open
Introduction The role of beta blockers (BB) post–myocardial infarction (MI) in patients without reduced ejection fraction in the era of invasive management is controversial results from observational studies have led to opposite results. M…
View article: Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study
Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study Open
Background: We sought to identify protein biomarkers of new-onset heart failure (HF) in 3 independent cohorts (HOMAGE cohort [Heart Omics and Ageing], ARIC study [Atherosclerosis Risk in Communities], and FHS [Framingham Heart Study]) and …
View article: Amplitude Spectrum Area of ventricular fibrillation to guide defibrillation: a small open-label, pseudo-randomized controlled multicenter trial
Amplitude Spectrum Area of ventricular fibrillation to guide defibrillation: a small open-label, pseudo-randomized controlled multicenter trial Open
View article: Effects of hyperoxemia in patients with sepsis – A post-hoc analysis of a multicentre randomized clinical trial
Effects of hyperoxemia in patients with sepsis – A post-hoc analysis of a multicentre randomized clinical trial Open
In a post-hoc analysis of a RCT enrolling septic patients, hyperoxemia as average PaO2>100 mmHg during the first 48 h was not associated with patients' survival.
View article: Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial
Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial Open
View article: Circulating secretoneurin concentrations provide independent prognostic information to established risk indices in patients with chronic heart failure
Circulating secretoneurin concentrations provide independent prognostic information to established risk indices in patients with chronic heart failure Open
Background Secretoneurin (SN) is a 33-amino acid peptide that directly influences cardiomyocyte Ca2+ handling. Circulating SN concentrations increase in situations of systemic stress, myocardial dysfunction, and renal failure, and SN conce…
View article: Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials
Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials Open
View article: Markers of neutrophil mediated inflammation associate with disturbed continuous electroencephalogram after out of hospital cardiac arrest
Markers of neutrophil mediated inflammation associate with disturbed continuous electroencephalogram after out of hospital cardiac arrest Open
Background Achieving an acceptable neurological outcome in cardiac arrest survivors remains challenging. Ischemia‐reperfusion injury induces inflammation, which may cause secondary neurological damage. We studied the association of ICU adm…
View article: Circulating levels and prognostic cut‐offs of sST2, hs‐cTnT, and NT‐proBNP in women vs. men with chronic heart failure
Circulating levels and prognostic cut‐offs of sST2, hs‐cTnT, and NT‐proBNP in women vs. men with chronic heart failure Open
Aims To define plasma concentrations, determinants, and optimal prognostic cut‐offs of soluble suppression of tumorigenesis‐2 (sST2), high‐sensitivity cardiac troponin T (hs‐cTnT), and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) …
View article: Predictive value of HDL function in patients with coronary artery disease: relationship with coronary plaque characteristics and clinical events
Predictive value of HDL function in patients with coronary artery disease: relationship with coronary plaque characteristics and clinical events Open
HDL is endowed with several metabolic, vascular, and immunoinflammatory protective functions. Among them, a key property is to promote reverse cholesterol transport from cells back to the liver. The aim of this study was to estimate the as…
View article: Comparing and contrasting risk factors for heart failure in patients with and without history of myocardial infarction: data from <scp>HOMAGE</scp> and the <scp>UK</scp> Biobank
Comparing and contrasting risk factors for heart failure in patients with and without history of myocardial infarction: data from <span>HOMAGE</span> and the <span>UK</span> Biobank Open
Aims Myocardial infarction (MI) is among the commonest attributable risk factors for heart failure (HF). We compared clinical characteristics associated with the progression to HF in patients with or without a history of MI in the HOMAGE c…