Robin L. Haynes
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View article: Automated <scp>MRI</scp> Segmentation of Brainstem Nuclei Critical to Consciousness
Automated <span>MRI</span> Segmentation of Brainstem Nuclei Critical to Consciousness Open
Although substantial progress has been made in mapping the connectivity of cortical networks responsible for conscious awareness, neuroimaging analysis of subcortical networks that modulate arousal (i.e., wakefulness) has been limited by a…
View article: Serotonergic receptor binding in the brainstem in the Sudden Infant Death Syndrome in a high-risk population
Serotonergic receptor binding in the brainstem in the Sudden Infant Death Syndrome in a high-risk population Open
The Sudden Infant Death Syndrome (SIDS) is a major global health problem, with increased risk among socioeconomically disadvantaged populations. We propose SIDS, or a subset, is due to a defect in the brainstem serotonin system mediating c…
View article: The Use of Synaptic Extracellular Myo‐Inositol to Treat Developmental and Epileptic Encephalopathy
The Use of Synaptic Extracellular Myo‐Inositol to Treat Developmental and Epileptic Encephalopathy Open
Objective The developmental and epileptic encephalopathies (DEE) are associated with serious and lifelong neurological conditions and risk of early mortality. Here, we describe the chronic treatment of a boy with PLCB1 ‐related DEE with en…
View article: Temporal and cell-type specific SPAK-NKCC1 disruption following severe TBI in the developing gyrencephalic brain
Temporal and cell-type specific SPAK-NKCC1 disruption following severe TBI in the developing gyrencephalic brain Open
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in infants and toddlers, with limited treatment options and persistent neurological sequelae. We developed a multi-pathoanatomic lesion multi-insult (MuLMI) severe …
View article: Histology-guided MRI segmentation of brainstem nuclei critical to consciousness
Histology-guided MRI segmentation of brainstem nuclei critical to consciousness Open
While substantial progress has been made in mapping the connectivity of cortical networks responsible for conscious awareness, neuroimaging analysis of subcortical arousal networks that modulate arousal (i.e., wakefulness) has been limited…
View article: Integration of imaging measurements at micro-, meso and macro-scale of the caudal medulla on a postmortem infant subject
Integration of imaging measurements at micro-, meso and macro-scale of the caudal medulla on a postmortem infant subject Open
The core lesion of SIDS is a set of medullar nuclei with abnormalities correlated with sudden infant death syndrome (SIDS). We performed ex vivo whole brain and brainstem MRI, optical coherence tomography and histology at an unprecedented …
View article: Platelet Pathophysiology: Unexpected New Research Directions
Platelet Pathophysiology: Unexpected New Research Directions Open
We are very honored that our 2016 review of platelet physiology[1] is one of the top three most downloaded papers in Seminars and Thrombosis and Haemostasis from 2014 to 2023. But why study platelet physiology? Because these remarkable lit…
View article: Dysregulation of platelet serotonin, 14–3–3, and GPIX in sudden infant death syndrome
Dysregulation of platelet serotonin, 14–3–3, and GPIX in sudden infant death syndrome Open
Sudden infant death syndrome (SIDS) is the leading cause of post-neonatal infant mortality, but the underlying cause(s) are unclear. A subset of SIDS infants has abnormalities in the neurotransmitter, serotonin (5-hydroxytryptamine [5-HT])…
View article: Multimodal MRI reveals brainstem connections that sustain wakefulness in human consciousness
Multimodal MRI reveals brainstem connections that sustain wakefulness in human consciousness Open
Consciousness is composed of arousal (i.e., wakefulness) and awareness. Substantial progress has been made in mapping the cortical networks that underlie awareness in the human brain, but knowledge about the subcortical networks that susta…
View article: Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part II. Age-associated alterations in serotonin receptor binding profiles within medullary nuclei supporting cardiorespiratory homeostasis
Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part II. Age-associated alterations in serotonin receptor binding profiles within medullary nuclei supporting cardiorespiratory homeostasis Open
The failure of chemoreflexes, arousal, and/or autoresuscitation to asphyxia may underlie some sudden infant death syndrome (SIDS) cases. In Part I, we showed that some SIDS infants had altered 5-hydroxytryptamine (5-HT)2A/C receptor bindin…
View article: Multiomic Analysis of Neuroinflammation and Occult Infection in Sudden Infant Death Syndrome
Multiomic Analysis of Neuroinflammation and Occult Infection in Sudden Infant Death Syndrome Open
Importance Antemortem infection is a risk factor for sudden infant death syndrome (SIDS)—the leading postneonatal cause of infant mortality in the developed world. Manifestations of infection and inflammation are not always apparent in cli…
View article: Sustaining wakefulness: Brainstem connectivity in human consciousness
Sustaining wakefulness: Brainstem connectivity in human consciousness Open
Consciousness is comprised of arousal (i.e., wakefulness) and awareness. Substantial progress has been made in mapping the cortical networks that modulate awareness in the human brain, but knowledge about the subcortical networks that sust…
View article: Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part I. Tissue-based evidence for serotonin receptor signaling abnormalities in cardiorespiratory- and arousal-related circuits
Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part I. Tissue-based evidence for serotonin receptor signaling abnormalities in cardiorespiratory- and arousal-related circuits Open
The sudden infant death syndrome (SIDS), the leading cause of postneonatal infant mortality in the United States, is typically associated with a sleep period. Previously, we showed evidence of serotonergic abnormalities in the medulla (e.g…
View article: Copy Number Variation and Structural Genomic Findings in 116 Cases of Sudden Unexplained Death between 1 and 28 Months of Age
Copy Number Variation and Structural Genomic Findings in 116 Cases of Sudden Unexplained Death between 1 and 28 Months of Age Open
In sudden unexplained death in pediatrics (SUDP) the cause of death is unknown despite an autopsy and investigation. The role of copy number variations (CNVs) in SUDP has not been well‐studied. Chromosomal microarray (CMA) data are generat…
View article: Genetic Determinants of Sudden Unexpected Death in Pediatrics
Genetic Determinants of Sudden Unexpected Death in Pediatrics Open
View article: Medullary Serotonergic Binding Deficits and Hippocampal Abnormalities in Sudden Infant Death Syndrome: One or Two Entities?
