Robin Kahn
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View article: Impaired cellular immune responses to Herpes Zoster subunit vaccine in patients with rheumatoid arthritis receiving Janus kinase inhibitors
Impaired cellular immune responses to Herpes Zoster subunit vaccine in patients with rheumatoid arthritis receiving Janus kinase inhibitors Open
Objective To investigate cellular immune responses to the herpes zoster (HZ) subunit (HZ/su) vaccine in patients with rheumatoid arthritis (RA) treated with Janus Kinase inhibitors (JAKi). Methods RA patients treated with JAKi (n = 46) at …
View article: Low ICU Admission and Excellent Outcomes in MIS‐C: A Swedish Study From an Open Society
Low ICU Admission and Excellent Outcomes in MIS‐C: A Swedish Study From an Open Society Open
Aim During the COVID‐19 pandemic, Sweden chose a more open public health approach. A general concern was that this approach would affect the population negatively. We describe the Swedish national MIS‐C cohort and risk factors for severe d…
View article: Data‐Driven Cluster Analysis of Cerebrospinal Fluid Proteome and Associations with Clinical Phenotypes in Systemic Lupus Erythematosus
Data‐Driven Cluster Analysis of Cerebrospinal Fluid Proteome and Associations with Clinical Phenotypes in Systemic Lupus Erythematosus Open
Objective To explore the cerebrospinal fluid (CSF) proteome in systemic lupus erythematosus (SLE) and the associations between the CSF proteomic patterns and clinical manifestations. Methods CSF samples from 29 female outpatients with SLE …
View article: Complement activation was not increased in patients with post-acute sequelae after mild SARS-CoV-2 infection: A prospective cohort study
Complement activation was not increased in patients with post-acute sequelae after mild SARS-CoV-2 infection: A prospective cohort study Open
Dysregulation of the complement system has been proposed as a pathophysiological mechanism for Post-acute sequelae of SARS-CoV-2 (PASC). We analyzed the complement activation markers C3bc, C3bBbP and TCC in 48 PASC patients, grouped into w…
View article: Modeling the t(2; 5) Translocation of Anaplastic Large Cell Lymphoma Using CRISPR-Mediated Chromosomal Engineering
Modeling the t(2; 5) Translocation of Anaplastic Large Cell Lymphoma Using CRISPR-Mediated Chromosomal Engineering Open
ALK+ Anaplastic Large Cell Lymphoma (ALCL) is an aggressive T-cell lymphoma that is characterized by expression of the Anaplastic Lymphoma Kinase (ALK), which is induced by the t(2;5) chromosomal rearrangement leading to the expression of …
View article: Engineered and decellularized human cartilage graft exhibits intrinsic immuno-evasive properties and full skeletal repair capacity
Engineered and decellularized human cartilage graft exhibits intrinsic immuno-evasive properties and full skeletal repair capacity Open
Tissue engineering strategies predominantly consist of the autologous generation of living substitutes capable of restoring damaged body parts. Persisting challenges with patient-specific approaches include inconsistent performance, high c…
View article: Synovial fibroblasts from children with oligoarticular juvenile idiopathic arthritis induce migration and prolong viability of neutrophils
Synovial fibroblasts from children with oligoarticular juvenile idiopathic arthritis induce migration and prolong viability of neutrophils Open
Introduction Little is known of the processes that trigger neutrophil activation in the joint of patients with oligoarticular juvenile idiopathic arthritis (oJIA), and if synovial fibroblasts (S-Fib) play an important role in the activatio…
View article: O18 Data-driven clustering of cerebrospinal fluid proteome reflects clinical phenotypes of systemic lupus erythematosus
O18 Data-driven clustering of cerebrospinal fluid proteome reflects clinical phenotypes of systemic lupus erythematosus Open
Objective Neuropsychiatric (NP) symptoms are frequent in patients with systemic lupus erythematosus (SLE) and signs of neuronal damage can be present in patients without evident NP involvement. The cerebrospinal fluid (CSF) protein pattern…
View article: Capillary leak syndrome was associated with more severe multisystem inflammatory syndrome in children during the <scp>COVID</scp>‐19 pandemic
Capillary leak syndrome was associated with more severe multisystem inflammatory syndrome in children during the <span>COVID</span>‐19 pandemic Open
Aim This population‐based study investigated the occurrence of capillary leak syndrome (CLS) in children with multisystem inflammatory syndrome in children (MIS‐C), associated with COVID‐19. We also examined associations between CLS and MI…
View article: Synovial monocytes contribute to chronic inflammation in childhood-onset arthritis via IL-6/STAT signalling and cell-cell interactions
Synovial monocytes contribute to chronic inflammation in childhood-onset arthritis via IL-6/STAT signalling and cell-cell interactions Open
Introduction Monocytes are key effector cells in inflammatory processes. We and others have previously shown that synovial monocytes in childhood-onset arthritis are activated. However, very little is known about how they contribute to dis…
View article: Synovial Monocytes Drive the Pathogenesis in Oligoarticular Juvenile Idiopathic Arthritis via IL-6/JAK/STAT Signalling and Cell-Cell Interactions
Synovial Monocytes Drive the Pathogenesis in Oligoarticular Juvenile Idiopathic Arthritis via IL-6/JAK/STAT Signalling and Cell-Cell Interactions Open
Objectives Synovial monocytes in oligoarticular juvenile idiopathic arthritis (oJIA) are polarized, but little is known of how they contribute to disease and attain their pathogenic features. The aim of this study was to investigate the ro…
View article: Identification of novel autoantigens as potential biomarkers in juvenile idiopathic arthritis associated uveitis
