Robin Schubert
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View article: In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging
In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging Open
Background Huntington’s Disease (HD) is an inherited neurodegenerative disorder characterised by progressive cognitive and motor decline due to atrophy in basal ganglia networks. No disease-modifying therapies exist, but novel clinical tri…
View article: In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging
In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging Open
Background Huntington’s Disease (HD) is an inherited neurodegenerative disorder characterised by progressive cognitive and motor decline due to atrophy in basal ganglia networks. No disease-modifying therapies exist, but novel clinical tri…
View article: Digital Outcomes of Upper Limb Ataxia Capture Meaningful Longitudinal Change and Treatment Response
Digital Outcomes of Upper Limb Ataxia Capture Meaningful Longitudinal Change and Treatment Response Open
Background Digital‐motor outcomes promise better responsiveness than clinician‐reported outcomes in ataxia trials. However, their patient meaningfulness and sensitivity to change remain to be demonstrated, particularly in the upper limb do…
View article: In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging
In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging Open
Background Huntington’s Disease (HD) is an inherited neurodegenerative disorder characterised by progressive cognitive and motor decline due to atrophy in basal ganglia networks. No disease-modifying therapies exist, but novel clinical tri…
View article: The joint memory effect: challenging the selfish stigma in Huntington’s disease?
The joint memory effect: challenging the selfish stigma in Huntington’s disease? Open
The prevalent belief that individuals with Huntington’s disease exhibit selfish behaviour, disregarding the thoughts, feelings and actions of others, has been challenged by patient organizations and clinical experts. To further investigate…
View article: Protocol for a randomised controlled unblinded feasibility trial of HD-DRUM: a rhythmic movement training application for cognitive and motor symptoms in people with Huntington’s disease
Protocol for a randomised controlled unblinded feasibility trial of HD-DRUM: a rhythmic movement training application for cognitive and motor symptoms in people with Huntington’s disease Open
Introduction Huntington’s disease (HD) is an inherited neurodegenerative disease causing progressive cognitive and motor decline, largely due to basal ganglia (BG) atrophy. Rhythmic training offers promise as therapy to counteract BG-regul…
View article: Multifeature quantitative motor assessment of upper limb ataxia including drawing and reaching
Multifeature quantitative motor assessment of upper limb ataxia including drawing and reaching Open
Objective Voluntary upper limb movements are an ecologically important yet insufficiently explored digital‐motor outcome domain for trials in degenerative ataxia. We extended and validated the trial‐ready quantitative motor assessment batt…
View article: Protocol for a randomised controlled feasibility trial of HD-DRUM, a rhythmic movement training application for cognitive and motor symptoms in people with Huntington’s disease
Protocol for a randomised controlled feasibility trial of HD-DRUM, a rhythmic movement training application for cognitive and motor symptoms in people with Huntington’s disease Open
Introduction Huntington’s disease (HD) is an inherited neurodegenerative disease causing progressive cognitive and motor decline, largely due to basal ganglia (BG) atrophy. Rhythmic training offers promise as therapy to counteract BG-regul…
View article: LASSI-L detects early cognitive changes in pre-motor manifest Huntington’s disease: a replication and validation study
LASSI-L detects early cognitive changes in pre-motor manifest Huntington’s disease: a replication and validation study Open
Background and objectives Cognitive decline is an important early sign in pre-motor manifest Huntington’s disease (preHD) and is characterized by deficits across multiple domains including executive function, psychomotor processing speed, …
View article: A new approach to digitized cognitive monitoring: validity of the SelfCog in Huntington’s disease
A new approach to digitized cognitive monitoring: validity of the SelfCog in Huntington’s disease Open
Cognitive deficits represent a hallmark of neurodegenerative diseases, but evaluating their progression is complex. Most current evaluations involve lengthy paper-and-pencil tasks which are subject to learning effects dependent on the mode…
View article: Effects of age and sex on outcomes of the Q-Motor speeded finger tapping and grasping and lifting tests-findings from the population-based BiDirect Study
Effects of age and sex on outcomes of the Q-Motor speeded finger tapping and grasping and lifting tests-findings from the population-based BiDirect Study Open
Background Q-Motor is a suite of motor tests originally designed to assess motor symptoms in Huntington's disease. Among others, Q-Motor encompasses a finger tapping task and a grasping and lifting task. To date, there are no systematic in…
View article: Cognitive decline in Huntington’s disease in the Digitalized Arithmetic Task (DAT)
Cognitive decline in Huntington’s disease in the Digitalized Arithmetic Task (DAT) Open
Background Efficient cognitive tasks sensitive to longitudinal deterioration in small cohorts of Huntington’s disease (HD) patients are lacking in HD research. We thus developed and assessed the digitized arithmetic task (DAT), which combi…
View article: Correction to: Gait variability as digital biomarker of disease severity in Huntington’s disease
Correction to: Gait variability as digital biomarker of disease severity in Huntington’s disease Open
The original version of this article unfortunately contained a mistake. The name of one author is not presented correctly in the author group.
View article: A Feasibility Study of Quantitative Motor Assessments in Children Using the Q-Motor Suite
A Feasibility Study of Quantitative Motor Assessments in Children Using the Q-Motor Suite Open
Q-Motor is utilized across various clinical trials in adults with Huntington's disease (HD) to provide quantitative, reliable assessments of motor abilities. With gene-knockdown therapies entering the clinic, development of preventative th…
View article: Physical Activity and Exercise Outcomes in Huntington Disease (PACE-HD): Protocol for a 12-Month Trial Within Cohort Evaluation of a Physical Activity Intervention in People With Huntington Disease
Physical Activity and Exercise Outcomes in Huntington Disease (PACE-HD): Protocol for a 12-Month Trial Within Cohort Evaluation of a Physical Activity Intervention in People With Huntington Disease Open
Background Exercise is emerging as an important aspect in the management of disease-related symptoms and functional decline in people with Huntington disease (HD). Long-term evaluation of physical activity and exercise participation in HD …
View article: Supplementary Material for: Quantitative Measurements of Motor Function in Alzheimer’s Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies: A Proof-of-Concept Study
Supplementary Material for: Quantitative Measurements of Motor Function in Alzheimer’s Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies: A Proof-of-Concept Study Open
Background: This study examines the efficacy of using quantitative measurements of motor dysfunction, compared to clinical ratings, in Alzheimer’s disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB). Methods: I…
View article: Behavioral testing of minipigs transgenic for the Huntington gene—A three-year observational study
Behavioral testing of minipigs transgenic for the Huntington gene—A three-year observational study Open
The assessment battery presented offers measures in all domains relevant for HD and can be applied in long-term phenotyping studies with tgHD minipigs. The observation of this cohort should be continued to explore the timeline of phenotype…