Robin Hamilton
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View article: Cohort profile: Design and methods for Project HERCULES (Healthcare Exemplar for Recovery from COVID 19 Using Linear Examination Systems): Multi-disciplinary implementation and evaluation of an asynchronous review clinic in NHS eye-care services
Cohort profile: Design and methods for Project HERCULES (Healthcare Exemplar for Recovery from COVID 19 Using Linear Examination Systems): Multi-disciplinary implementation and evaluation of an asynchronous review clinic in NHS eye-care services Open
Objectives To describe the research principles and cohort characteristics of the multi-disciplinary Project HERCULES, an innovative model of safe high-volume outpatient eye-care service for patients with stable chronic eye diseases. Result…
View article: The Impact of Disease Activity Criteria on Extending Injection Intervals in Real-World Patients with Neovascular Age-Related Macular Degeneration
The Impact of Disease Activity Criteria on Extending Injection Intervals in Real-World Patients with Neovascular Age-Related Macular Degeneration Open
Applying disease activity criteria from clinical trials to clinical practice can have a significant impact on hypothetical anti-VEGF injection intervals. Consideration should be paid to which criteria are used in real-world practice to hel…
View article: Improving Clinic Capacity with Faricimab
Improving Clinic Capacity with Faricimab Open
Clinic capacity constraints are an ever-increasing problem in ophthalmology. Multiple case studies demonstrate that faricimab frees up clinic capacity with extended treatment intervals in both treatment-naïve and treatment-experienced pati…
View article: Cohort profile: design and methods for Project HERCULES (Healthcare Exemplar for Recovery from COVID 19 by Use of Linear Examination Systems). Multi-disciplinary implementation and evaluation of an asynchronous review clinic for monitoring chronic eye disease in English NHS services
Cohort profile: design and methods for Project HERCULES (Healthcare Exemplar for Recovery from COVID 19 by Use of Linear Examination Systems). Multi-disciplinary implementation and evaluation of an asynchronous review clinic for monitoring chronic eye disease in English NHS services Open
Purpose To describe the research principles and cohort characteristics of the multidisciplinary Project HERCULES, which evaluated implementation of an innovative model of high-volume outpatient eyecare service to monitor patients with stab…
View article: Visual and Anatomical Outcomes of a Single Intravitreal Dexamethasone in Diabetic Macular Edema: An 8 Year Real-World Study
Visual and Anatomical Outcomes of a Single Intravitreal Dexamethasone in Diabetic Macular Edema: An 8 Year Real-World Study Open
Importance: Diabetic macular edema (DME) is a major cause of vision loss in patients with diabetes mellitus. Intravitreal dexamethasone is a treatment option for patients unsuitable for or non-responsive to anti-angiogenic agents. Objectiv…
View article: A Multi-Modal AI-Driven Cohort Selection Tool to Predict Suboptimal Non-Responders to Aflibercept Loading-Phase for Neovascular Age-Related Macular Degeneration: PRECISE Study Report 1
A Multi-Modal AI-Driven Cohort Selection Tool to Predict Suboptimal Non-Responders to Aflibercept Loading-Phase for Neovascular Age-Related Macular Degeneration: PRECISE Study Report 1 Open
Patients diagnosed with exudative neovascular age-related macular degeneration are commonly treated with anti-vascular endothelial growth factor (anti-VEGF) agents. However, response to treatment is heterogeneous, without a clinical explan…
View article: Exploring regression to the mean in visual acuities by investigating measurements at two consecutive time points in untreated fellow eyes
Exploring regression to the mean in visual acuities by investigating measurements at two consecutive time points in untreated fellow eyes Open
In clinical trials and real-world data, eyes with worse baseline vision frequently demonstrate greater visual benefit [1][2][3].This can be attributed to the "ceiling effect" of higher visual acuities (with less room for improvement).Somet…
View article: Standard threshold laser versus subthreshold micropulse laser for adults with diabetic macular oedema: the DIAMONDS non-inferiority RCT
Standard threshold laser versus subthreshold micropulse laser for adults with diabetic macular oedema: the DIAMONDS non-inferiority RCT Open
Background The National Institute for Health and Care Excellence recommends macular laser to treat diabetic macular oedema with a central retinal subfield thickness of < 400 µm on optical coherence tomography. The DIAMONDS (DIAbetic Macula…
View article: A multi-modal AI-driven cohort selection tool based on response to loading-phase aflibercept for neovascular age-related macular degeneration: PRECISE study
A multi-modal AI-driven cohort selection tool based on response to loading-phase aflibercept for neovascular age-related macular degeneration: PRECISE study Open
Patients diagnosed with neovascular age-related macular degeneration are commonly treated with anti-vascular endothelial growth factor (anti-VEGF) agents. However, response to treatment is heterogeneous, without a clinical explanation. Pre…
View article: Estimating excess visual loss from neovascular age-related macular degeneration in the UK during the COVID-19 pandemic: a retrospective clinical audit and simulation model
Estimating excess visual loss from neovascular age-related macular degeneration in the UK during the COVID-19 pandemic: a retrospective clinical audit and simulation model Open
Objectives To report the reduction in new neovascular age-related macular degeneration (nAMD) referrals during the COVID-19 pandemic and estimate the impact of delayed treatment on visual outcomes at 1 year. Design Retrospective clinical a…
View article: The changing landscape for the management of patients with neovascular AMD: brolucizumab in clinical practice
The changing landscape for the management of patients with neovascular AMD: brolucizumab in clinical practice Open
Untreated neovascular age-related macular degeneration (nAMD) can lead to severe and permanent visual impairment. The chronic nature of the disease can have a significant impact on patients’ quality of life and an economic and time burden …
View article: Supplementary Material for: Fluid control in neovascular age-related macular degeneration with brolucizumab: an analysis of the HAWK and HARRIER phase 3 trials
Supplementary Material for: Fluid control in neovascular age-related macular degeneration with brolucizumab: an analysis of the HAWK and HARRIER phase 3 trials Open
Introduction: Neovascular age-related macular degeneration (nAMD) is characterised by exudation of fluid from abnormally growing blood vessels in the macula. Anti-vascular endothelial growth factor (VEGF) therapy is standard treatment for …
View article: EFFECT OF RETINAL THICKNESS VARIABILITY ON VISUAL OUTCOMES AND FLUID PERSISTENCE IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
EFFECT OF RETINAL THICKNESS VARIABILITY ON VISUAL OUTCOMES AND FLUID PERSISTENCE IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION Open
Purpose: To determine the association between central subfield thickness (CST) variability and visual outcomes in eyes with neovascular age-related macular degeneration treated with anti–vascular endothelial growth factor therapies. Method…
View article: Intravitreal injections: past trends and future projections within a UK tertiary hospital
Intravitreal injections: past trends and future projections within a UK tertiary hospital Open
Aims To describe past trends and future projections for the number of intravitreal injections being administered at a large tertiary hospital in London, United Kingdom. Methods Retrospective data from Moorfields Eye Hospital were collected…
View article: Ranibizumab treatment patterns in prior ranibizumab-treated neovascular age-related macular degeneration patients: Real-world outcomes from the LUMINOUS study
Ranibizumab treatment patterns in prior ranibizumab-treated neovascular age-related macular degeneration patients: Real-world outcomes from the LUMINOUS study Open
Purpose To evaluate the effectiveness, safety, and treatment patterns of ranibizumab 0.5 mg in prior ranibizumab-treated patients with neovascular age-related macular degeneration (nAMD) enrolled in the LUMINOUS ™ study. Patients and metho…