Roberto Massari
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View article: Targeting the <scp>MDM2</scp> ‐ <scp>MDM4</scp> interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer
Targeting the <span>MDM2</span> ‐ <span>MDM4</span> interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer Open
Targeting the heterodimer MDM2/MDM4 is a novel and effective route for the reactivation of wild‐type p53 in human tumors with reduced toxicity in nontransformed cells. To improve the therapeutic potential of peptides that interfere with MD…
View article: Inhalation of nanoplastics in the mouse model: Tissue bio-distribution and effects on the olfactory system
Inhalation of nanoplastics in the mouse model: Tissue bio-distribution and effects on the olfactory system Open
The impact of plastic fragments on human health is currently under investigation, with nanoplastics (NPs) being particularly concerning due to their small size. This allows them to be inhaled, pass through blood barriers, and reach various…
View article: Exploring swine oviduct anatomy through micro-computed tomography: a 3D modeling perspective
Exploring swine oviduct anatomy through micro-computed tomography: a 3D modeling perspective Open
The oviduct plays a crucial role in the reproductive process, serving as the stage for fertilization and the early stages of embryonic development. When the environment of this organ has been mimicked, it has been shown to enhance in vitro…
View article: Intracerebellar administration of the chemokine Cxcl3 reduces the volume of medulloblastoma lesions at an advanced stage by promoting the migration and differentiation of preneoplastic precursor cells
Intracerebellar administration of the chemokine Cxcl3 reduces the volume of medulloblastoma lesions at an advanced stage by promoting the migration and differentiation of preneoplastic precursor cells Open
The prognosis for many pediatric brain tumors, including cerebellar medulloblastoma (MB), remains dismal but there is promise in new therapies. We have previously generated a mouse model developing spontaneous MB at high frequency, Ptch1 +…
View article: Radiolabelled FGF-2 for Imaging Activated Fibroblasts in the Tumor Micro-Environment
Radiolabelled FGF-2 for Imaging Activated Fibroblasts in the Tumor Micro-Environment Open
Tumor associated fibroblasts (TAFs) play a key role in tumor growth and metastatization. TAFs overexpress different biomarkers that are usually expressed at low levels in physiological conditions. Among them are the fibroblast growth facto…
View article: Editorial: New trends in single photon emission computed tomography (SPECT)
Editorial: New trends in single photon emission computed tomography (SPECT) Open
EDITORIAL article Front. Med., 20 December 2023Sec. Nuclear Medicine Volume 10 - 2023 | https://doi.org/10.3389/fmed.2023.1349877
View article: Development of a High-resolution SSR-SPECT System for Preclinical Imaging and Neuroimaging
Development of a High-resolution SSR-SPECT System for Preclinical Imaging and Neuroimaging Open
The utility of animal models in preclinical research has been increasing by the availability of methods for in vivo imaging. In particular, techniques like single photon emission computed tomography (SPECT) show high potential, which is us…
View article: Role of Nuclear Imaging to Understand the Neural Substrates of Brain Disorders in Laboratory Animals: Current Status and Future Prospects
Role of Nuclear Imaging to Understand the Neural Substrates of Brain Disorders in Laboratory Animals: Current Status and Future Prospects Open
Molecular imaging, which allows the real-time visualization, characterization and measurement of biological processes, is becoming increasingly used in neuroscience research. Scintigraphy techniques such as single photon emission computed …
View article: Organ-on-chip model shows that ATP release through connexin hemichannels drives spontaneous Ca<sup>2+</sup> signaling in non-sensory cells of the greater epithelial ridge in the developing cochlea
Organ-on-chip model shows that ATP release through connexin hemichannels drives spontaneous Ca<sup>2+</sup> signaling in non-sensory cells of the greater epithelial ridge in the developing cochlea Open
Using microfluidics, ATP biosensors, multiphoton microscopy and genetically targeted mice, we show that ATP release through connexin hemichannels, and not pannexin 1 channels, underlies spontaneous Ca2+ wave propagation in the greater epit…