Identification of novel autoantigens as potential biomarkers in juvenile idiopathic arthritis associated uveitis Open
Background Many children with juvenile idiopathic arthritis (JIA) have autoantibodies, targeting nuclear components (anti-nuclear antibodies, ANA). ANA in JIA is associated with uveitis, an eye inflammation which may cause permanent vision…
View article: The risk of depression and anxiety is not increased in individuals with juvenile idiopathic arthritis – results from the south-Swedish juvenile idiopathic arthritis cohort
The risk of depression and anxiety is not increased in individuals with juvenile idiopathic arthritis – results from the south-Swedish juvenile idiopathic arthritis cohort Open
Background Children with chronic diseases are reported to have increased risk of psychiatric comorbidity. Few studies have investigated this risk in juvenile idiopathic arthritis (JIA), with conflicting results. We performed a population-b…
View article: The risk of depression and anxiety is not increased in individuals with juvenile idiopathic arthritis – results from the south-Swedish juvenile idiopathic arthritis cohort
The risk of depression and anxiety is not increased in individuals with juvenile idiopathic arthritis – results from the south-Swedish juvenile idiopathic arthritis cohort Open
Background Children with chronic diseases are reported to have increased risk of psychiatric comorbidity. Few studies have investigated this risk in juvenile idiopathic arthritis (JIA), with conflicting results. We performed a population-b…
View article: Enrichment of Complement, Immunoglobulins, and Autoantibody Targets in the Proteome of Platelets from Patients with Systemic Lupus Erythematosus
Enrichment of Complement, Immunoglobulins, and Autoantibody Targets in the Proteome of Platelets from Patients with Systemic Lupus Erythematosus Open
Background Systemic lupus erythematosus (SLE) is a complex disease characterized by autoimmunity toward apoptotic cells, excessive amounts of circulating immune complexes, and complement activation. A decreased platelet size has been obser…
View article: Ascorbic acid attenuates activation and cytokine production in sepsis-like monocytes
Ascorbic acid attenuates activation and cytokine production in sepsis-like monocytes Open
Sepsis manifests due to the host's dysregulated immune response to infection. High-dose ascorbic acid (AA) has emerged as a potential treatment of sepsis, yet little is known regarding how AA influences the immune system in sepsis, such as…
View article: Neutrophils Lose the Capacity to Suppress T Cell Proliferation Upon Migration Towards Inflamed Joints in Juvenile Idiopathic Arthritis
Neutrophils Lose the Capacity to Suppress T Cell Proliferation Upon Migration Towards Inflamed Joints in Juvenile Idiopathic Arthritis Open
Neutrophils are highly abundant in synovial fluid of rheumatic inflamed joints. In oligoarticular juvenile idiopathic arthritis (JIA), synovial fluid neutrophils have impaired effector functions and altered phenotype. We hypothesized that …
View article: Increasing Incidence of Juvenile Idiopathic Arthritis: A Trend Over 31 Years in Southern Sweden
Increasing Incidence of Juvenile Idiopathic Arthritis: A Trend Over 31 Years in Southern Sweden Open
Background The reported incidence of juvenile idiopathic arthritis (JIA) varies from studies around the world, depending on patient collection techniques, geographic region, and time. Our aim was to study the mean annual incidence of juven…
View article: Population‐based study of multisystem inflammatory syndrome associated with COVID‐19 found that 36% of children had persistent symptoms
Population‐based study of multisystem inflammatory syndrome associated with COVID‐19 found that 36% of children had persistent symptoms Open
Aim Our aim was to describe the outcomes of multisystem inflammatory syndrome in children (MIS‐C) associated with COVID‐19. Methods This national, population‐based, longitudinal, multicentre study used Swedish data that were prospectively …
View article: Low Intra-Individual Variation in Mean Platelet Volume Over Time in Systemic Lupus Erythematosus
Low Intra-Individual Variation in Mean Platelet Volume Over Time in Systemic Lupus Erythematosus Open
Platelets have recently emerged as important immune modulators in systemic lupus erythematosus (SLE), in addition to their role in thrombosis and cardiovascular disease. However, studies investigating mean platelet volume (MPV) in SLE are …
View article: Ascorbic acid attenuates activation and cytokine production in sepsis-like monocytes
Ascorbic acid attenuates activation and cytokine production in sepsis-like monocytes Open
Sepsis manifests due to the host’s dysregulated immune response to an infection. High dose ascorbic acid (AA) has emerged as a potential treatment of sepsis, yet little is known regarding how ascorbic acid influences the immune system in s…
View article: Synovial fluid neutrophils in oligoarticular juvenile idiopathic arthritis have an altered phenotype and impaired effector functions
Synovial fluid neutrophils in oligoarticular juvenile idiopathic arthritis have an altered phenotype and impaired effector functions Open
Background Neutrophils are the most prevalent immune cells in the synovial fluid in inflamed joints of children with oligoarticular juvenile idiopathic arthritis (JIA). Despite this, little is known about neutrophil function at the site of…
View article: Synovial Fluid Neutrophils in Oligoarticular Juvenile Idiopathic Arthritis Have an Altered Phenotype and Impaired Effector Functions
Synovial Fluid Neutrophils in Oligoarticular Juvenile Idiopathic Arthritis Have an Altered Phenotype and Impaired Effector Functions Open
BackgroundNeutrophils are the most prevalent immune cells in synovial fluid in inflamed joints of children with oligoarticular juvenile idiopathic arthritis (JIA). Despite this, little is known about neutrophil function at the site of infl…