Medullary Serotonergic Binding Deficits and Hippocampal Abnormalities in Sudden Infant Death Syndrome: One or Two Entities? Open
Sudden infant death syndrome (SIDS) is understood as a syndrome that presents with the common phenotype of sudden death but involves heterogenous biological causes. Many pathological findings have been consistently reported in SIDS, notabl…
View article: Association of Prenatal Exposure to Maternal Drinking and Smoking With the Risk of Stillbirth
Association of Prenatal Exposure to Maternal Drinking and Smoking With the Risk of Stillbirth Open
These results suggest that combined drinking and smoking after the first trimester of pregnancy, compared with no exposure or quitting before the end of the first trimester, may be associated with a significantly increased risk of late sti…
View article: Airway basal stem cells generate distinct subpopulations of PNECs
Airway basal stem cells generate distinct subpopulations of PNECs Open
View article: Nicotinic Receptors in the Brainstem Ascending Arousal System in SIDS With Analysis of Pre-natal Exposures to Maternal Smoking and Alcohol in High-Risk Populations of the Safe Passage Study
Nicotinic Receptors in the Brainstem Ascending Arousal System in SIDS With Analysis of Pre-natal Exposures to Maternal Smoking and Alcohol in High-Risk Populations of the Safe Passage Study Open
Pre-natal exposures to nicotine and alcohol are known risk factors for sudden infant death syndrome (SIDS), the leading cause of post-neonatal infant mortality. Here, we present data on nicotinic receptor binding, as determined by 125 I-ep…
View article: Genetic Determinants of Sudden Unexpected Death in Pediatrics
Genetic Determinants of Sudden Unexpected Death in Pediatrics Open
View article: Discriminatory cytokine profiles predict muscle function, fatigue and cognitive function in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Discriminatory cytokine profiles predict muscle function, fatigue and cognitive function in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Open
Myalgic Encephalomyelitis (ME) /Chronic Fatigue Syndrome (CFS) is a severely debilitating and complex illness of uncertain aetiology, affecting the lives of millions and characterised by prolonged fatigue. The initiating factors and mechan…
View article: The role of sodium channels in sudden unexpected death in pediatrics
The role of sodium channels in sudden unexpected death in pediatrics Open
Background Sudden Unexpected Death in Pediatrics (SUDP) is a tragic event, likely caused by the complex interaction of multiple factors. The presence of hippocampal abnormalities in many children with SUDP suggests that epilepsy‐related me…
View article: Concurrent prenatal drinking and smoking increases risk for SIDS: Safe Passage Study report
Concurrent prenatal drinking and smoking increases risk for SIDS: Safe Passage Study report Open
View article: Prenatal intermittent hypoxia sensitizes the laryngeal chemoreflex, blocks serotoninergic shortening of the reflex, and reduces 5-HT3 receptor binding in the NTS in anesthetized rat pups
Prenatal intermittent hypoxia sensitizes the laryngeal chemoreflex, blocks serotoninergic shortening of the reflex, and reduces 5-HT3 receptor binding in the NTS in anesthetized rat pups Open
View article: The Serotonin Brainstem Hypothesis for the Sudden Infant Death Syndrome
The Serotonin Brainstem Hypothesis for the Sudden Infant Death Syndrome Open
The sudden infant death syndrome (SIDS) is the leading cause of postneonatal infant mortality in the United States today, with an overall rate of 0.39/1000 live births. It is defined as the sudden and unexpected death of an infant <12 m…
View article: Mutations in <i>NRXN1</i> and <i>NRXN2</i> in a patient with early-onset epileptic encephalopathy and respiratory depression
Mutations in <i>NRXN1</i> and <i>NRXN2</i> in a patient with early-onset epileptic encephalopathy and respiratory depression Open
Early infantile epileptic encephalopathy (EIEE) is a severe disorder associated with epilepsy, developmental delay and intellectual disability, and in some cases premature mortality. We report the case of a female infant with EIEE and stri…
View article: <i>SCN1A</i> variants associated with sudden infant death syndrome
<i>SCN1A</i> variants associated with sudden infant death syndrome Open
Summary We identified SCN1A variants in 2 infants who died of sudden infant death syndrome (SIDS) with hippocampal abnormalities from an exome sequencing study of 10 cases of SIDS but no history of seizures. One harbored SCN 1A G682V, and …
View article: High serum serotonin in sudden infant death syndrome
High serum serotonin in sudden infant death syndrome Open
Significance Sudden infant death syndrome (SIDS), the leading cause of postneonatal infant mortality, is defined as the sudden death of an infant less than 1 y of age that remains unexplained after a complete autopsy and death scene invest…
View article: Drinking and smoking patterns during pregnancy: Development of group-based trajectories in the Safe Passage Study
Drinking and smoking patterns during pregnancy: Development of group-based trajectories in the Safe Passage Study Open
View article: The Lateral Temporal Lobe in Early Human Life
The Lateral Temporal Lobe in Early Human Life Open
Abnormalities of lateral temporal lobe development are associated with a spectrum of genetic and environmental pathologic processes, but more normative data are needed for a better understanding of gyrification in this brain region. Here, …