Roberto Patarca
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View article: Protein Functional Effector (pfe) Noncoding RNAS Are Identical to Fragments from Various Noncoding RNAs
Protein Functional Effector (pfe) Noncoding RNAS Are Identical to Fragments from Various Noncoding RNAs Open
Protein functional effector (pfe)RNAs were introduced in 2015 as PIWI-interacting-like small noncoding (nc)RNAs and were later categorized as a novel group based on being 2′-O-methylated at their 3′-end, directly binding and affecting prot…
View article: Protein Functional Effector (pfe) Noncoding RNAS are Identical to Fragments from Various Noncoding RNAs
Protein Functional Effector (pfe) Noncoding RNAS are Identical to Fragments from Various Noncoding RNAs Open
Protein functional effector (pfe)RNAs were introduced in 2015 as PIWI-interacting-like small noncoding (nc)RNAs and later categorized as a novel group. Here, we document that human 3’-end 2’-O-methylated, protein-binding pfeRNAs match frag…
View article: RNA Structure: Past, Future, and Gene Therapy Applications
RNA Structure: Past, Future, and Gene Therapy Applications Open
First believed to be a simple intermediary between the information encoded in deoxyribonucleic acid and that functionally displayed in proteins, ribonucleic acid (RNA) is now known to have many functions through its abundance and intricate…
View article: RNA Structure: Past, Future, and Gene Therapy Applications
RNA Structure: Past, Future, and Gene Therapy Applications Open
First believed to be a simple intermediary between the information encoded in deoxyribonucleic acid and that functionally displayed in proteins, ribonucleic acid (RNA) is now known to have many functions through its abundance and intricate…
View article: RNA Structure: Historical and Future Perspectives
RNA Structure: Historical and Future Perspectives Open
First believed to be a simple intermediary between the information encoded in deoxyribonucleic acid and that functionally displayed in proteins, ribonucleic acid (RNA) is now known to have many functions through its abundance and intricate…
View article: The RNA Revolution in the Central Molecular Biology Dogma Evolution
The RNA Revolution in the Central Molecular Biology Dogma Evolution Open
Human genome projects in the 1990s identified about 20,000 protein-coding sequences. We are now in the RNA revolution, propelled by the realization that genes determine phenotype beyond the foundational central molecular biology dogma, sta…
View article: The RNA Revolution in the Central Molecular Biology Dogma Evolution
The RNA Revolution in the Central Molecular Biology Dogma Evolution Open
Human genome projects in the 1990s identified about 20,000 protein-coding sequences. We are now in the RNA revolution, propelled by the realization that genes determine phenotype beyond the foundational central molecular biology dogma stat…
View article: Potential Transcriptional Enhancers in Coronaviruses: From Infectious Bronchitis Virus to SARS-CoV-2
Potential Transcriptional Enhancers in Coronaviruses: From Infectious Bronchitis Virus to SARS-CoV-2 Open
Coronaviruses constitute a global threat to human and animal health. It is essential to investigate the long-distance RNA-RNA interactions that approximate remote regulatory elements in strategies, including genome circularization, discont…
View article: Potential Transcriptional Enhancers in Coronaviruses: From Infectious Bronchitis Virus to SARS-CoV-2
Potential Transcriptional Enhancers in Coronaviruses: From Infectious Bronchitis Virus to SARS-CoV-2 Open
Coronaviruses constitute a global threat to human and animal health. It is essential to investigate the long-distance RNA-RNA interactions that approximate remote regulatory elements in strategies, including genome circularization, discont…
View article: Bioinformatics Insights on Viral Gene Expression Transactivation: From HIV-1 to SARS-CoV-2
Bioinformatics Insights on Viral Gene Expression Transactivation: From HIV-1 to SARS-CoV-2 Open
Viruses provide vital insights into gene expression control. Viral transactivators, with other viral and cellular proteins, regulate expression of self, other viruses, and host genes with profound effects on infected cells, underlying infl…
View article: Bioinformatics Insights on Viral Gene Expression Transactivation: From HIV-1 to SARS-CoV-2
Bioinformatics Insights on Viral Gene Expression Transactivation: From HIV-1 to SARS-CoV-2 Open
Viruses continue to provide vital insights into the field of control of gene expression. Viral transactivators, in concert with other viral and cellular proteins, regulate expression of self, other viruses, and host genes with profound eff…
View article: Experimental encephalomyelitis at age 90, still relevant and elucidating how viruses trigger disease
Experimental encephalomyelitis at age 90, still relevant and elucidating how viruses trigger disease Open
20 yr ago, a tribute appeared in this journal on the 70th anniversary of an animal model of disseminated encephalomyelitis, abbreviated EAE for experimental autoimmune encephalomyelitis. “Observations on Attempts to Produce Disseminated En…
View article: Intragenomic rearrangements in SARS-CoV-2, other betacoronaviruses, and alphacoronaviruses
Intragenomic rearrangements in SARS-CoV-2, other betacoronaviruses, and alphacoronaviruses Open
Variation of the betacoronavirus SARS-CoV-2 has been the bane of COVID-19 control. Documented variation includes point mutations, deletions, insertions, and recombination among closely or distantly related coronaviruses. Here, we describe …
View article: Structural flexibility of the SARS-CoV-2 genome relevant to variation, replication, pathogenicity, and immune evasion
Structural flexibility of the SARS-CoV-2 genome relevant to variation, replication, pathogenicity, and immune evasion Open
The SARS-CoV-2 pandemic continues to be driven by viral variants. Most research has focused on structural proteins and on site-specific mutations. Here, we describe recombination events involving genomic terminal sequences in SARS-CoV-2 an…
View article: Hot topics in interventional cardiology: Proceedings from the society for cardiovascular angiography and interventions (SCAI) 2021 think tank
Hot topics in interventional cardiology: Proceedings from the society for cardiovascular angiography and interventions (SCAI) 2021 think tank Open
The Society for Cardiovascular Angiography and Interventions (SCAI) Think Tank is a collaborative venture that brings together interventional cardiologists, administrative partners, and select members of the cardiovascular industry communi…
View article: Physician Modified Low Profile Endograft for Endovascular Repair of Juxtarenal Abdominal Aortic Aneurysms in Patients with Small Access Vessels
Physician Modified Low Profile Endograft for Endovascular Repair of Juxtarenal Abdominal Aortic Aneurysms in Patients with Small Access Vessels Open
Based on two case experiences, the use of physician modified off the shelf endografts appears to be a feasible and effective alternative to fenestrated endovascular repair in patients with juxtarenal abdominal aortic aneurysms at high risk…
View article: Hot topics in interventional cardiology: Proceedings from the society for cardiovascular angiography and interventions 2020 think tank
Hot topics in interventional cardiology: Proceedings from the society for cardiovascular angiography and interventions 2020 think tank Open
The society for cardiovascular angiography and interventions (SCAI) think tank is a collaborative venture that brings together interventional cardiologists, administrative partners, and select members of the cardiovascular industry communi…