Robin Kobbe
YOU?
Author Swipe
View article: Performance of whole blood interferon-γ release assays in SARS-CoV-2 and tuberculosis is age dependent
Performance of whole blood interferon-γ release assays in SARS-CoV-2 and tuberculosis is age dependent Open
Introduction A lot of research has been done, mainly on tuberculosis (TB), on the extent to which cellular immune protection as measured by interferon-γ release assays (IGRA) is age-dependent. In a previous study we showed that following a…
View article: A study protocol for neonatal sepsis and gut microbiomics among preterm infants admitted at Muhimbili National Hospital, Tanzania
A study protocol for neonatal sepsis and gut microbiomics among preterm infants admitted at Muhimbili National Hospital, Tanzania Open
Background Neonatal mortality remains high in many low- and middle-income countries (LMICs), with neonatal sepsis and antimicrobial resistance (AMR) posing significant threats to newborns, particularly in sub-Saharan Africa (SSA). Tanzania…
View article: Virological outcomes and genotypic resistance on dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial
Virological outcomes and genotypic resistance on dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial Open
Penta Foundation, ViiV Healthcare, and UK Medical Research Council.
View article: P-1934. Differences between the Reporting of Post-COVID-19 Symptoms and the Associated Health-Related Quality of Life during and after COVID-19 Infection - results of the Cross-Sectoral Platform of the German National Pandemic Cohort Network
P-1934. Differences between the Reporting of Post-COVID-19 Symptoms and the Associated Health-Related Quality of Life during and after COVID-19 Infection - results of the Cross-Sectoral Platform of the German National Pandemic Cohort Network Open
Background Post-COVID-19 syndrome (PCS) prevalences range from 10% up to 45%, caused by heterogeneous definitions, different study designs and survey methods, and sometimes misattribution of unrelated comorbidities to PCS. First correlatio…
View article: Vernachlässigte Tropenkrankheiten
Vernachlässigte Tropenkrankheiten Open
Zusammenfassung Vernachlässigte Tropenkrankheiten („neglected tropical diseases“, NTD) sind, insbesondere in ressourcenlimitierten Regionen und Ländern, ein bedeutendes globales Gesundheitsproblem. Klimawandel, politische Unruhen und wirts…
View article: Health and socio-demographic background of Ukrainian minors and their families in Germany - challenges for refugee medicine
Health and socio-demographic background of Ukrainian minors and their families in Germany - challenges for refugee medicine Open
In 2022, over 1,000,000 people from Ukraine fled to Germany, mostly women and children. The aim of this study was to determine health status and socio-demographic background of Ukrainian refugee minors in Germany and to compare that to Ger…
View article: Management and outcome of cutaneous diphtheria in adolescent refugees in Germany, June 2022 – October 2023
Management and outcome of cutaneous diphtheria in adolescent refugees in Germany, June 2022 – October 2023 Open
View article: Delayed Induction of Noninflammatory SARS-CoV-2 Spike-Specific IgG4 Antibodies Detected 1 Year After BNT162b2 Vaccination in Children
Delayed Induction of Noninflammatory SARS-CoV-2 Spike-Specific IgG4 Antibodies Detected 1 Year After BNT162b2 Vaccination in Children Open
Humoral immune responses after BNT162b2 vaccination are predominantly composed of immunoglobulin (Ig) G1 and IgG3 subclass antibodies. As previously described in adults, S1-specific and receptor-binding domain–specific IgG4 levels increase…
View article: Prevalence of infectious diseases, immunity to vaccine-preventable diseases and chronic medical conditions among Ukrainian refugees in Germany – A cross sectional study from the German Network University Medicine (NUM)
Prevalence of infectious diseases, immunity to vaccine-preventable diseases and chronic medical conditions among Ukrainian refugees in Germany – A cross sectional study from the German Network University Medicine (NUM) Open
We show evidence of low serological response to vaccine-preventable infections and increased LTBI prevalence in Ukrainian refugees. These findings should be integrated into guidelines for screening and treatment of infectious diseases in m…
View article: Partially reversible immunodeficiency after in-utero exposure to immunosuppressants
Partially reversible immunodeficiency after in-utero exposure to immunosuppressants Open
View article: Correction to: Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4‑Dependent Transendocytosis by Flow Cytometry
Correction to: Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4‑Dependent Transendocytosis by Flow Cytometry Open
View article: Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry
Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry Open
View article: Neuropsychiatric manifestations and sleep disturbances with dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial
Neuropsychiatric manifestations and sleep disturbances with dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial Open
View article: Reduced Humoral and Cellular Immune Response to Primary COVID-19 mRNA Vaccination in Kidney Transplanted Children Aged 5–11 Years
Reduced Humoral and Cellular Immune Response to Primary COVID-19 mRNA Vaccination in Kidney Transplanted Children Aged 5–11 Years Open
The situation of limited data concerning the response to COVID-19 mRNA vaccinations in immunocom-promised children hinders evidence-based recommendations. This prospective observational study investigated humoral and T cell responses after…
View article: Neuropsychiatric Manifestations and Sleep Disturbances in Children and Adolescents Randomised to Dolutegravir-Based Antiretroviral Therapy vs Standard-of-Care in the Odyssey Trial
Neuropsychiatric Manifestations and Sleep Disturbances in Children and Adolescents Randomised to Dolutegravir-Based Antiretroviral Therapy vs Standard-of-Care in the Odyssey Trial Open
