Robin Ganesan
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View article: Pleiotropic effects of PAB1 deletion: Extensive changes in the yeast proteome, transcriptome, and translatome
Pleiotropic effects of PAB1 deletion: Extensive changes in the yeast proteome, transcriptome, and translatome Open
Cytoplasmic poly(A)-binding protein (PABPC; Pab1 in yeast) is thought to be involved in multiple steps of post-transcriptional control, including translation initiation, translation termination, and mRNA decay. To understand both the direc…
View article: Structural mechanism of angiogenin activation by the ribosome
Structural mechanism of angiogenin activation by the ribosome Open
Angiogenin, an RNase A-family protein, promotes angiogenesis and has been implicated in cancer, neurodegenerative diseases, and epigenetic inheritance. Upon activation during cellular stress, angiogenin cleaves tRNAs at the anticodon loop,…
View article: Direct and indirect consequences of<i>PAB1</i>deletion in the regulation of translation initiation, translation termination, and mRNA decay
Direct and indirect consequences of<i>PAB1</i>deletion in the regulation of translation initiation, translation termination, and mRNA decay Open
Cytoplasmic poly(A)-binding protein (PABPC; Pab1 in yeast) is thought to be involved in multiple steps of post-transcriptional control, including translation initiation, translation termination, and mRNA decay. To understand these roles of…
View article: Ribosome-bound Upf1 forms distinct 80S complexes and conducts mRNA surveillance
Ribosome-bound Upf1 forms distinct 80S complexes and conducts mRNA surveillance Open
Upf1, Upf2, and Upf3, the central regulators of nonsense-mediated mRNA decay (NMD), appear to exercise their NMD functions while bound to elongating ribosomes, and evidence for this conclusion is particularly compelling for Upf1. Hence, we…
View article: Progressive polysomal association of Upf1, Upf2, and Upf3 as ribosomes traverse mRNA coding regions
Progressive polysomal association of Upf1, Upf2, and Upf3 as ribosomes traverse mRNA coding regions Open
SUMMARY Upf1, Upf2, and Upf3 are the central regulators of nonsense-mediated mRNA decay (NMD), the eukaryotic mRNA quality control pathway generally triggered when a premature termination codon is recognized by the ribosome. The NMD-relate…
View article: Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae
Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae Open
Translation of mRNA into a polypeptide is terminated when the release factor eRF1 recognizes a UAA, UAG, or UGA stop codon in the ribosomal A site and stimulates nascent peptide release. However, stop codon readthrough can occur when a nea…
View article: Transcriptome-wide investigation of stop codon readthrough in <i>Saccharomyces cerevisiae</i>
Transcriptome-wide investigation of stop codon readthrough in <i>Saccharomyces cerevisiae</i> Open
Translation of mRNA into a polypeptide is terminated when the release factor eRF1 recognizes a UAA, UAG, or UGA stop codon in the ribosomal A site and stimulates nascent peptide release. However, stop codon readthrough can occur when a nea…