Robin Bartolini
YOU?
Author Swipe
View article: Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza
Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza Open
Inflammatory chemokine receptors CCR1/2/3/5 (iCCRs) play an important role in the recruitment of immune cells involved in innate immune functions and orchestrating the adaptive immune response. Here we utilise an influenza A virus (IAV) ch…
View article: Enrichment of CD7+CXCR3+ CAR T-cells in infusion products is associated with durable remission in relapsed or refractory diffuse large B-cell lymphoma
Enrichment of CD7+CXCR3+ CAR T-cells in infusion products is associated with durable remission in relapsed or refractory diffuse large B-cell lymphoma Open
View article: Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza
Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza Open
Inflammatory chemokine receptors CCR1/2/3/5 (iCCRs) play an important role in the recruitment of immune cells involved in innate immune functions and orchestrating the adaptive immune response. Here we utilise an influenza A virus (IAV) ch…
View article: Tocilizumab and immune signatures for targeted management of cytokine release syndrome in immune checkpoint therapy
Tocilizumab and immune signatures for targeted management of cytokine release syndrome in immune checkpoint therapy Open
View article: Enhanced CCR2 expression by ACKR2-deficient NK cells increases tumoricidal cell therapy efficacy
Enhanced CCR2 expression by ACKR2-deficient NK cells increases tumoricidal cell therapy efficacy Open
Chemokines regulate leukocyte navigation to inflamed sites and specific tissue locales and may therefore be useful for ensuring accurate homing of cell therapeutic products. We, and others, have shown that atypical chemokine receptor 2 (AC…
View article: CCR1 and CCR2 Coexpression on Monocytes Is Nonredundant and Delineates a Distinct Monocyte Subpopulation
CCR1 and CCR2 Coexpression on Monocytes Is Nonredundant and Delineates a Distinct Monocyte Subpopulation Open
The interactions between chemokines and their receptors, particularly in the context of inflammation, are complex, with individual receptors binding multiple ligands and individual ligands interacting with multiple receptors. In addition, …
View article: Distinct leukocyte populations and cytokine secretion profiles define tumoral and peritumoral areas in renal cell carcinoma
Distinct leukocyte populations and cytokine secretion profiles define tumoral and peritumoral areas in renal cell carcinoma Open
View article: Macrophage reprogramming—rather than depletion—is efficacious in a specific subset of colorectal tumor models
Macrophage reprogramming—rather than depletion—is efficacious in a specific subset of colorectal tumor models Open
Despite the abundance of macrophages in colorectal cancer (CRC), macrophage-targeted therapy has not demonstrated significant clinical benefit. Here, we show that macrophage populations differ across the consensus molecular subtypes (CMS) …
View article: M1/M2 macrophages and their overlaps – myth or reality?
M1/M2 macrophages and their overlaps – myth or reality? Open
Macrophages represent heterogeneous cell population with important roles in defence mechanisms and in homoeostasis. Tissue macrophages from diverse anatomical locations adopt distinct activation states. M1 and M2 macrophages are two polari…
View article: Supplementary Material for: Oncostatin M and nivolumab affect the cytotoxic T cell proportions and the susceptibility to TRAIL-induced death in non-leukocyte cell subpopulations in soft tissue sarcomas
Supplementary Material for: Oncostatin M and nivolumab affect the cytotoxic T cell proportions and the susceptibility to TRAIL-induced death in non-leukocyte cell subpopulations in soft tissue sarcomas Open
Introduction: Soft tissue sarcomas (STSs) are malignant tumors arising from mesenchymal tissues. Patients with advanced and metastatic STSs have low overall survival rates and relatively limited treatment options. Oncostatin M (OSM) is a p…
View article: Oncostatin M and Nivolumab Affect the Cytotoxic T-Cell Proportions and the Susceptibility to TRAIL-Induced Death in Non-Leukocyte Cell Subpopulations in Soft Tissue Sarcomas
Oncostatin M and Nivolumab Affect the Cytotoxic T-Cell Proportions and the Susceptibility to TRAIL-Induced Death in Non-Leukocyte Cell Subpopulations in Soft Tissue Sarcomas Open
Introduction: Soft tissue sarcomas (STSs) are malignant tumors arising from mesenchymal tissues. Patients with advanced and metastatic STSs have low overall survival rates and relatively limited treatment options. Oncostatin M (OSM) is a p…
View article: Inflammatory Chemokine Receptors Support Inflammatory Macrophage and Dendritic Cell Maturation
Inflammatory Chemokine Receptors Support Inflammatory Macrophage and Dendritic Cell Maturation Open
Dendritic cells form clusters in vivo, but the mechanism behind this has not been determined. In this article, we demonstrate that monocytes from mice deficient in the chemokine receptors CCR1, CCR2, CCR3, and CCR5 display reduced clusteri…
View article: Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice
Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice Open
Inflammatory chemokines and their receptors are central to the development of inflammatory/immune pathologies. The apparent complexity of this system, coupled with lack of appropriate in vivo models, has limited our understanding of how ch…
View article: Author response: Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice
Author response: Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Inflammatory chemokine…
View article: Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice
Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice Open
Summary Inflammatory chemokines and their receptors are central to the development of inflammatory/immune pathologies. The apparent complexity of this system, coupled with lack of appropriate in vivo models, has limited our understanding o…
View article: Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism
Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism Open
Atypical chemokine receptor 2 (ACKR2) is a chemokine-scavenging receptor. ACKR2-/-embryos display a reduction in size of a novel, to our knowledge, embryonic skin macrophage population referred to as 'intermediate' cells. CC chemokine rece…
View article: Chemokine Receptor Redundancy and Specificity Are Context Dependent
Chemokine Receptor Redundancy and Specificity Are Context Dependent Open
View article: Investigating the orchestration of the inflammatory response: a role for chemokine receptors CCR1, CCR2, CCR3 and CCR5
Investigating the orchestration of the inflammatory response: a role for chemokine receptors CCR1, CCR2, CCR3 and CCR5 Open
Despite over 20 years of pharmaceutical targeted research, no antagonist of inflammatory chemokine receptors (iCCR) has been licensed for use in treating inflammatory diseases. Marked promiscuity of ligand binding, simultaneous expression …