View article: Treatment of Infants and Children With SARS-CoV-2 Monoclonal Antibodies: A European Case Series
Treatment of Infants and Children With SARS-CoV-2 Monoclonal Antibodies: A European Case Series Open
Background: Although severe COVID-19 in children is rare, those with certain pre-existing health conditions are more prone to severe disease. Monoclonal antibodies (mAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…
View article: Infektiologische Versorgung minderjähriger Flüchtlinge am Beispiel der Ukraine
Infektiologische Versorgung minderjähriger Flüchtlinge am Beispiel der Ukraine Open
View article: Long-Term Antibody Response to SARS-CoV-2 in Children
Long-Term Antibody Response to SARS-CoV-2 in Children Open
Almost 2 years into the pandemic and with vaccination of children significantly lagging behind adults, long-term pediatric humoral immune responses to SARS-CoV-2 are understudied. The C19.CHILD Hamburg (COVID-19 Child Health Investigation …
View article: Detrimental NFKB1 missense variants affecting the Rel-homology domain of p105/p50
Detrimental NFKB1 missense variants affecting the Rel-homology domain of p105/p50 Open
Most of the currently known heterozygous pathogenic NFKB1 (Nuclear factor kappa B subunit 1) variants comprise deleterious defects such as severe truncations, internal deletions, and frameshift variants. Collectively, these represent the m…
View article: Clinical efficacy and in vitro neutralization capacity of monoclonal antibodies for severe acute respiratory syndrome coronavirus 2 delta and omicron variants
Clinical efficacy and in vitro neutralization capacity of monoclonal antibodies for severe acute respiratory syndrome coronavirus 2 delta and omicron variants Open
We aimed to provide in vitro data on the neutralization capacity of different monoclonal antibody (mAb) preparations against the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) delta and omicron variant, respectively, and desc…
View article: Aktualisierte Empfehlungen zur infektiologischen Versorgung von Flüchtlingen im Kindes- und Jugendalter in Deutschland (Stand 30. März 2022), angemeldet als S1-Leitlinie (AWMF-Register Nr. 048-017)
Aktualisierte Empfehlungen zur infektiologischen Versorgung von Flüchtlingen im Kindes- und Jugendalter in Deutschland (Stand 30. März 2022), angemeldet als S1-Leitlinie (AWMF-Register Nr. 048-017) Open
View article: Einheitliche Basisversorgung von Kindern und Jugendlichen mit Long COVID
Einheitliche Basisversorgung von Kindern und Jugendlichen mit Long COVID Open
View article: A single center study investigating the olfactory dysfunction of hospitalized patients with PCR-confirmed, active COVID-19 disease
A single center study investigating the olfactory dysfunction of hospitalized patients with PCR-confirmed, active COVID-19 disease Open
Background A loss of smell is often the first symptom of a COVID-19 infection. This study examined olfactory dysfunction (OD) of hospitalized COVID-19 patients in a single centre in a cross-sectional and longitudinal fashion.
View article: Monozentrische Untersuchung der Riechstörung bei hospitalisierten Patienten mit PCR-bestätigter, aktiver COVID-19-Infektion
Monozentrische Untersuchung der Riechstörung bei hospitalisierten Patienten mit PCR-bestätigter, aktiver COVID-19-Infektion Open
Hintergrund Der Verlust des Geruchsinns ist häufig das erste Symptom einer COVID-19-Infektion. In dieser Studie wurde die olfaktorische Dysfunktion (OD) bei hospitalisierten COVID-19-Patienten in einem Zentrum im Quer- und Längsschnitt unt…
View article: Correction to: A Multi-center, Open-Label, Single-Arm Trial to Evaluate the Efficacy, Pharmacokinetics, and Safety and Tolerability of IGSC 20% in Subjects with Primary Immunodeficiency
Correction to: A Multi-center, Open-Label, Single-Arm Trial to Evaluate the Efficacy, Pharmacokinetics, and Safety and Tolerability of IGSC 20% in Subjects with Primary Immunodeficiency Open
View article: Long-term antibody response to SARS-CoV-2 in children
Long-term antibody response to SARS-CoV-2 in children Open
Almost two years into the pandemic and with vaccination of children significantly lagging behind adults, long-term pediatric humoral immune responses to SARS-CoV-2 are understudied. The C19.CHILD Hamburg (COVID-19 Child Health Investigatio…
View article: Data quality of reported child immunization coverage in 194 countries between 2000 and 2019
Data quality of reported child immunization coverage in 194 countries between 2000 and 2019 Open
Analyzing immunization coverage data is crucial to guide decision-making in national immunization programs and monitor global initiatives such as the Immunization Agenda 2030. We aimed to assess the quality of reported child immunization c…
View article: A Multi‑Center, Open‑Label, Single‑Arm Trial to Evaluate the Efficacy, Pharmacokinetics, and Safety and Tolerability of IGSC 20% in Subjects with Primary Immunodeficiency
A Multi‑Center, Open‑Label, Single‑Arm Trial to Evaluate the Efficacy, Pharmacokinetics, and Safety and Tolerability of IGSC 20% in Subjects with Primary Immunodeficiency Open
View article: Establishing the Molecular Diagnoses in a Cohort of 291 Patients With Predominantly Antibody Deficiency by Targeted Next-Generation Sequencing: Experience From a Monocentric Study
Establishing the Molecular Diagnoses in a Cohort of 291 Patients With Predominantly Antibody Deficiency by Targeted Next-Generation Sequencing: Experience From a Monocentric Study Open
Predominantly antibody deficiencies (PAD) are a heterogeneous group of disorders characterized by dysfunctional antibody production, low immunoglobulin levels in serum and impaired vaccine responses. The clinical picture is variable, rangi…
View article: Fatal outcome of SARS-CoV-2 infection (B1.1.7) in a 4-year-old child
Fatal outcome of SARS-CoV-2 infection (B1.1.7) in a 4-year-old child Open
This case report highlights details of a case of critical acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) with B1.1.7 variant in a 4-year-old girl who died due to pneumonia and pulmonary hemorrhage. The girl was referred to our …