Robin M. Shaw
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View article: AAV9-cBIN1 gene therapy rescues chronic heart failure due to ischemic cardiomyopathy in a canine model
AAV9-cBIN1 gene therapy rescues chronic heart failure due to ischemic cardiomyopathy in a canine model Open
Chronic HF from ischemic cardiomyopathy can be successfully treated with low dose AAV9-cBIN1 gene therapy. This study indicates that myocardial specific therapy can dramatically reverse HF progression.
View article: Peroxisome proliferator-activated receptor gamma (<i>PPARG</i>)-mediated myocardial salvage in acute myocardial infarction managed with left ventricular unloading and coronary reperfusion
Peroxisome proliferator-activated receptor gamma (<i>PPARG</i>)-mediated myocardial salvage in acute myocardial infarction managed with left ventricular unloading and coronary reperfusion Open
Ischemic heart disease and acute myocardial infarction (AMI) is a leading cause of morbidity and mortality. Improvements have been made in coronary interventions to restore blood flow, but ischemia/reperfusion (I/R) injury significantly im…
View article: A truncated isoform of Connexin43 caps actin to organize forward delivery of full-length Connexin43
A truncated isoform of Connexin43 caps actin to organize forward delivery of full-length Connexin43 Open
While membrane proteins such as ion channels continuously turn over and require replacement, the mechanisms of specificity of efficient channel delivery to appropriate membrane subdomains remain poorly understood. GJA1-20k is a truncated C…
View article: Exploring the Potent Roles of an Internally Translated Truncated Connexin-43 Isoform
Exploring the Potent Roles of an Internally Translated Truncated Connexin-43 Isoform Open
Connexins are a family of transmembrane proteins that form membrane channels [...]
View article: Cardiac bridging integrator 1 gene therapy rescues chronic non-ischemic heart failure in minipigs
Cardiac bridging integrator 1 gene therapy rescues chronic non-ischemic heart failure in minipigs Open
Heart failure (HF) is a major cause of mortality and morbidity worldwide, yet with limited therapeutic options. Cardiac bridging integrator 1 (cBIN1), a cardiomyocyte transverse-tubule (t-tubule) scaffolding protein which organizes the cal…
View article: Cardiac gene therapy treats diabetic cardiomyopathy and lowers blood glucose
Cardiac gene therapy treats diabetic cardiomyopathy and lowers blood glucose Open
Diabetic cardiomyopathy, an increasingly global epidemic and a major cause of heart failure with preserved ejection fraction (HFpEF), is associated with hyperglycemia, insulin resistance, and intracardiomyocyte calcium mishandling. Here we…
View article: Echocardiography Recording in Awake Miniature Pigs
Echocardiography Recording in Awake Miniature Pigs Open
Echocardiography uses ultrasonic waves to non-invasively assess cardiac structure and function and is the standard of care for cardiac assessment and monitoring. The miniature pig, or minipig, is increasingly being used as a model of cardi…
View article: Table S4 from Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma
Table S4 from Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma Open
Spreadsheet of genes co-regulated by MYC & Miz1 in KMC PDAC cells
View article: Data from Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma
Data from Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma Open
MYC is implicated in the development and progression of pancreatic cancer, yet the precise level of MYC deregulation required to contribute to tumor development has been difficult to define. We used modestly elevated expression of human MY…
View article: Supplementary Material from Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma
Supplementary Material from Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma Open
6 supplementary Figures with legends under each; 3 Supplementary Tables; Supplementary Methods and References
View article: Supplementary Material from Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma
Supplementary Material from Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma Open
6 supplementary Figures with legends under each; 3 Supplementary Tables; Supplementary Methods and References
View article: Data from Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma
Data from Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma Open
MYC is implicated in the development and progression of pancreatic cancer, yet the precise level of MYC deregulation required to contribute to tumor development has been difficult to define. We used modestly elevated expression of human MY…
View article: Table S4 from Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma
Table S4 from Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma Open
Spreadsheet of genes co-regulated by MYC & Miz1 in KMC PDAC cells
View article: A canine model of chronic ischemic heart failure
A canine model of chronic ischemic heart failure Open
The novel total left anterior descending devascularization (TLD) approach in a canine ischemic heart failure model limits collateral flow in the ischemic zone and provides excellent early survival and repeatable development of chronic isch…
View article: Internal translation of Gja1 (Connexin43) to produce GJA1-20k: Implications for arrhythmia and ischemic-preconditioning
Internal translation of Gja1 (Connexin43) to produce GJA1-20k: Implications for arrhythmia and ischemic-preconditioning Open
Internal translation is a form of post-translation modification as it produces different proteins from one mRNA molecule by beginning translation at a methionine coding triplet downstream of the first methionine. Internal translation can e…
View article: Plasma brain injury markers are associated with volume status but not muscle health in heart failure patients
Plasma brain injury markers are associated with volume status but not muscle health in heart failure patients Open
Background: Neurofilament light chain protein (NfL) and tau are plasma biomarkers of neuronal injury which can be elevated in patients with neurodegenerative diseases. N-terminal pro-brain natriuretic peptide (NT-proBNP) is an established …
View article: A Canine Model of Chronic Ischemic Heart Failure
A Canine Model of Chronic Ischemic Heart Failure Open
Background There is a paucity of novel therapeutics for chronic heart failure (HF). Preclinical large animal models of chronic HF are crucial to translating fundamental discoveries. Canine models of ischemic cardiomyopathy are frequently u…
View article: GJA1-20k and Mitochondrial Dynamics
GJA1-20k and Mitochondrial Dynamics Open
Connexin 43 (Cx43) is the primary gap junction protein of mammalian heart ventricles and is encoded by the gene Gja1 which has a single coding exon and therefore cannot be spliced. We previously identified that Gja1 mRNA undergoes endogeno…
View article: GJA1-20k, an internally translated isoform of Connexin 43, is an actin capping protein
GJA1-20k, an internally translated isoform of Connexin 43, is an actin capping protein Open
Previously, we identified that GJA1-20k, an internally translated isoform of Connexin 43, mediates an actin-dependent protective form of mitochondrial fission (Shimura, Nuebel et al. 2021). We found that when GJA1-20k is present, bands of …
View article: Protective mitochondrial fission induced by stress-responsive protein GJA1-20k
Protective mitochondrial fission induced by stress-responsive protein GJA1-20k Open
The Connexin43 gap junction gene GJA1 has one coding exon, but its mRNA undergoes internal translation to generate N-terminal truncated isoforms of Connexin43 with the predominant isoform being only 20 kDa in size (GJA1-20k). Endogenous GJ…
View article: Baseline QRS Duration Associates with Cardiac Recovery in Patients with Continuous-Flow Left Ventricular Assist Device Implantation
Baseline QRS Duration Associates with Cardiac Recovery in Patients with Continuous-Flow Left Ventricular Assist Device Implantation Open
BACKGROUND In chronic heart failure (HF) patients supported with continuous-flow left ventricular assist device (CF-LVAD), we aimed to assess the clinical association of baseline QRS duration (QRSd) with post-LVAD cardiac recovery, and its…
View article: Association of coronary microvascular dysfunction and cardiac bridge integrator 1, a cardiomyocyte dysfunction biomarker
Association of coronary microvascular dysfunction and cardiac bridge integrator 1, a cardiomyocyte dysfunction biomarker Open
Background Coronary microvascular dysfunction (CMD) is associated with heart failure with preserved ejection fraction (HFpEF); however, pathophysiology is not well described. Hypothesis We hypothesized that CMD in women with suspected isch…