Roberto Quesada
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Identification of the atypical antipsychotic Asenapine as a direct survivin inhibitor with anticancer properties and sensitizing effects to conventional therapies Open
Therapy resistance in human cancers is a major limitation in Clinical Oncology. In this regard, overexpression of anti-apoptotic proteins, such as survivin, has been described in several tumors, contributing to this clinical issue. Survivi…
Deregulation of lactate permeability using a small-molecule transporter (Lactrans-1) disturbs intracellular pH and triggers cancer cell death Open
Due to the relevance of lactic acidosis in cancer, several therapeutic strategies have been developed targeting its production and/or regulation. In this matter, inhibition approaches of key proteins such as lactate dehydrogenase or monoca…
Harnessing unprotected deactivated amines and arylglyoxals in the Ugi reaction for the synthesis of fused complex nitrogen heterocycles Open
Piperazines and diazepines are examples of nitrogen heterocycles present in many marketed drugs highlighting their importance in the discovery of novel bioactive compounds. However, their synthesis often faces challenges, including complex…
CCDC 2269059: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2269058: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2269060: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2269057: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2269061: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2182742: Experimental Crystal Structure Determination
CCDC 2182742: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2258886: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
Synthesis of Tetrahydronaphthoazetidinones, 2,5‐Dioxo‐1,4‐methanobenzoazepines and 3‐Hydroxypyrrolidinones Through Copper‐Assisted Post‐Ugi Reactions Open
Copper‐assisted post‐Ugi reactions enable access to different heterocyclic systems, tetrahydronaphthoazetidinone, 2,5‐dioxo‐1,4‐methanobenzoazepine and 3‐hydroxypyrrolidinone derivatives. The described process affords complex scaffolds fro…
CCDC 2244226: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
Supplementary File 1 from Novel Indole-based Tambjamine-Analogues Induce Apoptotic Lung Cancer Cell Death through p38 Mitogen-Activated Protein Kinase Activation Open
QIAGEN Cancer Drug Targets Array file containing the raw data (Ct information) for the qPCR of all the conditions (both A549 and SW900 cell lines).
Data from Novel Indole-based Tambjamine-Analogues Induce Apoptotic Lung Cancer Cell Death through p38 Mitogen-Activated Protein Kinase Activation Open
Lung cancer has become the leading killer cancer worldwide, due to late diagnosis and lack of efficient anticancer drugs. We have recently described novel natural-derived tambjamine analogues that are potent anion transporters capable of d…
Supplementary Figures S1-S42, Supplementary Tables S1-S2, and Supplementary Materials and Methods from Novel Indole-based Tambjamine-Analogues Induce Apoptotic Lung Cancer Cell Death through p38 Mitogen-Activated Protein Kinase Activation Open
Supplementary Figures: Figure S1. Set of tambjamine analogues investigated; Figure S2. General reaction scheme; Figure S3. 1H NMR (DMSO-d6) of compound 3.HCl; Figure S4. 13C (DMSO-d6) of compound 3.HCl; Figure S5. HRMS (EI) of compound 3; …
Data from Novel Indole-based Tambjamine-Analogues Induce Apoptotic Lung Cancer Cell Death through p38 Mitogen-Activated Protein Kinase Activation Open
Lung cancer has become the leading killer cancer worldwide, due to late diagnosis and lack of efficient anticancer drugs. We have recently described novel natural-derived tambjamine analogues that are potent anion transporters capable of d…
Supplementary Figures S1-S42, Supplementary Tables S1-S2, and Supplementary Materials and Methods from Novel Indole-based Tambjamine-Analogues Induce Apoptotic Lung Cancer Cell Death through p38 Mitogen-Activated Protein Kinase Activation Open
Supplementary Figures: Figure S1. Set of tambjamine analogues investigated; Figure S2. General reaction scheme; Figure S3. 1H NMR (DMSO-d6) of compound 3.HCl; Figure S4. 13C (DMSO-d6) of compound 3.HCl; Figure S5. HRMS (EI) of compound 3; …
Supplementary File 1 from Novel Indole-based Tambjamine-Analogues Induce Apoptotic Lung Cancer Cell Death through p38 Mitogen-Activated Protein Kinase Activation Open
QIAGEN Cancer Drug Targets Array file containing the raw data (Ct information) for the qPCR of all the conditions (both A549 and SW900 cell lines).
Anticooperative Supramolecular Oligomerization Mediated by V‐Shaped Monomer Design and Unconventional Hydrogen Bonds Open
After more than three decades of extensive investigations on supramolecular polymers, strategies for self‐limiting growth still remain challenging. Herein, we exploit a new V‐shaped monomer design to achieve anticooperatively formed oligom…
Anticooperative Supramolecular Oligomerization Mediated by V‐Shaped Monomer Design and Unconventional Hydrogen Bonds Open
After more than three decades of extensive investigations on supramolecular polymers, strategies for self‐limiting growth still remain challenging. Herein, we exploit a new V‐shaped monomer design to achieve anticooperatively formed oligom…
Formulation and evaluation of anion transporters in nanostructured lipid carriers Open
Nanostructured lipid carriers (NLCs) can be used to efficiently formulate highly lipophilic anionophores. These formulations are able to deliver these compounds to phospholipid membranes maintaining their anion transport activity.
Antimetastatic Properties of Prodigiosin and the BH3-Mimetic Obatoclax (GX15-070) in Melanoma Open
Metastasis is the primary cause of death in cancer patients. Many current chemotherapeutic agents only show cytotoxic, but not antimetastatic properties. This leads to a reduction in tumor size, but allows cancer cells to disseminate, whic…
CCDC 2193430: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2194712: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2193426: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2193429: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2194745: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2193435: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …